- Recommended
Florida Keys History and Discovery Center
History museum with exhibits on local pioneers, diving, fishing, rail and highway development, and life in the Upper Keys.
The best way to find a cheap bus ticket from Tampa, FL to Key Largo, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Tampa, FL to Key Largo, FL will cost around €50 if you buy it on the day, but the cheapest tickets can be found for only €50.
On Wed, Nov 04, we found 1 buses from Tampa, FL to Key Largo, FL, including 1 direct services.
On Wed, Nov 04 the direct buses cover the 376 km distance in an average of 13 h 5 m but if you time it right, some buses will get you there in just 13 h 5 m .
On Wed, Nov 04 the slowest buses will take 13 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Tampa, FL to Key Largo, FL run on average 4 times per day, taking around 8h 44m. Cheap bus tickets for this journey start at €37 but you can travel from only €26 by flight.
The earliest bus runs at 12:40, the last at 20:00. The fastest bus covers the 233 miles (376 km) distance in 7h 55m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Tampa, FL to Key Largo, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 09:25PM | Arrival Time 10:30AM | Duration 13h05 | Departure days Wed | Cheapest price €50 |
Operator Greyhound | Departure Time 09:55PM | Arrival Time 10:30AM | Duration 12h35 | Departure days Fri, Sun | Cheapest price €101 |
Buses from Tampa, FL to Key Largo, FL with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Key Largo, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Key Largo, FL trip today.
History museum with exhibits on local pioneers, diving, fishing, rail and highway development, and life in the Upper Keys.
Marine mammal facility with educational presentations and interactive programs focused on dolphin care, training, and conservation.
Working coral restoration center offering guided educational visits about reef science, nursery work, and ocean conservation.
Scenic road spine of Key Largo, lined with marinas, parks, shops, and classic island views along the Overseas Highway.
Popular state park known for mangroves, kayaking, birding, and one of the best short nature escapes in Key Largo.
Waterfront county park with beach access, kayak launch, picnic areas, and open views across Largo Sound.
Florida Keys pink shrimp, often simply grilled or sautéed. It is a regional staple prized for its sweet flavor and ties to local waters and seafood traditions.
Fresh local fish marinated in citrus with onion and peppers. A classic Florida Keys starter shaped by Caribbean and Latin seafood influences.
A rich chowder of conch, tomatoes, vegetables, and spices. It is a long-standing Keys favorite reflecting Bahamian and island culinary heritage.
Casual seafood spot known for local fish, conch dishes, and waterfront Keys atmosphere. Popular for laid-back meals after time on the water.
Upscale waterfront restaurant serving fresh seafood, steaks, and tropical drinks. Known for sunset views and a polished but relaxed setting.
Long-running local favorite for seafood baskets, sandwiches, and Key lime pie. Casual dockside feel with strong focus on fresh regional catch.
Key Largo is pricier than many Florida beach towns, with higher hotel, seafood dining, and car-dependent travel costs, especially in peak season.
Tip 15-20% at restaurants, $1-2 per drink at bars, and round up or tip 10-15% for taxis. Small tips are appreciated at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Key Largo, FL.
Find answers to the most common questions about traveling from Tampa, FL to Key Largo, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key Largo, FL, this guide helps you travel smarter and with confidence.

Most Tampa, FL to Key Largo, FL buses use the Tampa, Marion Transit Center to Key Largo, Overseas Hwy (Burger King) station pair. Use this guide to compare Tampa, FL and Key Largo, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Tampa, Marion Transit Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, Marion Transit Center. ATMs are available at Tampa, Marion Transit Center.
Ticket office support is available at Tampa, Marion Transit Center.
Available at Tampa, Marion Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at Tampa, Marion Transit Center: Wheelchair accessible with ramps.
Tampa, USF Holly Drive (Central Plant) is 13 km from Tampa city centre. Public transport options include:
Tampa, USF Holly Drive (Central Plant) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, USF Holly Drive (Central Plant). ATMs are available at Tampa, USF Holly Drive (Central Plant).
Ticket office support is available at Tampa, USF Holly Drive (Central Plant).
Available at Tampa, USF Holly Drive (Central Plant): Parking, Taxis, WC.
Accessibility facilities are available at Tampa, USF Holly Drive (Central Plant): Wheelchair accessible facilities.
Key Largo, Overseas Hwy (Burger King) is 1 km from Key Largo city centre. Public transport options include:
Key Largo, Overseas Hwy (Burger King) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Located near Burger King.
Wi-Fi is available at Key Largo, Overseas Hwy (Burger King). ATMs are available at Key Largo, Overseas Hwy (Burger King).
Ticket office support is available at Key Largo, Overseas Hwy (Burger King).
Available at Key Largo, Overseas Hwy (Burger King): Parking, Taxis, WC.
Accessibility facilities are available at Key Largo, Overseas Hwy (Burger King): Basic accessibility available.
Check bus stations information for Tampa, FL and Key Largo, FL, including where buses depart and arrive on this route.