- Recommended
Florida Keys History and Discovery Center
History museum with exhibits on local pioneers, diving, fishing, rail and highway development, and life in the Upper Keys.
The best way to find a cheap bus ticket from Orlando, FL to Key Largo, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Key Largo, FL will cost around $62 if you buy it on the day, but the cheapest tickets can be found for only $62.
It's difficult to get from Orlando, FL to Key Largo, FL without transferring at least 2 times.

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Buses from Orlando, FL to Key Largo, FL run on average 5 times per day, taking around 6h 24m. Cheap bus tickets for this journey start at $32 if you book in advance.
The earliest bus runs at 12:40, the last at 19:40. The fastest bus covers the 245 miles (395 km) distance in 5h 35m.
Distance 245 miles (395 km) |
Average bus duration 6h 24m |
Cheapest ticket price $32 |
Buses per day 5 |
Fastest bus 5h 35m |
First bus 12:40 PM |
Last bus 7:40 PM |
Cheapest Month Sep |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Oct - Dec |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Orlando, FL to Key Largo, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 03:05AM | Arrival Time 10:30AM | Duration 7h25 | Departure days Sat | Cheapest price $71 |
Operator FlixBus | Departure Time 05:15AM | Arrival Time 04:30PM | Duration 11h15 | Departure days Thu | Cheapest price $86 |
Operator Jet Set Express | Departure Time 07:00AM | Arrival Time 06:30AM | Duration 23h30 | Departure days Tue, Wed | Cheapest price $62 |
The table below shows live departures for Orlando, FL to Key Largo, FL buses for today, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:00 AM Orlando, FL | 23h30 | 6:30 AM Key Largo, FL | 2 transfers | |
This is the last bus of the day. | |||||
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Discover the best of Key Largo, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Key Largo, FL trip today.
History museum with exhibits on local pioneers, diving, fishing, rail and highway development, and life in the Upper Keys.
Marine mammal facility with educational presentations and interactive programs focused on dolphin care, training, and conservation.
Working coral restoration center offering guided educational visits about reef science, nursery work, and ocean conservation.
Scenic road spine of Key Largo, lined with marinas, parks, shops, and classic island views along the Overseas Highway.
Popular state park known for mangroves, kayaking, birding, and one of the best short nature escapes in Key Largo.
Waterfront county park with beach access, kayak launch, picnic areas, and open views across Largo Sound.
Florida Keys pink shrimp, often simply grilled or sautéed. It is a regional staple prized for its sweet flavor and ties to local waters and seafood traditions.
Fresh local fish marinated in citrus with onion and peppers. A classic Florida Keys starter shaped by Caribbean and Latin seafood influences.
A rich chowder of conch, tomatoes, vegetables, and spices. It is a long-standing Keys favorite reflecting Bahamian and island culinary heritage.
Casual seafood spot known for local fish, conch dishes, and waterfront Keys atmosphere. Popular for laid-back meals after time on the water.
Upscale waterfront restaurant serving fresh seafood, steaks, and tropical drinks. Known for sunset views and a polished but relaxed setting.
Long-running local favorite for seafood baskets, sandwiches, and Key lime pie. Casual dockside feel with strong focus on fresh regional catch.
Key Largo is pricier than many Florida beach towns, with higher hotel, seafood dining, and car-dependent travel costs, especially in peak season.
Tip 15-20% at restaurants, $1-2 per drink at bars, and round up or tip 10-15% for taxis. Small tips are appreciated at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Key Largo, FL.
Find answers to the most common questions about traveling from Orlando, FL to Key Largo, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key Largo, FL, this guide helps you travel smarter and with confidence.

Most Orlando, FL to Key Largo, FL buses use the Orlando, N John Young Pkwy (Greyhound Bus Station) to Key Largo, Overseas Hwy (Burger King) station pair. Use this guide to compare Orlando, FL and Key Largo, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
Key Largo, Overseas Hwy (Burger King) is 1 km from Key Largo city centre. Public transport options include:
Key Largo, Overseas Hwy (Burger King) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Located near Burger King.
Wi-Fi is available at Key Largo, Overseas Hwy (Burger King). ATMs are available at Key Largo, Overseas Hwy (Burger King).
Ticket office support is available at Key Largo, Overseas Hwy (Burger King).
Available at Key Largo, Overseas Hwy (Burger King): Parking, Taxis, WC.
Accessibility facilities are available at Key Largo, Overseas Hwy (Burger King): Basic accessibility available.
Check bus stations information for Orlando, FL and Key Largo, FL, including where buses depart and arrive on this route.
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