San Diego to Irvine, CA bus

Amtrak is the main bus company in the United States and operates medium and long-distance intercity services in 46 American states and 3 Canadian provinces. With over 300 Amtrak buses running daily, you can travel by bus across America and explore destinations near and far. Take the Acela bus for high-speed services connecting popular cities in the Northeast, the Coast Starlight to travel up and down the stunning West Coast or the Empire Builder to travel from Chicago to the Midwest and the Pacific Northwest among others. Amtrak offers different class options to suit any traveler’s budget with classes like Coach, Business, First and the Sleeper Class, where you can book a Roomette, Bedroom, and Bedroom suite among others for night travel. When you book your bus journey from San Diego to Irvine, CA, you can choose between ticket types like Saver, Value, Flexible, Business and Premium.

Enjoy a smooth and easy trip between San Diego and Irvine, CA with Greyhound! As an official travel partner of Greyhound, Omio can help you search current bus schedules and timetables from Greyhound, compare the best routes to Irvine, CA from San Diego as well as the class fares available for this route (including information on baggage allowance and amenities provided onboard), and buy the most affordable Greyhound San Diego to Irvine, CA bus ticket available today. If you search for Greyhound tickets in the Omio app, you can also see if they are mobile tickets so that you can travel paperless rather than needing to wait in a line at the bus station in person to purchase tickets. Once you find your ideal route, book your one-way bus from San Diego to Irvine, CA on Omio or in the Omio app in just a few simple steps. You can then sit back and enjoy the 76 miles (122 km) route to Irvine, CA from San Diego with ease and comfort on a bus with Greyhound.