- Must visit
Uffizi Galleries
Florence’s premier art museum, famed for Renaissance masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. One of Italy’s essential museum visits.
Omio recommends booking the train as it is the most popular option from Mendrisio to Florence among Omio's users. If you are prioritising price take the train with prices starting from $24. For those with little time consider booking a train which can get you there in 4h 45m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.3kg. The ticket price range depends on the travel mode: a train costs an average of $24, and a bus costs an average of $32.
Distance: 182 miles (294 km)
| Bus | Most popular Train | Driving |
|---|---|---|
$34 Average price | $31 Average price Cheapest | $80 Average price (fuel + tolls) |
7h 23m Average total duration 6h 53m Onboard + 30m Additional time* | 5h 15m Average total duration Fastest 4h 45m Onboard + 30m Additional time* | 4h 6m Average total duration (door-to-door) |
0.3 - 0.7kg CO2 emissions | 0.1 - 0.3kg CO2 emissions Lowest | - CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mendrisio to Florence:
A train is $4 (€3) less than a bus for this route with tickets for a bus from Mendrisio to Florence costing on average $34 (€28).
Other travel options to Florence take longer:
Bus takes on average 6h 53m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Itabus | Departure Time 07:45PM | Arrival Time 02:10AM | Duration 6h25 | Departure days Sat | Cheapest price $32 |
Operator Itabus | Departure Time 07:50PM | Arrival Time 03:10AM | Duration 7h20 | Departure days Thu | Cheapest price $36 |
The table below shows live departures for Mendrisio to Florence buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:45 PM Mendrisio | 6h25 | 2:10 AM Florence | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Mendrisio to Florence run on average 11 times per day, taking around 6h 53m. Cheap bus tickets for this journey start at $32 (€26) but you can travel from only $24 (€20) by train.
There are 7 buses per day. The earliest bus runs at 00:50, the last at 23:40. The fastest bus covers the 182 miles (294 km) distance in 6h 25m.
Distance 182 miles (294 km) |
Average bus duration 6h 53m |
Cheapest ticket price $32 (€26) |
Buses per day 11 |
Direct buses 7 |
Fastest bus 6h 25m |
First bus 12:50 AM |
Last bus 11:40 PM |
Cheapest Month Sep |
Cheapest Day Fri |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Fri |
Best time to book 63 days |
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
Florence’s premier art museum, famed for Renaissance masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. One of Italy’s essential museum visits.
Best known for Michelangelo’s David, this museum also holds important Florentine paintings and sculpture. Advance booking is strongly advisable.
Vast palace museum complex with royal apartments, Palatine Gallery, and decorative arts. A major stop for art, Medici history, and grand interiors.
Florence’s monumental heart, where the cathedral, baptistery, and bell tower stand together. Essential for first-time visitors and photographers.
Historic civic square filled with sculpture and dominated by Palazzo Vecchio. One of the city’s most important and lively public spaces.
Florence’s most famous viewpoint, especially popular at sunset and widely shared on social media for its sweeping skyline panorama.
A Thick-Cut T-Bone Steak From Chianina Beef, Grilled Rare Over Coals. It Is Florence’s Signature Dish And A Classic Of Tuscan Cuisine.
A Traditional Florentine Street Food Made From The Fourth Stomach Of The Cow, Slow-Cooked In Broth And Served In A Roll, Often With Green Sauce.
A Rustic Tomato, Bread, Garlic, And Olive Oil Soup. It Is A Beloved Tuscan Dish That Turns Stale Bread Into Rich Comfort Food.
A Michelin-Starred Restaurant Offering Refined Tuscan Cuisine With Creative Technique, Elegant Service, And A Contemporary Fine-Dining Atmosphere.
A Small, Long-Running Florentine Favorite Known For Traditional Cooking, Especially Butter Chicken And Simple Tuscan Classics In An Old-School Setting.
A Historic, Casual Trattoria Near Mercato Centrale, Famous For Bistecca Alla Fiorentina, Tuscan Soups, And A Lively Local Atmosphere.
Generally moderate for Italy: museums and central hotels cost more, while casual food and coffee remain fairly affordable.
Service is often included or covered by a coperto. Tipping is not required, but leaving EUR 1-2 at cafes or 5-10% for excellent restaurant service is appreciated.
Official public transport app
Scandicci Villa Costanza, Florence -> Firenze Santa Maria Novella, Florence
Find answers to the most common questions about traveling from Mendrisio to Florence by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, this guide helps you travel smarter and with confidence.

Most Mendrisio to Florence buses use the Como, Piazzale San Gottardo (Stazione San Giovanni) to Scandicci, Villa Costanza (Firenze) station pair, with some services arriving at Florence, Guidoni Tram T2. Use this guide to compare Mendrisio and Florence bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Scandicci, Villa Costanza (Firenze) is 1 km from Florence city centre. Public transport options include:
Scandicci, Villa Costanza (Firenze) has practical services for this route, including Wifi, Parking, ATM, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located near the entrance.
Ticket office support is available at Scandicci, Villa Costanza (Firenze).
Available at Scandicci, Villa Costanza (Firenze): Parking, WC.
Accessibility facilities are available at Scandicci, Villa Costanza (Firenze): Elevators, ramps.
Firenze, Piazzale Montelungo is 1 km from Florence city centre. Public transport options include:
Firenze, Piazzale Montelungo has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located near the entrance.
Ticket office support is available at Firenze, Piazzale Montelungo.
Available at Firenze, Piazzale Montelungo: Parking, Taxis, WC.
Accessibility facilities are available at Firenze, Piazzale Montelungo: Elevators, ramps.
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