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Travel optionsfrom Mendrisio to Florence
How to get from Mendrisio to Florence by train, bus or flight.
Our recommendation
The best way to travel from Mendrisio to Florence is by taking a bus because it’s the best combination of price and speed.
7:45 PM6h25Mendrisio2:10 AMFlorence$321One-way0 transfers
Cheapest
7:45 PM6h25Mendrisio2:10 AMFlorence$321One-way0 transfers
Fastest
7:45 PM6h25Mendrisio2:10 AMFlorence$321One-way0 transfers
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FAQs: Travel from Mendrisio to Florence
Travel to Florence easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Mendrisio to Florence.

There are 2 options to travel between Mendrisio and Florence including taking a train and bus.
The distance from Mendrisio to Florence is approximately 182 miles (294 km).
These are the most popular departure and arrival points from Mendrisio to Florence:
- Flights mostly depart from Milan Linate Airport and arrive in Florence Peretola Airport.
- Trains mostly depart from Milan Centrale and arrive in Florence Santa Maria Novella.
- Buses mostly depart from Como, Via Colombo Cristoforo (Grandate FNM) and arrive in Scandicci, Villa Costanza (Florence).
If finding a good deal is your main consideration for your trip from Mendrisio to Florence, then we'll help you find the best value travel companies for you:
- Travel with Regionale, Intercity, Italo, Swiss Federal Railways (SBB CFF FFS) to go to Florence by train.
Yes, there is a direct route available from Mendrisio to Florence:
- 0 direct trains per day with Italo.
Omio customers who travel from Mendrisio to Florence often also extend their vacation to go to Rome, Pisa, Venice, Milan, Bologna. Omio can help you plan your trip by finding the best connections between Florence and these popular destinations at a great price.
Most travelers need at least three days in Florence to see the main sights at a comfortable pace. If you want day trips or a slower itinerary, consider adding extra time.
In Florence, you can climb to Piazzale Michelangelo for panoramic views of the city's skyline, visit the Accademia Gallery to see Michelangelo's David, and take a cooking class to master traditional Tuscan dishes. Enjoy a wine tasting tour in the Chianti region and explore the vibrant San Lorenzo Market. Don't miss the iconic Florence Cathedral with its stunning dome, the Uffizi Gallery for masterpieces by Botticelli and Michelangelo, and Ponte Vecchio for its historic charm. Visit Palazzo Vecchio, a medieval fortress-palace, and the elegant Boboli Gardens behind Pitti Palace.
To fully experience Florence, plan for at least 3 to 4 days to explore its rich history, art, and architecture, including must-sees like the Uffizi Gallery, Florence Cathedral, and Ponte Vecchio.
Travelling from Mendrisio to Florence: related information
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