- Must visit
Edison and Ford Winter Estates Museum
Major local museum at the Edison and Ford estates with inventions, automobiles, and exhibits on two influential American innovators.
Cheapest price
$382
Average price
$389
Fastest journey
2 d 4 h 15 m
Average duration
2 d 4 h 15 m
Buses per day
2
Distance
2049 km
The best way to find a cheap bus ticket from Manchester, NH to Fort Myers, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Manchester, NH to Fort Myers, FL will cost around $389 if you buy it on the day, but the cheapest tickets can be found for only $382.
Of the 2 buses that leave Manchester, NH for Fort Myers, FL on Wed, Aug 05, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 2049 km distance in an average of 2 d 4 h 15 m but if you time it right, some buses will get you there in just 2 d 4 h 15 m .
On Wed, Aug 05 the slowest buses will take 2 d 4 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the bus as it is the most popular option from Manchester, NH to Fort Myers, FL among Omio's users. If you are prioritising price take the flight with prices starting from $165. For those with little time consider booking a flight which can get you there in 7h 26m. The ticket price range depends on the travel mode: a flight costs an average of $165, and a train costs an average of $765.
Distance: 1273 miles (2049 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$413 Average price | $355 Average price Cheapest | $765 Average price | $331 Average price (fuel + tolls) |
38h 10m Average total duration 37h 40m Onboard + 30m Additional time* | 10h 26m Average total duration Fastest 7h 26m Onboard + 3h 0m Additional time* | 36h 45m Average total duration 36h 15m Onboard + 30m Additional time* | 22h 31m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Manchester, NH to Fort Myers, FL:
A flight is $58 less than a bus for this route with tickets for a bus from Manchester, NH to Fort Myers, FL costing on average $413.
A flight is $411 less than a train for this route with tickets for a train from Manchester, NH to Fort Myers, FL costing on average $765.
Other travel options to Fort Myers, FL take longer:
Train takes on average 36h 15m.
Bus takes on average 37h 40m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 10:05AM | Arrival Time 02:20PM | Duration 52h15 | Departure days Tue, Wed, Thu | Cheapest price $313 |
Operator Greyhound | Departure Time 11:05AM | Arrival Time 03:20PM | Duration 52h15 | Departure days Wed, Thu, Fri, Sat | Cheapest price $382 |
Operator FlixBus | Departure Time 07:35PM | Arrival Time 08:20PM | Duration 48h45 | Departure days Mon, Fri, Sun | Cheapest price $363 |
Operator FlixBus | Departure Time 10:30PM | Arrival Time 09:20PM | Duration 46h50 | Departure days Fri | Cheapest price $422 |
The table below shows live departures for Manchester, NH to Fort Myers, FL buses for today, Tuesday, August 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 10:05 AM Manchester, NH | 52h15 | 2:20 PM Fort Myers, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, flight, and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Manchester, NH to Fort Myers, FL run on average 3 times per day, taking around 37h 40m. Cheap bus tickets for this journey start at $313 but you can travel from only $165 by flight.
The earliest bus runs at 07:05, the last at 18:30. The fastest bus covers the 1273 miles (2049 km) distance in 46h 50m.
Distance 1273 miles (2049 km) |
Average bus duration 37h 40m |
Cheapest ticket price $313 |
Buses per day 3 |
Fastest bus 46h 50m |
First bus 7:05 AM |
Last bus 6:30 PM |
Cheapest Month Nov |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of Fort Myers, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Fort Myers, FL trip today.
Major local museum at the Edison and Ford estates with inventions, automobiles, and exhibits on two influential American innovators.
Excellent regional history museum covering Southwest Florida's people, places, and development through engaging permanent exhibitions.
Interactive science museum with aquariums, live animals, and hands-on exhibits that make it especially strong for families and curious adults.
Walkable historic downtown filled with shops, galleries, event spaces, and river views, making it the city's main strolling district.
Large urban nature preserve with boardwalks, trails, and birding, offering a wild contrast to the built-up city center.
Palm-lined downtown street known for preserved architecture, boutiques, murals, and an easy introduction to the city's historic core.
Fresh Gulf shrimp, often peeled and eaten chilled or quickly sautéed. A Southwest Florida staple thanks to nearby shrimping waters and seafood culture.
A Florida classic of flaky local fish, usually grouper, served blackened, grilled, or fried in a sandwich. Popular along Fort Myers waterfronts.
Cracked Florida stone crab claws served chilled with mustard sauce. A prized seasonal seafood known across coastal South Florida and the Gulf.
Established fine dining restaurant serving refined seafood and steaks in an elegant historic downtown setting.
Casual waterfront seafood spot known for fresh local shrimp, grouper, and island atmosphere near the marina.
Beloved local Cuban cafe offering pressed sandwiches, coffee, pastries, and traditional Latin comfort food in a casual setting.
Moderate for Florida beach travel. Hotels and dining run mid-range, while car travel and parking add costs. Cheaper than Miami, but pricier than many inland US cities.
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 per drink or coffee in cafes and bars.
Find answers to the most common questions about traveling from Manchester, NH to Fort Myers, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Fort Myers, FL, this guide helps you travel smarter and with confidence.

Most Manchester, NH to Fort Myers, FL buses use the Manchester to Fort Myers, Rosa Parks Transit Center station pair. Use this guide to compare Manchester, NH and Fort Myers, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need