- Must visit
Edison and Ford Winter Estates Museum
Major local museum at the Edison and Ford estates with inventions, automobiles, and exhibits on two influential American innovators.
The best way to find a cheap bus ticket from Houston, TX to Fort Myers, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Houston, TX to Fort Myers, FL will cost around $137 if you buy it on the day, but the cheapest tickets can be found for only $132.
It's difficult to get from Houston, TX to Fort Myers, FL without transferring at least 2 times.
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Buses from Houston, TX to Fort Myers, FL run on average 5 times per day, taking around 33h 57m. Cheap bus tickets for this journey start at $106 if you book in advance.
The earliest bus runs at 00:05, the last at 22:50. The fastest bus covers the 851 miles (1370 km) distance in 26h 40m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Houston, TX to Fort Myers, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:00AM | Arrival Time 04:35PM | Duration 34h35 | Departure days Everyday | Cheapest price $111 |
Operator Greyhound | Departure Time 06:35AM | Arrival Time 10:20AM | Duration 50h45 | Departure days Mon, Thu, Sun | Cheapest price $114 |
Operator Greyhound | Departure Time 10:25AM | Arrival Time 10:20AM | Duration 46h55 | Departure days Thu | Cheapest price $149 |
Operator Greyhound | Departure Time 11:30AM | Arrival Time 10:20AM | Duration 45h50 | Departure days Tue | Cheapest price $139 |
Operator Greyhound | Departure Time 01:15PM | Arrival Time 10:20AM | Duration 44h05 | Departure days Tue | Cheapest price $135 |
Operator Greyhound | Departure Time 01:40PM | Arrival Time 10:20AM | Duration 43h40 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $113 |
Operator Greyhound | Departure Time 01:45PM | Arrival Time 10:20AM | Duration 43h35 | Departure days Wed, Fri, Sat | Cheapest price $114 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 04:35PM | Duration 48h50 | Departure days Fri | Cheapest price $118 |
Operator Greyhound | Departure Time 05:35PM | Arrival Time 04:35PM | Duration 46h00 | Departure days Tue, Wed, Sat | Cheapest price $115 |
Operator Greyhound | Departure Time 06:00PM | Arrival Time 04:35PM | Duration 45h35 | Departure days Tue | Cheapest price $143 |
Operator Greyhound | Departure Time 10:00PM | Arrival Time 10:20AM | Duration 35h20 | Departure days Everyday | Cheapest price $109 |
Operator Greyhound | Departure Time 10:50PM | Arrival Time 10:20AM | Duration 34h30 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $109 |
The table below shows live departures for Houston, TX to Fort Myers, FL buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
+ FlixBus · FlixBus | 5:00 AM Houston, Harrisburg Blvd (Greyhound Bus Station), TX | 34h35 | 4:35 PM Fort Myers, Rosa Parks Transit Center | 2 transfers | |
· + FlixBus · FlixBus | 6:35 AM Houston, Southwest Fwy (Chevron), TX | 50h45 | 10:20 AM Fort Myers, Rosa Parks Transit Center | 4 transfers | |
FlixBus+ + FlixBus · FlixBus | 1:40 PM North Houston (Tidwell Transit Center), TX | 43h40 | 10:20 AM Fort Myers, Rosa Parks Transit Center | 3 transfers | |
+ FlixBus · FlixBus | 10:00 PM Houston, Harrisburg Blvd (Greyhound Bus Station), TX | 35h20 | 10:20 AM Fort Myers, Rosa Parks Transit Center | 2 transfers | |
FlixBus+ + FlixBus · FlixBus | 10:50 PM Houston, Gray St Parking (Bus Station), TX | 34h30 | 10:20 AM Fort Myers, Rosa Parks Transit Center | 3 transfers |
Find all the dates and times for this journey
Buses from Houston, TX to Fort Myers, FL with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Fort Myers, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Fort Myers, FL trip today.
Major local museum at the Edison and Ford estates with inventions, automobiles, and exhibits on two influential American innovators.
Excellent regional history museum covering Southwest Florida's people, places, and development through engaging permanent exhibitions.
Interactive science museum with aquariums, live animals, and hands-on exhibits that make it especially strong for families and curious adults.
Walkable historic downtown filled with shops, galleries, event spaces, and river views, making it the city's main strolling district.
Large urban nature preserve with boardwalks, trails, and birding, offering a wild contrast to the built-up city center.
Palm-lined downtown street known for preserved architecture, boutiques, murals, and an easy introduction to the city's historic core.
Fresh Gulf shrimp, often peeled and eaten chilled or quickly sautéed. A Southwest Florida staple thanks to nearby shrimping waters and seafood culture.
A Florida classic of flaky local fish, usually grouper, served blackened, grilled, or fried in a sandwich. Popular along Fort Myers waterfronts.
Cracked Florida stone crab claws served chilled with mustard sauce. A prized seasonal seafood known across coastal South Florida and the Gulf.
Established fine dining restaurant serving refined seafood and steaks in an elegant historic downtown setting.
Casual waterfront seafood spot known for fresh local shrimp, grouper, and island atmosphere near the marina.
Beloved local Cuban cafe offering pressed sandwiches, coffee, pastries, and traditional Latin comfort food in a casual setting.
Moderate for Florida beach travel. Hotels and dining run mid-range, while car travel and parking add costs. Cheaper than Miami, but pricier than many inland US cities.
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 per drink or coffee in cafes and bars.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Fort Myers, FL.
Find answers to the most common questions about traveling from Houston, TX to Fort Myers, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Fort Myers, FL, this guide helps you travel smarter and with confidence.

Most Houston, TX to Fort Myers, FL buses use the Houston, Harrisburg Blvd (Greyhound Bus Station) to Fort Myers, Rosa Parks Transit Center station pair. Use this guide to compare Houston, TX and Fort Myers, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Houston, Harrisburg Blvd (Greyhound Bus Station) is 6 km from Houston city centre. Public transport options include:
Houston, Harrisburg Blvd (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Houston, Harrisburg Blvd (Greyhound Bus Station). ATMs are aTM available in the waiting area.
Ticket office support is available at Houston, Harrisburg Blvd (Greyhound Bus Station).
Available at Houston, Harrisburg Blvd (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Houston, Harrisburg Blvd (Greyhound Bus Station): Wheelchair accessible entrances and facilities.
Houston, Gray St Parking (Bus Station) is 1 km from Houston city centre. Public transport options include:
Houston, Gray St Parking (Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Restaurants are available nearby.
Wi-Fi is available at Houston, Gray St Parking (Bus Station). ATMs are available at Houston, Gray St Parking (Bus Station).
Ticket office support is available at Houston, Gray St Parking (Bus Station).
Available at Houston, Gray St Parking (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Houston, Gray St Parking (Bus Station): The station is accessible for disabled passengers.
Houston, Southwest Fwy (Chevron) is 14 km from Houston city centre. Public transport options include:
Houston, Southwest Fwy (Chevron) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Houston, Southwest Fwy (Chevron). ATMs are available at Houston, Southwest Fwy (Chevron).
Ticket office support is available at Houston, Southwest Fwy (Chevron).
Available at Houston, Southwest Fwy (Chevron): Parking, Taxis, WC.
Accessibility facilities are available at Houston, Southwest Fwy (Chevron): Wheelchair accessible.
Fort Myers, Rosa Parks Transit Center is 3 km from Fort Myers city centre. Public transport options include:
Fort Myers, Rosa Parks Transit Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Fort Myers, Rosa Parks Transit Center. ATMs are available at Fort Myers, Rosa Parks Transit Center.
Ticket office support is available at Fort Myers, Rosa Parks Transit Center.
Available at Fort Myers, Rosa Parks Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at Fort Myers, Rosa Parks Transit Center: Wheelchair accessible routes provided.
Check bus stations information for Houston, TX and Fort Myers, FL, including where buses depart and arrive on this route.