- Must visit
Villa Tugendhat
Modernist villa by Mies van der Rohe, listed by UNESCO. An essential architecture visit for its groundbreaking open-plan interior.
Cheapest price on Sep 18
€12
Average ticket price on Sep 18
€23
Fastest journey on Sep 18
4 h 50 m
Average journey duration on Sep 18
5 h 17 m
Buses on Sep 18
21
Distance
292 km
The best way to find a cheap bus ticket from Karlovy Vary to Brno is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlovy Vary to Brno will cost around €23 if you buy it on the day, but the cheapest tickets can be found for only €12.
On Fri, Sep 18, we found 21 buses from Karlovy Vary to Brno, including 2 direct services.
On Fri, Sep 18 the direct buses cover the 292 km distance in an average of 5 h 17 m but if you time it right, some buses will get you there in just 4 h 50 m .
On Fri, Sep 18 the slowest buses will take 5 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus
(Karlovy Vary -> Prague) · (Prague -> Brno)
(Cheb -> Prague) · (Prague -> Vienna)
(Karlovy Vary -> Prague) · (Prague -> Brno)
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
(Cheb -> Prague) · (Prague -> Budapest)
(Cheb -> Prague) · (Prague -> Vienna)Omio recommends booking the train as it is the most popular option from Karlovy Vary to Brno among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €18 For those with little time, consider booking a bus, which has an average total journey time of 5h 27m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.3kg. Average ticket prices depend on the travel mode: a bus costs an average of €18, while a train costs an average of €28.
Distance: 181 miles (292 km)
| Bus | Most popular Train | Driving |
|---|---|---|
€18 Average price Cheapest | €28 Average price | €64 Average price (fuel + tolls) |
5h 27m Average total duration Fastest 4h 57m Onboard + 30m Additional time* | 6h 39m Average total duration 6h 9m Onboard + 30m Additional time* | 3h 34m Average total duration (door-to-door) |
0.3 - 0.7kg CO2 emissions | 0.1 - 0.3kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Karlovy Vary to Brno:
A bus is €10 less than a train for this route with tickets for a train from Karlovy Vary to Brno costing on average €28.
Other travel options to Brno take longer:
Train takes on average 6h 9m.
Tickets start at around €18 compared to roughly €64 in fuel and tolls — a saving of about €46. The journey takes 4h 57m versus 3h 34m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator RegioJet a.s. | Departure Time 05:00AM | Arrival Time 10:55AM | Duration 5h55 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price €8 |
Operator FlixBus | Departure Time 05:30AM | Arrival Time 11:00AM | Duration 5h30 | Departure days Thu | Cheapest price €19 |
Operator FlixBus | Departure Time 05:55AM | Arrival Time 12:10PM | Duration 6h15 | Departure days Everyday | Cheapest price €12 |
Operator RegioJet a.s. | Departure Time 06:00AM | Arrival Time 12:00PM | Duration 6h00 | Departure days Everyday | Cheapest price €9 |
Operator FlixBus | Departure Time 06:15AM | Arrival Time 12:10PM | Duration 5h55 | Departure days Everyday | Cheapest price €14 |
Operator RegioJet a.s. | Departure Time 07:00AM | Arrival Time 12:55PM | Duration 5h55 | Departure days Everyday | Cheapest price €9 |
Operator FlixBus | Departure Time 07:35AM | Arrival Time 01:20PM | Duration 5h45 | Departure days Thu | Cheapest price €20 |
Operator RegioJet a.s. | Departure Time 08:00AM | Arrival Time 01:30PM | Duration 5h30 | Departure days Everyday | Cheapest price €10 |
Operator FlixBus | Departure Time 09:30AM | Arrival Time 02:40PM | Duration 5h10 | Departure days Everyday | Cheapest price €14 |
Operator RegioJet a.s. | Departure Time 10:00AM | Arrival Time 03:55PM | Duration 5h55 | Departure days Everyday | Cheapest price €9 |
Operator RegioJet a.s. | Departure Time 11:00AM | Arrival Time 04:55PM | Duration 5h55 | Departure days Everyday | Cheapest price €9 |
Operator FlixBus | Departure Time 11:30AM | Arrival Time 05:10PM | Duration 5h40 | Departure days Everyday | Cheapest price €14 |
Operator FlixBus | Departure Time 12:30PM | Arrival Time 06:05PM | Duration 5h35 | Departure days Everyday | Cheapest price €14 |
Operator RegioJet a.s. | Departure Time 01:00PM | Arrival Time 06:55PM | Duration 5h55 | Departure days Everyday | Cheapest price €10 |
Operator RegioJet a.s. | Departure Time 02:00PM | Arrival Time 07:55PM | Duration 5h55 | Departure days Everyday | Cheapest price €10 |
Operator RegioJet a.s. | Departure Time 03:00PM | Arrival Time 08:30PM | Duration 5h30 | Departure days Everyday | Cheapest price €10 |
Operator RegioJet a.s. | Departure Time 04:00PM | Arrival Time 09:55PM | Duration 5h55 | Departure days Everyday | Cheapest price €8 |
Operator FlixBus | Departure Time 04:10PM | Arrival Time 09:00PM | Duration 4h50 | Departure days Everyday | Cheapest price €12 |
Operator RegioJet a.s. | Departure Time 05:00PM | Arrival Time 10:55PM | Duration 5h55 | Departure days Everyday | Cheapest price €8 |
Operator RegioJet a.s. | Departure Time 06:00PM | Arrival Time 04:00AM | Duration 10h00 | Departure days Fri | Cheapest price €28 |
Operator RegioJet a.s. | Departure Time 08:00PM | Arrival Time 01:30AM | Duration 5h30 | Departure days Everyday | Cheapest price €10 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 01:55AM | Duration 5h25 | Departure days Fri, Sat, Sun | Cheapest price €21 |
The table below shows live departures for Karlovy Vary to Brno buses for today, Thursday, September 17. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
(Karlovy Vary -> Prague) · (Prague -> Brno) | 5:00 PM Karlovy Vary, Dolní Nádraží | 5h55 | 10:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Cheb -> Prague) · (Prague -> Budapest) | 8:00 PM Karlovy Vary, Dolní Nádraží | 5h30 | 1:30 AM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
| Friday, September 18 | |||||
(Karlovy Vary -> Prague) · (Prague -> Brno) | 5:00 AM Karlovy Vary, Dolní Nádraží | 5h55 | 10:55 AM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
FlixBus | 5:55 AM Karlovy Vary, Dolní Nádraží | 6h15 | 12:10 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 0 transfersDirect | |
(Cheb -> Prague) · (Prague -> Budapest) | 6:00 AM Karlovy Vary, Dolní Nádraží | 6h00 | 12:00 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
FlixBus · FlixBus | 6:15 AM Karlovy Vary, Dolní Nádraží | 5h55 | 12:10 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Karlovy Vary -> Prague) · (Prague -> Brno) | 7:00 AM Karlovy Vary, Dolní Nádraží | 5h55 | 12:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Cheb -> Prague) · (Prague -> Vienna) | 8:00 AM Karlovy Vary, Dolní Nádraží | 5h30 | 1:30 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
FlixBus · FlixBus | 9:30 AM Karlovy Vary, Dolní Nádraží | 5h10 | 2:40 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Karlovy Vary -> Prague) · (Prague -> Brno) | 10:00 AM Karlovy Vary, Dolní Nádraží | 5h55 | 3:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Karlovy Vary -> Prague) · (Prague -> Brno) | 11:00 AM Karlovy Vary, Dolní Nádraží | 5h55 | 4:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
FlixBus · FlixBus | 11:30 AM Karlovy Vary, Dolní Nádraží | 5h40 | 5:10 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
FlixBus · FlixBus | 12:30 PM Karlovy Vary, Dolní Nádraží | 5h35 | 6:05 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Karlovy Vary -> Prague) · (Prague -> Brno) | 1:00 PM Karlovy Vary, Dolní Nádraží | 5h55 | 6:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Karlovy Vary -> Prague) · (Prague -> Brno) | 2:00 PM Karlovy Vary, Dolní Nádraží | 5h55 | 7:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Karlovy Vary -> Prague) · (Prague -> Vienna) | 3:00 PM Karlovy Vary, Dolní Nádraží | 5h30 | 8:30 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Cheb -> Prague) · (Prague -> Brno) | 4:00 PM Karlovy Vary, Dolní Nádraží | 5h55 | 9:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
FlixBus | 4:10 PM Karlovy Vary, Dolní Nádraží | 4h50 | 9:00 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Karlovy Vary to Brno run on average 6 times per day, taking around 4h 57m. Cheap bus tickets for this journey start at €6 if you book in advance.
There are 2 buses per day. The earliest bus runs at 03:15, the last at 21:20. The fastest bus covers the 181 miles (292 km) distance in 4h 35m.
Distance 181 miles (292 km) |
Average bus duration 4h 57m |
Cheapest ticket price €6 |
Buses per day 6 |
Direct buses 2 |
Fastest bus 4h 35m |
First bus 3:15 AM |
Last bus 9:20 PM |
Cheapest Month Feb |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Wed |
Best time to book 1 day |
Discover the best of Brno — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brno trip today.
Modernist villa by Mies van der Rohe, listed by UNESCO. An essential architecture visit for its groundbreaking open-plan interior.
Brno’s city museum inside Špilberk Castle, covering local history, art, and prison heritage in a dramatic hilltop complex.
Major regional museum with natural science, history, and temporary exhibitions. A strong choice for understanding Moravia in context.
Brno’s main central square, lined with historic facades, events, and public art. A practical meeting point and key place to feel the city.
Historic market square with colorful townhouses, the Parnas fountain, and regular produce and festive markets. One of Brno’s liveliest areas.
Prominent hill around the cathedral, with calm lanes and viewpoints over the old town. Ideal for short walks and classic Brno panoramas.
Brno's classic bun filled with whipped cream. It is a beloved local pastry tied to the city's café culture and everyday sweet eating.
Pork schnitzel with potato salad is a Czech staple widely loved in Brno for family meals, pubs, and festive gatherings.
Roast beef in creamy root vegetable sauce with bread dumplings. A cornerstone Czech dish commonly served in traditional Brno restaurants.
Fine dining restaurant with modern Czech and Central European tasting menus in an elegant, contemporary setting.
Well-known restaurant and wine bar focused on Moravian ingredients, seasonal cooking, and a polished but relaxed atmosphere.
Traditional Brno restaurant by Špilberk Castle known for Czech dishes, local beer, and a historic cellar atmosphere.
More affordable than Prague and many Western European cities. Dining and transit are low-cost, while central hotels are moderate in peak periods.
Service is often not included. Round up or tip 5-10% in restaurants. Round up small taxi fares and leave small change in cafes if service is good.
Official public transport app
Brno, Benešova - Grandhotel (Hlavní nádraží) -> Náměstí Svobody, Brno
Find answers to the most common questions about traveling from Karlovy Vary to Brno by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brno, this guide helps you travel smarter and with confidence.

Most Karlovy Vary to Brno buses use the Karlovy Vary, Dolní Nádraží to Brno, Benešova - Grandhotel (Hlavní nádraží) station pair. Use this guide to compare Karlovy Vary and Brno bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Karlovy Vary, Dolní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Dolní (in the station), Fast Food Express (in the station), Coffee Corner (in the station).
Free Wi-Fi. ATMs are located near the entrance.
Ticket office support is available at Karlovy Vary, Dolní Nádraží.
Available at Karlovy Vary, Dolní Nádraží: Parking, WC.
Accessibility facilities are available at Karlovy Vary, Dolní Nádraží: Elevators, ramps.
Brno, Benešova - Grandhotel (Hlavní nádraží) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located inside the station.
Ticket office support is available at Brno, Benešova - Grandhotel (Hlavní nádraží).
Available at Brno, Benešova - Grandhotel (Hlavní nádraží): Parking, Taxis, WC.
Accessibility facilities are available at Brno, Benešova - Grandhotel (Hlavní nádraží): Elevators, ramps.
Here are some other resources that might have the information you need