- Must visit
Villa Tugendhat
Modernist villa by Mies van der Rohe, listed by UNESCO. An essential architecture visit for its groundbreaking open-plan interior.
Cheapest price
$10
Average price
$14
Fastest journey
4 h 50 m
Average duration
6 h 21 m
Buses per day
4
Distance
292 km
The best way to find a cheap bus ticket from Karlovy Vary to Brno is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlovy Vary to Brno will cost around $14 if you buy it on the day, but the cheapest tickets can be found for only $10.
Of the 4 buses that leave Karlovy Vary for Brno on Tue, Aug 04, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Aug 04 the direct buses cover the 292 km distance in an average of 6 h 21 m but if you time it right, some buses will get you there in just 4 h 50 m .
On Tue, Aug 04 the slowest buses will take 7 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Buses from Karlovy Vary to Brno run on average 16 times per day, taking around 5h 2m. Cheap bus tickets for this journey start at $8 (€6) if you book in advance.
There are 1 buses per day. The earliest bus runs at 03:15, the last at 21:20. The fastest bus covers the 181 miles (292 km) distance in 4h 50m.
Distance 181 miles (292 km) |
Average bus duration 5h 2m |
Cheapest ticket price $8 (€6) |
Buses per day 16 |
Direct buses 1 |
Fastest bus 4h 50m |
First bus 3:15 AM |
Last bus 9:20 PM |
Cheapest Month Feb |
Cheapest Day Tue |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Sat |
Least Busy Day Sun |
Best time to book 1 day |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:55AM | Arrival Time 10:10AM | Duration 6h15 | Departure days Fri, Sat | Cheapest price $17 |
Operator RegioJet a.s. | Departure Time 05:00AM | Arrival Time 10:55AM | Duration 5h55 | Departure days Wed, Thu | Cheapest price $21 |
Operator FlixBus | Departure Time 05:15AM | Arrival Time 11:10AM | Duration 5h55 | Departure days Fri, Sat | Cheapest price $13 |
Operator FlixBus | Departure Time 05:55AM | Arrival Time 12:10PM | Duration 6h15 | Departure days Wed, Thu, Sun | Cheapest price $17 |
Operator RegioJet a.s. | Departure Time 06:00AM | Arrival Time 12:00PM | Duration 6h00 | Departure days Wed, Thu, Sun | Cheapest price $22 |
Operator FlixBus | Departure Time 06:15AM | Arrival Time 12:10PM | Duration 5h55 | Departure days Wed, Thu, Sun | Cheapest price $17 |
Operator RegioJet a.s. | Departure Time 07:00AM | Arrival Time 12:55PM | Duration 5h55 | Departure days Wed, Thu, Sun | Cheapest price $22 |
Operator FlixBus | Departure Time 07:30AM | Arrival Time 02:30PM | Duration 7h00 | Departure days Tue, Fri | Cheapest price $19 |
Operator RegioJet a.s. | Departure Time 08:00AM | Arrival Time 01:30PM | Duration 5h30 | Departure days Wed, Thu, Sun | Cheapest price $24 |
Operator FlixBus | Departure Time 08:30AM | Arrival Time 03:30PM | Duration 7h00 | Departure days Tue, Sat | Cheapest price $12 |
Operator FlixBus | Departure Time 09:30AM | Arrival Time 04:05PM | Duration 6h35 | Departure days Mon, Wed, Thu, Fri, Sun | Cheapest price $17 |
Operator RegioJet a.s. | Departure Time 10:00AM | Arrival Time 03:55PM | Duration 5h55 | Departure days Mon, Wed, Thu, Sun | Cheapest price $22 |
Operator RegioJet a.s. | Departure Time 11:00AM | Arrival Time 04:55PM | Duration 5h55 | Departure days Mon, Wed, Thu, Sun | Cheapest price $22 |
Operator FlixBus | Departure Time 11:30AM | Arrival Time 05:10PM | Duration 5h40 | Departure days Mon, Wed, Thu, Sun | Cheapest price $18 |
Operator FlixBus | Departure Time 12:30PM | Arrival Time 06:05PM | Duration 5h35 | Departure days Mon, Wed, Thu, Sun | Cheapest price $17 |
Operator RegioJet a.s. | Departure Time 01:00PM | Arrival Time 06:55PM | Duration 5h55 | Departure days Mon, Wed, Thu, Sun | Cheapest price $22 |
Operator RegioJet a.s. | Departure Time 02:00PM | Arrival Time 07:55PM | Duration 5h55 | Departure days Mon, Wed, Thu, Sun | Cheapest price $26 |
Operator FlixBus | Departure Time 02:10PM | Arrival Time 07:00PM | Duration 4h50 | Departure days Sat | Cheapest price $17 |
Operator RegioJet a.s. | Departure Time 03:00PM | Arrival Time 08:30PM | Duration 5h30 | Departure days Mon, Wed, Thu, Sun | Cheapest price $22 |
Operator FlixBus | Departure Time 03:10PM | Arrival Time 08:00PM | Duration 4h50 | Departure days Tue | Cheapest price $16 |
Operator RegioJet a.s. | Departure Time 04:00PM | Arrival Time 09:55PM | Duration 5h55 | Departure days Mon, Wed, Thu, Sun | Cheapest price $23 |
Operator FlixBus | Departure Time 04:10PM | Arrival Time 09:00PM | Duration 4h50 | Departure days Mon, Wed, Thu, Sun | Cheapest price $17 |
Operator FlixBus | Departure Time 04:30PM | Arrival Time 11:05PM | Duration 6h35 | Departure days Tue | Cheapest price $10 |
Operator RegioJet a.s. | Departure Time 05:00PM | Arrival Time 10:55PM | Duration 5h55 | Departure days Mon, Wed, Thu, Sun | Cheapest price $23 |
Operator FlixBus | Departure Time 05:30PM | Arrival Time 12:05AM | Duration 6h35 | Departure days Sat | Cheapest price $13 |
Operator RegioJet a.s. | Departure Time 08:00PM | Arrival Time 01:30AM | Duration 5h30 | Departure days Mon, Wed, Thu, Sun | Cheapest price $26 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 01:55AM | Duration 5h25 | Departure days Sun | Cheapest price $45 |
The table below shows live departures for Karlovy Vary to Brno buses for today, Monday, August 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
(Karlovy Vary -> Prague) · (Prague -> Brno) | 2:00 PM Karlovy Vary, Dolní Nádraží | 5h55 | 7:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Karlovy Vary -> Prague) · (Prague -> Vienna) | 3:00 PM Karlovy Vary, Dolní Nádraží | 5h30 | 8:30 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Cheb -> Prague) · (Prague -> Brno) | 4:00 PM Karlovy Vary, Dolní Nádraží | 5h55 | 9:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
FlixBus | 4:10 PM Karlovy Vary, Dolní Nádraží | 4h50 | 9:00 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 0 transfersDirect | |
(Karlovy Vary -> Prague) · (Prague -> Brno) | 5:00 PM Karlovy Vary, Dolní Nádraží | 5h55 | 10:55 PM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
(Cheb -> Prague) · (Prague -> Budapest) | 8:00 PM Karlovy Vary, Dolní Nádraží | 5h30 | 1:30 AM Brno, Benešova - Grandhotel (Hlavní nádraží) | 1 transfer | |
| Tuesday, August 4 | |||||
![]() | 7:30 AM Karlovy Vary | 7h00 | 2:30 PM Brno | 0 transfersDirect | |
![]() | 8:30 AM Karlovy Vary | 7h00 | 3:30 PM Brno | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of Brno — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brno trip today.
Modernist villa by Mies van der Rohe, listed by UNESCO. An essential architecture visit for its groundbreaking open-plan interior.
Brno’s city museum inside Špilberk Castle, covering local history, art, and prison heritage in a dramatic hilltop complex.
Major regional museum with natural science, history, and temporary exhibitions. A strong choice for understanding Moravia in context.
Brno’s main central square, lined with historic facades, events, and public art. A practical meeting point and key place to feel the city.
Historic market square with colorful townhouses, the Parnas fountain, and regular produce and festive markets. One of Brno’s liveliest areas.
Prominent hill around the cathedral, with calm lanes and viewpoints over the old town. Ideal for short walks and classic Brno panoramas.
Brno's classic bun filled with whipped cream. It is a beloved local pastry tied to the city's café culture and everyday sweet eating.
Pork schnitzel with potato salad is a Czech staple widely loved in Brno for family meals, pubs, and festive gatherings.
Roast beef in creamy root vegetable sauce with bread dumplings. A cornerstone Czech dish commonly served in traditional Brno restaurants.
Fine dining restaurant with modern Czech and Central European tasting menus in an elegant, contemporary setting.
Well-known restaurant and wine bar focused on Moravian ingredients, seasonal cooking, and a polished but relaxed atmosphere.
Traditional Brno restaurant by Špilberk Castle known for Czech dishes, local beer, and a historic cellar atmosphere.
More affordable than Prague and many Western European cities. Dining and transit are low-cost, while central hotels are moderate in peak periods.
Service is often not included. Round up or tip 5-10% in restaurants. Round up small taxi fares and leave small change in cafes if service is good.
Official public transport app
Brno, Benešova - Grandhotel (Hlavní nádraží) -> Náměstí Svobody, Brno
Find answers to the most common questions about traveling from Karlovy Vary to Brno by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brno, this guide helps you travel smarter and with confidence.

Most Karlovy Vary to Brno buses use the Karlovy Vary, Dolní Nádraží to Brno, Benešova - Grandhotel (Hlavní nádraží) station pair. Use this guide to compare Karlovy Vary and Brno bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Karlovy Vary, Dolní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Dolní (in the station), Fast Food Express (in the station), Coffee Corner (in the station).
Free Wi-Fi. ATMs are located near the entrance.
Ticket office support is available at Karlovy Vary, Dolní Nádraží.
Available at Karlovy Vary, Dolní Nádraží: Parking, WC.
Accessibility facilities are available at Karlovy Vary, Dolní Nádraží: Elevators, ramps.
Brno, Benešova - Grandhotel (Hlavní nádraží) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located inside the station.
Ticket office support is available at Brno, Benešova - Grandhotel (Hlavní nádraží).
Available at Brno, Benešova - Grandhotel (Hlavní nádraží): Parking, Taxis, WC.
Accessibility facilities are available at Brno, Benešova - Grandhotel (Hlavní nádraží): Elevators, ramps.
Here are some other resources that might have the information you need