The cheapest and fastest buses from Karlovy Vary to Brno
Cheapest price
$7
Average price
$10
Fastest journey
5 h 10 m
Average duration
6 h 15 m
Buses per day
3
Distance
292 km
The best way to find a cheap bus ticket from Karlovy Vary to Brno is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Karlovy Vary to Brno will cost around $10 if you buy it on the day, but the cheapest tickets can be found for only $7.
Of the 3 buses that leave Karlovy Vary for Brno on Sat, Mar 21, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Mar 21 the direct buses cover the 292 km distance in an average of 6 h 15 m but if you time it right, some buses will get you there in just 5 h 10 m .
On Sat, Mar 21 the slowest buses will take 7 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Travel Information
Compare bus and train for Karlovy Vary to Brno
Omio recommends booking the bus as it is the most popular option from Karlovy Vary to Brno among Omio's users. If you are prioritising price take the bus with prices starting from $5. For those with little time consider booking a train which can get you there in 4h 46m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.3kg. The ticket price range depends on the travel mode: a bus costs an average of $5, and a train costs an average of $25.
Distance: 181 miles (292 km)
Compare bus with
Most popular Bus | Train |
|---|---|
$11 Average price Cheapest | $32 Average price |
5h 31m Average total duration 5h 1m Onboard + 30m Additional time* | 5h 16m Average total duration Fastest 4h 46m Onboard + 30m Additional time* |
0.3 - 0.7kg CO2 emissions | 0.1 - 0.3kg CO2 emissions Lowest |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Karlovy Vary to Brno Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:55AM | Arrival Time 12:10PM | Duration 6h15 | Departure days Sun | Cheapest price $19 |
Operator Regiojet | Departure Time 06:00AM | Arrival Time 12:00PM | Duration 6h00 | Departure days Sun | Cheapest price $23 |
Operator FlixBus | Departure Time 06:15AM | Arrival Time 12:10PM | Duration 5h55 | Departure days Sun | Cheapest price $23 |
Operator Regiojet | Departure Time 07:00AM | Arrival Time 12:55PM | Duration 5h55 | Departure days Sun | Cheapest price $26 |
Operator Regiojet | Departure Time 08:00AM | Arrival Time 01:30PM | Duration 5h30 | Departure days Sun | Cheapest price $33 |
Operator FlixBus | Departure Time 09:30AM | Arrival Time 04:30PM | Duration 7h00 | Departure days Sun | Cheapest price $29 |
Operator Regiojet | Departure Time 10:00AM | Arrival Time 03:55PM | Duration 5h55 | Departure days Sun | Cheapest price $33 |
Operator Regiojet | Departure Time 11:00AM | Arrival Time 04:55PM | Duration 5h55 | Departure days Sun | Cheapest price $33 |
Operator FlixBus | Departure Time 11:30AM | Arrival Time 06:05PM | Duration 6h35 | Departure days Sun | Cheapest price $32 |
Operator FlixBus | Departure Time 12:30PM | Arrival Time 07:25PM | Duration 6h55 | Departure days Sun | Cheapest price $41 |
Operator Regiojet | Departure Time 01:00PM | Arrival Time 06:55PM | Duration 5h55 | Departure days Sun | Cheapest price $33 |
Operator Regiojet | Departure Time 02:00PM | Arrival Time 07:55PM | Duration 5h55 | Departure days Sun | Cheapest price $35 |
Operator Regiojet | Departure Time 04:00PM | Arrival Time 09:55PM | Duration 5h55 | Departure days Sun | Cheapest price $35 |
Operator FlixBus | Departure Time 04:10PM | Arrival Time 09:00PM | Duration 4h50 | Departure days Sun | Cheapest price $19 |
Operator Regiojet | Departure Time 05:00PM | Arrival Time 10:55PM | Duration 5h55 | Departure days Sun | Cheapest price $31 |
Operator Regiojet | Departure Time 08:00PM | Arrival Time 09:30AM | Duration 13h30 | Departure days Sun | Cheapest price $28 |
Live departures
Karlovy Vary to Brno bus times
The table below shows live departures for Karlovy Vary to Brno buses for today, Friday, March 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:30 PM Karlovy Vary | 6h35 | 12:05 AM Brno | 0 transfersDirect | |
![]() | 7:30 PM Karlovy Vary | 5h25 | 12:55 AM Brno | 0 transfersDirect | |
| Saturday, March 21 | |||||
![]() | 8:30 AM Karlovy Vary | 7h00 | 3:30 PM Brno | 0 transfersDirect | |
![]() | 10:30 AM Karlovy Vary | 5h10 | 3:40 PM Brno | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Karlovy Vary to Brno by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 21
Mar 22
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Why should you book Karlovy Vary to Brno buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and train to ensure you get the best deal for traveling from Karlovy Vary to Brno.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Karlovy Vary to Brno.
Journey information
Overview: Bus from Karlovy Vary to Brno
Buses from Karlovy Vary to Brno run on average 17 times per day, taking around 5h 1m. Cheap bus tickets for this journey start at $5 (€4) if you book in advance.
There are 1 buses per day. The earliest bus runs at 03:15, the last at 21:20. The fastest bus covers the 181 miles (292 km) distance in 5h 10m.
Distance 181 miles (292 km) |
Average bus duration 5h 1m |
Cheapest ticket price $5 (€4) |
Buses per day 17 |
Direct buses 1 |
Fastest bus 5h 10m |
First bus 03:15 |
Last bus 21:20 |
Bus providers: FlixBus from Karlovy Vary to BrnoYou can travel by bus between Karlovy Vary to Brno with FlixBus for as low as $5 (€4). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Karlovy Vary to Brno
Find answers to the most common questions about traveling from Karlovy Vary to Brno by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brno, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Špilberk Castle, a historic fortress offering panoramic views of the city and housing a museum
- Cathedral of St. Peter and Paul, a striking Gothic cathedral known for its twin spires and rich history
- Villa Tugendhat, a UNESCO World Heritage site showcasing modernist architecture by Mies van der Rohe
- Brno Underground, a network of historical tunnels and cellars beneath the city center
- Moravian Museum, the second-largest museum in the Czech Republic, featuring diverse exhibits on natural history and culture.
- Moravian Karst, a natural reserve with stunning caves and hiking trails located just outside the city
- Brno Technical Museum, an interactive museum featuring exhibits on the history of technology and industry in the region
- Mendel Museum, dedicated to the life and work of Gregor Mendel, the father of genetics
- Lužánky Park, the oldest public park in Brno, perfect for a leisurely stroll or a picnic
- Brno Zoo, offering a fun and educational experience with a variety of animal species.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Karlovy Vary to Brno
- 05:00-23:00
- Free Wi-Fi
- Cafeteria Dolní (in the station)
- Fast Food Express (in the station)
- Coffee Corner (in the station).
- Elevators, ramps
- Available near the waiting area.
- Bus: 1, 2, 3, 4, 6, 10 Train: Regional
- 00:00-23:59
- Free Wi-Fi
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 40, 61, 67 Tram: 1, 2, 4, 8, 9, 10, 12 Train: S2, S3, S6
Most popular bus connections from Karlovy Vary
More options for your journey from Karlovy Vary to Brno
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