- Must visit
Science and Industry Museum
Leading museum of science, industry, transport, and computing on a historic railway site. Essential for understanding Manchester's global impact.
The best way to find a cheap bus ticket from High Wycombe to Manchester is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from High Wycombe to Manchester will cost around €62 if you buy it on the day, but the cheapest tickets can be found for only €52.
It's difficult to get from High Wycombe to Manchester without transferring at least 2 times.
TALGW · NX210 · NX541
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TALHR · NX210 · NX120
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TALHR · NX210 · NX181
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TALGW · NX410 · NX541
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TALHR · NX410 · NX541
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TALGW · NX410 · NX541
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TALGW · NX210 · NX121
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TALGW · NX210 · NX541
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TALHR · NX410 · NX541
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TALHR · NX210 · NX181
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Buses from High Wycombe to Manchester run on average 12 times per day, taking around 5h 28m. Cheap bus tickets for this journey start at €38 but you can travel from only €37 by train.
The earliest bus runs at 00:05, the last at 23:55. The fastest bus covers the 142 miles (229 km) distance in 4h 47m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from High Wycombe to Manchester.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator National Express | Departure Time 06:23AM | Arrival Time 01:30PM | Duration 7h07 | Departure days Tue, Wed, Thu, Fri | Cheapest price €52 |
Operator National Express | Departure Time 07:23AM | Arrival Time 02:20PM | Duration 6h57 | Departure days Tue, Wed, Thu, Fri | Cheapest price €65 |
Operator National Express | Departure Time 09:28AM | Arrival Time 04:25PM | Duration 6h57 | Departure days Tue, Wed, Fri, Sat | Cheapest price €67 |
Operator National Express | Departure Time 09:48AM | Arrival Time 05:40PM | Duration 7h52 | Departure days Mon, Thu | Cheapest price €43 |
Operator National Express | Departure Time 10:48AM | Arrival Time 06:35PM | Duration 7h47 | Departure days Tue, Wed, Fri | Cheapest price €63 |
Operator National Express | Departure Time 11:28AM | Arrival Time 07:40PM | Duration 8h12 | Departure days Tue, Wed, Fri | Cheapest price €63 |
Operator National Express | Departure Time 11:48AM | Arrival Time 07:05PM | Duration 7h17 | Departure days Sat | Cheapest price €56 |
Operator National Express | Departure Time 12:48PM | Arrival Time 08:15PM | Duration 7h27 | Departure days Tue, Wed, Fri | Cheapest price €63 |
Operator National Express | Departure Time 01:48PM | Arrival Time 08:35PM | Duration 6h47 | Departure days Mon | Cheapest price €71 |
Operator National Express | Departure Time 02:28PM | Arrival Time 09:40PM | Duration 7h12 | Departure days Sat, Sun | Cheapest price €74 |
Operator National Express | Departure Time 02:33PM | Arrival Time 09:55PM | Duration 7h22 | Departure days Mon | Cheapest price €61 |
Operator National Express | Departure Time 02:48PM | Arrival Time 09:45PM | Duration 6h57 | Departure days Tue, Wed, Fri | Cheapest price €48 |
Operator National Express | Departure Time 03:13PM | Arrival Time 10:10PM | Duration 6h57 | Departure days Sat | Cheapest price €60 |
Operator National Express | Departure Time 03:48PM | Arrival Time 10:45PM | Duration 6h57 | Departure days Tue, Wed, Fri | Cheapest price €51 |
Operator National Express | Departure Time 05:28PM | Arrival Time 12:25AM | Duration 6h57 | Departure days Tue, Wed | Cheapest price €52 |
Operator National Express | Departure Time 06:20PM | Arrival Time 12:25AM | Duration 6h05 | Departure days Tue, Wed, Fri | Cheapest price €48 |
Operator National Express | Departure Time 07:28PM | Arrival Time 01:40AM | Duration 6h12 | Departure days Tue, Wed, Fri | Cheapest price €52 |
Operator National Express | Departure Time 09:03PM | Arrival Time 05:05AM | Duration 8h02 | Departure days Mon | Cheapest price €60 |
Operator National Express | Departure Time 10:03PM | Arrival Time 06:05AM | Duration 8h02 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price €53 |
Operator National Express | Departure Time 10:43PM | Arrival Time 06:15AM | Duration 7h32 | Departure days Tue, Wed, Fri | Cheapest price €62 |
The table below shows live departures for High Wycombe to Manchester buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:03 PM High Wycombe | 8h02 | 5:05 AM Manchester | 0 transfersDirect | |
![]() | 10:03 PM High Wycombe | 8h02 | 6:05 AM Manchester | 0 transfersDirect | |
| Tuesday, November 3 | |||||
TALGW · NX210 · NX121 | 6:23 AM High Wycombe, Coachway Handy Cross | 6h37 | 1:00 PM Manchester, Coach Station | 2 transfers | |
TALGW · NX210 · NX590 | 7:23 AM High Wycombe, Coachway Handy Cross | 7h57 | 3:20 PM Manchester, Coach Station | 2 transfers | |
TALGW · NX210 · NX541 | 9:28 AM High Wycombe, Coachway Handy Cross | 6h37 | 4:05 PM Manchester, Coach Station | 2 transfers | |
TALHR · NX409 · NX541 | 10:48 AM High Wycombe, Coachway Handy Cross | 6h57 | 5:45 PM Manchester, Coach Station | 2 transfers | |
TALGW · NX210 · NX541 | 11:28 AM High Wycombe, Coachway Handy Cross | 8h02 | 7:30 PM Manchester, Coach Station | 2 transfers | |
TALHR · NX210 · NX120 | 12:48 PM High Wycombe, Coachway Handy Cross | 7h27 | 8:15 PM Manchester, Coach Station | 2 transfers | |
TALHR · NX410 · NX541 | 2:48 PM High Wycombe, Coachway Handy Cross | 6h47 | 9:35 PM Manchester, Coach Station | 2 transfers | |
TALHR · NX210 · NX120 | 3:48 PM High Wycombe, Coachway Handy Cross | 7h07 | 10:55 PM Manchester, Coach Station | 2 transfers | |
TALGW · NX210 · NX541 | 5:28 PM High Wycombe, Coachway Handy Cross | 6h57 | 12:25 AM Manchester, Coach Station | 2 transfers | |
TALHR · NX210 · NX181 | 6:20 PM High Wycombe, Coachway Handy Cross | 6h55 | 1:15 AM Manchester, Coach Station | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from High Wycombe to Manchester with National Express. Overnight buses available on this route with National Express. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Manchester — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Manchester trip today.
Leading museum of science, industry, transport, and computing on a historic railway site. Essential for understanding Manchester's global impact.
Major art museum with Pre-Raphaelite works, design, and changing exhibitions. A central cultural stop with broad appeal.
The University of Manchester museum spans dinosaurs, Egypt, nature, and anthropology. Recently renewed and excellent for varied interests.
Historic canal-side district with Roman remains, warehouses, and walkable towpaths. One of Manchester's most atmospheric urban areas.
Central square framed by grand civic buildings, museums, and monuments. A classic starting point for exploring the city centre.
Creative quarter of street art, music history, indie shops, and nightlife. It is one of Manchester's most characterful neighborhoods.
A flaky pastry pie filled with spiced potatoes, onion and often chickpeas. Created by Manchester’s South Asian community and now a city staple.
A comforting Northern pudding of suet pastry filled with beef and onion, traditionally steamed and served with gravy. Common in Greater Manchester pubs.
Manchester’s classic order of battered fish with chips, often served with mushy peas and curry sauce. A long-standing local takeaway favourite.
Iconic market bakery and café known for Manchester tarts, Eccles cakes and hearty lunches. Casual, busy and deeply rooted in local food culture.
Refined modern British fine dining in a restored townhouse. Known for tasting menus, polished service and one of Manchester’s top culinary reputations.
Lively Indian restaurant famous for bold curries, grills and chaat. A long-established Rusholme favourite with a casual, energetic atmosphere.
Moderate for the UK: hotels often cost less than London, while dining and transit are manageable for tourists with many mid-range options.
Service may be included. If not, 10-12.5% in restaurants is common for good service. Round up or add a little for taxis. Cafe tipping is optional.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Manchester.
Find answers to the most common questions about traveling from High Wycombe to Manchester by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Manchester, this guide helps you travel smarter and with confidence.

Most High Wycombe to Manchester buses use the High Wycombe, Coachway Handy Cross to Manchester, Coach Station station pair, with some services arriving at Manchester, Airport. Use this guide to compare High Wycombe and Manchester bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
High Wycombe, Coachway Handy Cross is 1 km from High Wycombe city centre. Public transport options include:
High Wycombe, Coachway Handy Cross has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at High Wycombe, Coachway Handy Cross. ATMs are available at High Wycombe, Coachway Handy Cross.
Ticket office support is available at High Wycombe, Coachway Handy Cross.
Available at High Wycombe, Coachway Handy Cross: Parking, Taxis, WC.
Accessibility facilities are available at High Wycombe, Coachway Handy Cross: Accessible for passengers with reduced mobility.
Manchester, Coach Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café at the Station (in the station), Fast Food Express (in the station).
Free Wi-Fi. ATMs are located within the station for cash withdrawals.
Ticket office support is available at Manchester, Coach Station.
Available at Manchester, Coach Station: Parking, Taxis, WC.
Accessibility facilities are available at Manchester, Coach Station: Ramps, assistance.
Manchester, Shudehill Interchange has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Manchester, Shudehill Interchange.
Available at Manchester, Shudehill Interchange: Parking, Taxis, WC.
Accessibility facilities are available at Manchester, Shudehill Interchange: Elevators, ramps.
Manchester, Princess Road / Moss Lane East is 2 km from Manchester city centre. Public transport options include:
Manchester, Princess Road / Moss Lane East has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Manchester, Princess Road / Moss Lane East. ATMs are available at Manchester, Princess Road / Moss Lane East.
Ticket office support is available at Manchester, Princess Road / Moss Lane East.
Available at Manchester, Princess Road / Moss Lane East: Parking, Taxis, WC.
Accessibility facilities are available at Manchester, Princess Road / Moss Lane East: Accessible for wheelchairs.
Check bus stations information for High Wycombe and Manchester, including where buses depart and arrive on this route.