- Must visit
COSI
A major science museum with hands-on exhibits, a planetarium, and family-friendly programs that make science engaging for all ages.
Take a bus from Anderson, SC to Columbus, OH and enjoy the approximately 377 miles (608 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 00:50, the last at 22:05.
Distance 377 miles (608 km) |
Buses per day 6 |
First bus 12:50 AM |
Last bus 10:05 PM |
Cheapest Month Aug |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Jul - Sep |
Discover the best of Columbus, OH — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Columbus, OH trip today.
A major science museum with hands-on exhibits, a planetarium, and family-friendly programs that make science engaging for all ages.
This leading art museum offers strong American and European collections, special exhibitions, and a notable sculpture garden.
Located on Ohio State's campus, this museum presents contemporary art and rotating exhibitions in an acclaimed modern building.
Columbus's best-known historic district has brick streets, restored homes, and a walkable atmosphere ideal for architecture lovers.
A scenic downtown riverfront park with fountains, trails, and skyline views, popular for walks, events, and photos.
This large botanical park is famous for seasonal displays, glasshouses, and the iconic Chihuly installation in the conservatory.
A tangy, tomato-based slaw served on hot dogs or sandwiches. It is a long-running Columbus comfort food linked to old local chili and diner culture.
A sweet, cinnamon-forward fried pastry sold at the Ohio State Fair since the early 1900s. It is one of central Ohio's most iconic fair treats.
A shredded chicken and cracker casserole common at Columbus-area potlucks and game days. It is a nostalgic Midwestern comfort dish in central Ohio.
Refined tasting-menu restaurant in the Short North with inventive seasonal cooking and one of the city's strongest fine dining reputations.
Acclaimed local brewery and gastropub serving creative beers and polished comfort food in a stylish but relaxed setting.
Beloved local pizzeria known for thin crust, square-cut Columbus-style pies in a casual neighborhood setting.
Moderate for a U.S. city: hotels, dining, and transit usually cost less than New York or Chicago, but more than smaller Midwest towns.
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or coffee at cafes if service is provided.
Find answers to the most common questions about traveling from Anderson, SC to Columbus, OH by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Columbus, OH, this guide helps you travel smarter and with confidence.

Most Anderson, SC to Columbus, OH buses use the Anderson, Highway 81 S (Greyhound Bus Station) to Columbus, E Mound St (Akili Christian High School) station pair, with some services arriving at Columbus, E Town St (Bus Station). Use this guide to compare Anderson, SC and Columbus, OH bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Anderson, Highway 81 S (Greyhound Bus Station) is 14 km from Anderson city centre. Public transport options include:
Anderson, Highway 81 S (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi in waiting area. ATMs are available at Anderson, Highway 81 S (Greyhound Bus Station).
Ticket office support is available at Anderson, Highway 81 S (Greyhound Bus Station).
Available at Anderson, Highway 81 S (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Anderson, Highway 81 S (Greyhound Bus Station): Wheelchair accessible entrance and seating.
Columbus, E Mound St (Akili Christian High School) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Columbus, E Mound St (Akili Christian High School). ATMs are available at Columbus, E Mound St (Akili Christian High School).
Ticket office support is available at Columbus, E Mound St (Akili Christian High School).
Available at Columbus, E Mound St (Akili Christian High School): Parking, Taxis, WC.
Accessibility facilities are available at Columbus, E Mound St (Akili Christian High School): Wheelchair accessible buses available.
Columbus, E Town St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Columbus, E Town St (Bus Station). ATMs are available at Columbus, E Town St (Bus Station).
Ticket office support is available at Columbus, E Town St (Bus Station).
Available at Columbus, E Town St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Columbus, E Town St (Bus Station): Wheelchair accessible bus platforms.
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