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Getting from Venice to Salzburg is simple, but travelers need to be aware that however they choose to travel, at least one change will be needed. The fastest route is probably by air. You can fly straight to Munich and then catch a train or bus to Salzburg, and be there in around 4 hours. Otherwise, trains take at least 6 hours 30 minutes, and buses much longer.
Return trips from Salzburg to Venice are also available.
The best way to travel from Venice to Salzburg by bus is by taking a Flixbus service to Verona and then changing onto a Student Agency service to Salzburg. However, be aware that there are only two buses every week from Verona to Salzburg - one on Tuesday and one on Saturday. Both leave at 6:15 p.m. and take 6 hours to reach Salzburg. This means that, in total, the journey from Venice takes between 9 and 12 hours.
No direct trains are available from Venice to Salzburg, but you can catch an OBB Intercity bus from Venice to Villach, and an OBB train from there to Salzburg. Buses run every day from Venice's Tronchetto, Maestre and Santa Lucia bus-stops and take 3 hours 30 minutes. The train from Villach to Salzburg takes 2 hours 30 minutes and trains depart every 2 hours throughout the day.
There are no direct flights between Venice and Salzburg's major airport, but you can fly from Marco Polo Airport directly into nearby Munich Airport, a short distance across the German border. Transavia and Air Dolomiti provide daily connections (but check seasonal schedules as they may offer a restricted service during the winter). Getting from Munich to Salzburg adds two hours onto the journey, resulting in a total journey time of 4 hours, which rises to around 6 hours when travel to Venice Marco Polo airport is included.