Taking the bus is the cheapest way to travel from Paris to Milan. Buses traveling from Paris to Milan depart from either Paris' Porte Maillot, Gare Routière Galliéni, or Quai de Bercy bus station and take at least 12 and a half hours to arrive at Milan's Lampugnano bus station. At least 4 buses travel from Paris to Milan every day. All buses travel from Paris to Milan overnight. Bus companies that travel from Paris to Milan include Baltour, Ouibus, and Eurolines.

Taking a flight is the fastest way to travel from Paris to Milan. Flights depart from either Paris' Charles de Gaulle or Orly airport and arrive at either Milan's Linate or Malpensa airport after 1:25 h of flight time. Taking a flight from Paris to Milan is significantly faster than taking the train or bus even when traveling to and from Paris and Milan's airports is taken into consideration. Airlines that travel directly from Paris to Milan include EasyJet, Air France, and Alitalia.

Taking a flight is by far the most popular way to travel from Paris to Milan. Taking a flight, even when traveling to and from Paris and Milan's airports is considered, is at least 2 and a half hours faster than traveling from Paris to Milan by train and at least 8 hours faster than taking the bus. At least 25 flights travel directly from Paris to Milan every day, which are usually cheaper than buying a train ticket.