Compare prices and tickets Mendrisio to Domodossola by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Mendrisio to Domodossola trains with Omio?
Swiss Railways (SBB/CFF/FFS) operates all train services from Mendrisio to Domodossola. Omio is the only official third party seller for Swiss Railways (SBB/CFF/FFS) tickets.
Why book with Omio vs Swiss Railways (SBB/CFF/FFS)?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Swiss Railways (SBB/CFF/FFS) with all available travel options, which are train and bus to ensure you get the best deal for traveling from Mendrisio to Domodossola.
Why book with Omio over Trainline and Rail Europe?
- Official reseller: Swiss Railways (SBB/CFF/FFS) tickets can only be bought on Omio or Swiss Railways (SBB/CFF/FFS)'s website as Omio is the only official third party seller for Swiss Railways (SBB/CFF/FFS) tickets. Trainline, RailEurope, and Rail.Ninja do not sell Swiss Railways (SBB/CFF/FFS) tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Mendrisio to Domodossola.
Journey information
Overview: Train from Mendrisio to Domodossola
Trains from Mendrisio to Domodossola run on average 4 times per day, taking around 3h 5m. Cheap train tickets for this journey start at $47 (€38) if you book in advance.
The earliest train runs at 04:56, the last at 20:07. The fastest train covers the 37 miles (60 km) distance in 2h 47m.
Distance 37 miles (60 km) |
Average train duration 3h 5m |
Cheapest ticket price $47 (€38) |
Trains per day 4 |
Fastest train 2h 47m |
First train 04:56 |
Last train 20:07 |
Train companies: Swiss Railways (SBB/CFF/FFS) from Mendrisio to Domodossola trainsSwiss Railways (SBB/CFF/FFS) trains will get you between Mendrisio and Domodossola from $47 (€38). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Swiss Railways (SBB/CFF/FFS)
FAQs: Trains from Mendrisio to Domodossola
Find answers to the most common questions about traveling from Mendrisio to Domodossola by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Domodossola, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Mendrisio to Domodossola
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- Parking is available 24/7 in the nearby parking lot.
- Ristorante Pizzeria Corona
- Osteria Lanterna
- Outside the main entrance.
- Ramps, restrooms.
- CHF 1
- Hotel Coronado
- Albergo Stazione Mendrisio
- Hotel Milano
- Located in the main hall
- 200 places, covered
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-3 for trains to Italy and regional destinations
- Train: S10, S40
- Bus: Several lines available
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- The car park is open 7 days a week, accessible from the main entrance.
- Ristorante La Meridiana
- Osteria Vecchio Borgo
- Outside the main entrance.
- Elevators, ramps.
- €1
- Hotel Corona
- Hotel Ristorante Eurossola
- Hotel Domodossola
- Located in the main hall
- Avis
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-5 for trains to Switzerland and regional destinations
- Train: Regional and Eurocity trains
- Bus: Several local lines available
Most popular train connections from Mendrisio
More options for your journey from Mendrisio to Domodossola
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