- Must visit
Greenville County Museum of Art
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
Flights from Pittsburgh, PA to Greenville, SC depart on average 53 times per day, taking around 6h 36m. Cheap flight tickets for this journey start at $379 (€310) but you can travel from only $197 (€161) by bus.
The earliest flight runs at 05:00, the last at 20:21. The fastest flight covers the 407 miles (656 km) distance in 6h 36m. March is the cheapest month to fly.
Distance 407 miles (656 km) |
Average flight duration 6h 36m |
Cheapest ticket price $379 (€310) |
Flights per day 53 |
Fastest flight 6h 36m |
First flight 5:00 AM |
Last flight 8:21 PM |
Cheapest Month Mar |
Cheapest Day Tue |
High Season Jan - Mar |
Low Season Oct - Dec |
Omio recommends booking the bus as it is the most popular option from Pittsburgh, PA to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $197. For those with little time consider booking a flight which can get you there in 6h 36m. The ticket price range depends on the travel mode: a bus costs an average of $197, and a flight costs an average of $379.
Distance: 407 miles (656 km)
| Flight | Most popular Bus | Train |
|---|---|---|
$379 Average price | $197 Average price Cheapest | $261 Average price |
9h 36m Average total duration Fastest 6h 36m Onboard + 3h 0m Additional time* | 24h 35m Average total duration 24h 5m Onboard + 30m Additional time* | 24h 29m Average total duration 23h 59m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Pittsburgh, PA to Greenville, SC:
A bus is $64 (€52) less than a train for this route with tickets for a train from Pittsburgh, PA to Greenville, SC costing on average $261 (€214).
A bus is $181 (€148) less than a flight for this route with tickets for a flight from Pittsburgh, PA to Greenville, SC costing on average $379 (€310).
Other travel options to Greenville, SC take longer:
Train takes on average 23h 59m.
Bus takes on average 24h 5m.
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
Regional history museum with permanent and rotating exhibits on the people and stories of Upstate South Carolina. A strong choice for understanding Greenville’s local context.
Specialized museum displaying rare historic instruments from around the world. A distinctive local favorite for music, design, and cultural history.
Greenville’s central downtown street lined with shops, public art, plazas, and event spaces. It is the main place to walk and experience the city atmosphere.
Downtown park built around waterfalls, gardens, and river overlooks. It is Greenville’s signature public space and a top stop for first-time visitors.
Popular multi-use greenway for walking and cycling, linking Greenville with nearby communities. Widely loved by locals and visitors for active sightseeing.
Slow-smoked pork, often chopped or pulled, served with the state's signature mustard-based sauce. It is a defining Upstate and South Carolina tradition.
Slices of unripe tomato coated and fried until crisp, often served with remoulade or pimento cheese. A classic Southern starter common in Greenville restaurants.
Creamy stone-ground grits topped with shrimp, gravy, or bacon. This Lowcountry favorite is widely loved in Greenville as part of broader South Carolina cuisine.
Well-regarded neighborhood restaurant focused on seasonal Southern-influenced American cooking with a polished but relaxed atmosphere.
A long-running downtown Greenville favorite serving refined Southern cuisine in a lively, upscale setting. Known for shrimp and grits, brunch, and strong wine selections.
Popular casual spot for barbecue, ribs, and Southern comfort food near Falls Park. Lively atmosphere and a good place to try local smoked meats.
Moderate by U.S. standards: casual dining is affordable, while upscale downtown hotels and restaurants cost more.
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff a few dollars, and round up for coffee only if desired.
Find answers to the most common questions about traveling from Pittsburgh, PA to Greenville, SC by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

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