- Recommended
Museo delle Sinopie
Museum displaying the original preparatory drawings for the Camposanto frescoes, an important insight into medieval artistic techniques in Pisa.
Cheapest price
$16
Average price
$20
Fastest journey
4 h 35 m
Average duration
5 h 11 m
Buses per day
5
Distance
262 km
The best way to find a cheap bus ticket from Vatican to Pisa is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Vatican to Pisa will cost around $20 if you buy it on the day, but the cheapest tickets can be found for only $16.
Of the 5 buses that leave Vatican for Pisa on Sun, Jun 21, 5 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct buses cover the 262 km distance in an average of 5 h 11 m but if you time it right, some buses will get you there in just 4 h 35 m .
On Sun, Jun 21 the slowest buses will take 5 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Omio recommends booking the train as it is the most popular option from Vatican to Pisa among Omio's users. If you are prioritising price take the bus with prices starting from $14. For those with little time consider booking a train which can get you there in 3h 6m. The ticket price range depends on the travel mode: a bus costs an average of $14, and a train costs an average of $20.
Distance: 162 miles (262 km)
| Bus | Most popular Train | Driving |
|---|---|---|
$19 Average price Cheapest | $29 Average price | $82 Average price (fuel + tolls) |
6h 1m Average total duration 5h 31m Onboard + 30m Additional time* | 3h 36m Average total duration Fastest 3h 6m Onboard + 30m Additional time* | 3h 46m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Vatican to Pisa:
A bus is $10 (€8) less than a train for this route with tickets for a train from Vatican to Pisa costing on average $29 (€24).
Other travel options to Pisa take longer:
Bus takes on average 5h 31m.
Tickets start at around $19 (€16) compared to roughly $82 (€67) in fuel and tolls — a saving of about $63 (€51). The journey takes 5h 31m versus 3h 46m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, Marino Autolinee.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 06:20AM | Arrival Time 11:35AM | Duration 5h15 | Departure days Mon | Cheapest price $21 |
Operator FlixBus | Departure Time 06:30AM | Arrival Time 11:45AM | Duration 5h15 | Departure days Mon | Cheapest price $21 |
Operator FlixBus | Departure Time 06:55AM | Arrival Time 12:30PM | Duration 5h35 | Departure days Wed | Cheapest price $15 |
Operator FlixBus | Departure Time 07:30AM | Arrival Time 12:45PM | Duration 5h15 | Departure days Thu, Fri, Sun | Cheapest price $15 |
Operator FlixBus | Departure Time 09:25AM | Arrival Time 02:40PM | Duration 5h15 | Departure days Mon | Cheapest price $17 |
Operator FlixBus | Departure Time 10:50AM | Arrival Time 05:05PM | Duration 6h15 | Departure days Fri | Cheapest price $14 |
Operator Marino Autolinee | Departure Time 11:50AM | Arrival Time 05:35PM | Duration 5h45 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $22 |
Operator Marino Autolinee | Departure Time 12:50PM | Arrival Time 06:35PM | Duration 5h45 | Departure days Mon, Wed, Sun | Cheapest price $22 |
Operator FlixBus | Departure Time 04:50PM | Arrival Time 09:25PM | Duration 4h35 | Departure days Tue, Wed, Sat, Sun | Cheapest price $17 |
Operator FlixBus | Departure Time 05:50PM | Arrival Time 10:25PM | Duration 4h35 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $16 |
Operator FlixBus | Departure Time 09:45PM | Arrival Time 05:20AM | Duration 7h35 | Departure days Fri | Cheapest price $24 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 04:20AM | Duration 4h50 | Departure days Wed | Cheapest price $17 |
The table below shows live departures for Vatican to Pisa buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 4:50 PM Vatican | 4h35 | 9:25 PM Pisa | 0 transfersDirect | |
![]() | 5:50 PM Vatican | 4h35 | 10:25 PM Pisa | 0 transfersDirect | |
| Sunday, June 21 | |||||
![]() | 7:30 AM Vatican | 5h15 | 12:45 PM Pisa | 0 transfersDirect | |
![]() | 11:50 AM Vatican | 5h45 | 5:35 PM Pisa | 0 transfersDirect | |
![]() | 12:50 PM Vatican | 5h45 | 6:35 PM Pisa | 0 transfersDirect | |
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Vatican to Pisa run on average 8 times per day, taking around 5h 31m. Cheap bus tickets for this journey start at $14 (€12) if you book in advance.
There are 5 buses per day. The earliest bus runs at 00:10, the last at 23:52. The fastest bus covers the 162 miles (262 km) distance in 4h 35m.
Distance 162 miles (262 km) |
Average bus duration 5h 31m |
Cheapest ticket price $14 (€12) |
Buses per day 8 |
Direct buses 5 |
Fastest bus 4h 35m |
First bus 12:10 AM |
Last bus 11:52 PM |
Cheapest Month Jun |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Mon |
Least Busy Day Sun |
Best time to book 63 days |
Discover the best of Pisa — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Pisa trip today.
Museum displaying the original preparatory drawings for the Camposanto frescoes, an important insight into medieval artistic techniques in Pisa.
Museum of the Cathedral complex with sculptures, treasures, and artworks connected to Piazza dei Miracoli and its monuments.
Major exhibition venue in central Pisa, known for temporary art shows and a refined collection in a restored historic palace.
Pisa's most celebrated monumental square, home to the Leaning Tower and the city's essential first stop.
The riverside promenades along the Arno offer classic city views, elegant palaces, and one of Pisa's best walking experiences.
Lively historic street ideal for strolling under arcades, shopping, and experiencing the rhythm of central Pisa.
Thin chickpea flour flatbread baked in a wood oven. A classic Tuscan street food widely loved in Pisa for its simple, savory flavor.
A thick Tuscan bread and tomato soup made with garlic, olive oil, and basil. It is a comforting local staple closely tied to regional cucina povera.
Traditional Tuscan vegetable and bread soup, usually made with beans, kale, and day-old bread. It is hearty, rustic, and strongly associated with local home cooking.
Established osteria near the center, known for refined Tuscan cooking, seasonal ingredients, and a more elegant dining experience.
Well-known traditional restaurant in central Pisa, appreciated for Tuscan dishes, seafood, and a warm historic atmosphere.
Established restaurant in Pisa known for reliable Tuscan cuisine, pasta, and an intimate atmosphere suited to a leisurely dinner.
Generally moderate by Italian standards. Budget meals are easy to find, while hotels near major sights and peak-season dining cost more.
Service is often included or covered by a coperto. Tipping is not obligatory; round up or leave EUR 1-5 for good service. Taxis are usually rounded up, and bar tips are minimal.
Official public transport app
Pisa, Via delle Fiamme Gialle (Park Pietrasantina) -> Pisa Centrale
Find answers to the most common questions about traveling from Vatican to Pisa by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Pisa, this guide helps you travel smarter and with confidence.

Most Vatican to Pisa buses use the Roma, Autostazione Tiburtina to Pisa, Via delle Fiamme Gialle (Park Pietrasantina) station pair, with some services arriving at Pisa, Aeroporto Parcheggio Aurelia. Use this guide to compare Vatican and Pisa bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need