- Must visit
California Academy of Sciences
Renowned science museum with rainforest dome, aquarium, and planetarium. Interactive exhibits make it a standout for all ages.
Omio recommends booking the bus as it is the most popular option from Santa Clarita, CA to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from €38. For those with little time consider booking a flight which can get you there in 1h 35m. The ticket price range depends on the travel mode: a bus costs an average of €38, and a flight costs an average of €51.
Distance: 318 miles (513 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
€63 Average price Cheapest | €115 Average price | €69 Average price | €59 Average price (fuel + tolls) |
8h 0m Average total duration 7h 30m Onboard + 30m Additional time* | 4h 35m Average total duration Fastest 1h 35m Onboard + 3h 0m Additional time* | 9h 15m Average total duration 8h 45m Onboard + 30m Additional time* | 5h 20m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Santa Clarita, CA to San Francisco, CA:
A bus is €6 less than a train for this route with tickets for a train from Santa Clarita, CA to San Francisco, CA costing on average €69.
A bus is €52 less than a flight for this route with tickets for a flight from Santa Clarita, CA to San Francisco, CA costing on average €115.
Other travel options to San Francisco, CA take longer:
Bus takes on average 7h 30m.
Train takes on average 8h 45m.
You'll arrive about -3h -10m sooner (7h 30m by bus vs 5h 20m by car) and save roughly €-4.08 compared to fuel and tolls (€63 vs €59). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by Greyhound, FlixBus.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:30AM | Arrival Time 12:35PM | Duration 12h05 | Departure days Fri | Cheapest price €120 |
Operator Greyhound | Departure Time 06:35AM | Arrival Time 02:15PM | Duration 7h40 | Departure days Tue, Sun | Cheapest price €59 |
Operator Greyhound | Departure Time 07:25AM | Arrival Time 07:25PM | Duration 12h00 | Departure days Tue | Cheapest price €65 |
Operator Greyhound | Departure Time 07:35AM | Arrival Time 03:15PM | Duration 7h40 | Departure days Tue | Cheapest price €60 |
Operator Greyhound | Departure Time 08:25AM | Arrival Time 08:25PM | Duration 12h00 | Departure days Sat | Cheapest price €71 |
Operator Greyhound | Departure Time 01:55PM | Arrival Time 10:05PM | Duration 8h10 | Departure days Fri | Cheapest price €80 |
Operator FlixBus | Departure Time 04:30PM | Arrival Time 07:05AM | Duration 14h35 | Departure days Thu | Cheapest price €38 |
Operator FlixBus | Departure Time 04:40PM | Arrival Time 12:35AM | Duration 7h55 | Departure days Tue | Cheapest price €92 |
Operator Greyhound | Departure Time 11:55PM | Arrival Time 07:10AM | Duration 7h15 | Departure days Fri | Cheapest price €109 |
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Santa Clarita, CA to San Francisco, CA run on average 12 times per day, taking around 7h 30m. Cheap bus tickets for this journey start at €38 if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:25, the last at 23:35. The fastest bus covers the 318 miles (513 km) distance in 7h 40m.
Distance 318 miles (513 km) |
Average bus duration 7h 30m |
Cheapest ticket price €38 |
Buses per day 12 |
Direct buses 2 |
Fastest bus 7h 40m |
First bus 12:25 AM |
Last bus 11:35 PM |
Cheapest Month Feb |
Cheapest Day Fri |
High Season Jan - Mar |
Low Season Oct - Dec |
Discover the best of San Francisco, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Francisco, CA trip today.
Renowned science museum with rainforest dome, aquarium, and planetarium. Interactive exhibits make it a standout for all ages.
Major fine arts museum in Golden Gate Park with American art, textiles, and a panoramic tower. A classic cultural highlight.
Leading modern and contemporary art museum with landmark architecture and strong global collections. Essential for art-focused visitors.
Large urban park with gardens, lakes, museums, and trails. It is a must for relaxing, walking, and seeing several major attractions.
Steeply curving block lined with flowers and grand homes. This famous street offers classic photos and a quintessential San Francisco scene.
Popular waterfront promenade with bay views, piers, and ferries. Great for walking, people-watching, and connecting to nearby sights.
A crusty loaf with a tangy flavor shaped by the city’s historic wild yeast culture. It is one of San Francisco’s most iconic foods.
Fresh local Dungeness crab, often cracked and served simply or in cioppino. It is a Bay Area seasonal specialty tied to the fishing waterfront.
A tomato-based seafood stew created by Italian American fishermen in North Beach. It is a classic San Francisco dish built from the day’s catch.
Celebrated fine dining destination known for inventive tasting menus and polished service in an elegant, intimate setting.
Historic North Beach seafood house famous for cioppino, crab, and old-school San Francisco waterfront charm.
Legendary Mission taqueria known for large Mission-style burritos and a lively, no-frills local atmosphere.
Very high hotel, dining, and transport costs make San Francisco pricier than most US cities and many major tourist destinations.
Tip 18-20% at restaurants, 15-20% for taxis, and round up or tip $1 at cafes for good service.
Find answers to the most common questions about traveling from Santa Clarita, CA to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

Most Santa Clarita, CA to San Francisco, CA buses use the San Fernando, Rinaldi St / Rincon Ave (Greyhound Bus Stop) to San Francisco, Transit Center Bay 29 station pair, with some services arriving at San Francisco, Townsend Street / 5th Street. Use this guide to compare Santa Clarita, CA and San Francisco, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
San Francisco, Transit Center Bay 29 is 2 km from San Francisco city centre. Public transport options include:
San Francisco, Transit Center Bay 29 has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at San Francisco, Transit Center Bay 29. ATMs are available at San Francisco, Transit Center Bay 29.
Ticket office support is available at San Francisco, Transit Center Bay 29.
Available at San Francisco, Transit Center Bay 29: Parking, Taxis, WC.
Accessibility facilities are available at San Francisco, Transit Center Bay 29: Wheelchair accessible areas present.
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