- Must visit
Tampa Museum of Art
Major art museum on the Riverwalk with Greek and Roman antiquities, modern art, and a strong photography collection.
Cheapest price on Oct 21
$107
Average ticket price on Oct 21
$111
Fastest journey on Oct 21
18 h 25 m
Average journey duration on Oct 21
1 d 1 h 23 m
Buses on Oct 21
3
Distance
724 km
The best way to find a cheap bus ticket from Myrtle Beach, SC to Tampa, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Myrtle Beach, SC to Tampa, FL will cost around $111 if you buy it on the day, but the cheapest tickets can be found for only $107.
It's difficult to get from Myrtle Beach, SC to Tampa, FL without transferring at least once.
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FlixBus
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FlixBus · FlixBus
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FlixBus · FlixBusBuses from Myrtle Beach, SC to Tampa, FL run on average 2 times per day, taking around 17h 34m. Cheap bus tickets for this journey start at $74 if you book in advance.
The earliest bus runs at 06:10, the last at 22:35. The fastest bus covers the 449 miles (724 km) distance in 11h 0m.
Distance 449 miles (724 km) |
Average bus duration 17h 34m |
Cheapest ticket price $74 |
Buses per day 2 |
Fastest bus 11h 0m |
First bus 6:10 AM |
Last bus 10:35 PM |
Cheapest Month Sep |
Cheapest Day Tue |
Best time to book 14 days |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:40PM | Arrival Time 06:40AM | Duration 18h00 | Departure days Everyday | Cheapest price $85 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 10:25PM | Duration 33h40 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $93 |
The table below shows live departures for Myrtle Beach, SC to Tampa, FL buses for today, Tuesday, October 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
+ FlixBus | 12:40 PM Myrtle Beach, N Oak St (Bus Station) | 18h25 | 7:05 AM Tampa, Marion Transit Center | 1 transfer | |
+ FlixBus · FlixBus | 12:40 PM Myrtle Beach, N Oak St (Bus Station) | 24h05 | 12:45 PM Tampa, USF Holly Drive (Central Plant), FL | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of Tampa, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Tampa, FL trip today.
Major art museum on the Riverwalk with Greek and Roman antiquities, modern art, and a strong photography collection.
Engaging family-friendly museum exploring Tampa Bay history through exhibits on pirates, cigars, industry, and local communities.
Fascinating history museum inside the former Tampa Bay Hotel, showcasing Gilded Age rooms, décor, and Florida tourism heritage.
Scenic waterfront promenade linking parks, museums, and downtown landmarks; ideal for walking, biking, and skyline views.
Tampa's most historic district, known for brick streets, cigar heritage, nightlife, and a distinctive Cuban and immigrant legacy.
Popular bayside path and green space on Davis Islands with sweeping water views, downtown panoramas, and sunset appeal.
A Cuban sandwich layered with roast pork, ham, salami, Swiss cheese, pickles, and mustard on pressed Cuban bread. Tampa's version is a defining local classic.
Deviled crab is a Tampa staple: seasoned blue crab mixed with Cuban bread crumbs, shaped into a shell-like croquette, then breaded and fried.
A chilled espresso drink sweetened and shaken until frothy. Popular in Tampa's Cuban communities, it is a local coffee ritual and social pick-me-up.
Beloved Tampa institution known for deviled crab, Cuban sandwiches, and casual old-Tampa counter service.
Upscale modern Spanish restaurant in historic Ybor, known for refined tapas, cocktails, and a polished dining room.
Historic Ybor City restaurant famed for the original Tampa Cuban sandwich and old-school Spanish-Cuban atmosphere.
Moderate for U.S. beach cities: hotels can be high in peak season, but dining and local transport are usually manageable for most visitors.
Tip 15-20% at restaurants, 18-22% for great service. Taxis usually 10-15%. For cafes, small change or $1 per drink is common but optional.
Official public transport app
Tampa International Airport -> Downtown Tampa, Tampa, FL
Find answers to the most common questions about traveling from Myrtle Beach, SC to Tampa, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Tampa, FL, this guide helps you travel smarter and with confidence.

Most Myrtle Beach, SC to Tampa, FL buses use the Myrtle Beach, N Oak St (Bus Station) to Tampa, Marion Transit Center station pair, with some services arriving at Tampa, USF Holly Drive (Central Plant). Use this guide to compare Myrtle Beach, SC and Tampa, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Myrtle Beach, N Oak St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Myrtle Beach, N Oak St (Bus Station). ATMs are available at Myrtle Beach, N Oak St (Bus Station).
Ticket office support is available at Myrtle Beach, N Oak St (Bus Station).
Available at Myrtle Beach, N Oak St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Myrtle Beach, N Oak St (Bus Station): Wheelchair accessible entry available.
Tampa, Marion Transit Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, Marion Transit Center. ATMs are available at Tampa, Marion Transit Center.
Ticket office support is available at Tampa, Marion Transit Center.
Available at Tampa, Marion Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at Tampa, Marion Transit Center: Wheelchair accessible with ramps.
Tampa, USF Holly Drive (Central Plant) is 13 km from Tampa city centre. Public transport options include:
Tampa, USF Holly Drive (Central Plant) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, USF Holly Drive (Central Plant). ATMs are available at Tampa, USF Holly Drive (Central Plant).
Ticket office support is available at Tampa, USF Holly Drive (Central Plant).
Available at Tampa, USF Holly Drive (Central Plant): Parking, Taxis, WC.
Accessibility facilities are available at Tampa, USF Holly Drive (Central Plant): Wheelchair accessible facilities.
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