- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
The best way to find a cheap bus ticket from Myrtle Beach, SC to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Myrtle Beach, SC to Florence, SC will cost around $17 if you buy it on the day, but the cheapest tickets can be found for only $17.
On Wed, Nov 04, we found 2 buses from Myrtle Beach, SC to Florence, SC, including 2 direct services.
On Wed, Nov 04 the direct buses cover the 98 km distance in an average of 1 h 43 m but if you time it right, some buses will get you there in just 1 h 40 m .
On Wed, Nov 04 the slowest buses will take 1 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Myrtle Beach, SC to Florence, SC run on average 1 times per day, taking around 1h 40m. Cheap bus tickets for this journey start at $19 if you book in advance.
There are 1 buses per day. The earliest bus runs at 13:15, the last at 14:10. The fastest bus covers the 60 miles (98 km) distance in 1h 40m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Myrtle Beach, SC to Florence, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:40PM | Arrival Time 02:20PM | Duration 1h40 | Departure days Tue, Wed, Fri | Cheapest price $17 |
Operator Greyhound | Departure Time 01:10PM | Arrival Time 02:55PM | Duration 1h45 | Departure days Tue, Wed, Fri | Cheapest price $17 |
The table below shows live departures for Myrtle Beach, SC to Florence, SC buses for today, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:40 PM Myrtle Beach, N Oak St (Bus Station) | 1h40 | 2:20 PM Florence, S Irby St (Greyhound Bus Stop), SC | 0 transfersDirect | |
![]() | 1:10 PM Myrtle Beach, N Oak St (Bus Station) | 1h45 | 2:55 PM Florence, S Irby St (Greyhound Bus Stop), SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Myrtle Beach, SC to Florence, SC with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
Pulled pork barbecue is a Pee Dee staple, slow-smoked until tender and served with the region's tangy vinegar-pepper sauce.
Smoked pork ribs are common at local barbecue joints, seasoned simply and cooked low and slow for deep smoke flavor.
Shrimp and grits is a South Carolina classic: local shrimp over creamy grits, often enriched with bacon, gravy, or butter.
Upscale downtown restaurant serving refined Southern dishes, steaks, seafood, and cocktails in a polished space.
Casual local favorite for Carolina barbecue, ribs, and classic Southern sides in a relaxed family setting.
Popular casual spot known for barbecue plates, pulled pork, and generous Southern comfort food portions.
Moderate by U.S. small-city standards. Hotels are usually cheaper than major tourist cities, while dining and car-based transport remain fairly typical for the region.
Tip 15-20% at restaurants. Round up or add 10-15% for taxis if service is good. Small change is fine at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Florence, SC.
Find answers to the most common questions about traveling from Myrtle Beach, SC to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

Most Myrtle Beach, SC to Florence, SC buses use the Myrtle Beach, N Oak St (Bus Station) to Florence, S Irby St (Greyhound Bus Stop) station pair. Use this guide to compare Myrtle Beach, SC and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Myrtle Beach, N Oak St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Myrtle Beach, N Oak St (Bus Station). ATMs are available at Myrtle Beach, N Oak St (Bus Station).
Ticket office support is available at Myrtle Beach, N Oak St (Bus Station).
Available at Myrtle Beach, N Oak St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Myrtle Beach, N Oak St (Bus Station): Wheelchair accessible entry available.
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Check bus stations information for Myrtle Beach, SC and Florence, SC, including where buses depart and arrive on this route.