- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Take a bus from Mississauga, ON to Chicago, IL and enjoy the approximately 423 miles (682 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 06:55, the last at 23:15.
Distance 423 miles (682 km) |
First bus 6:55 AM |
Last bus 11:15 PM |
Cheapest Month Sep |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Mississauga, ON to Chicago, IL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:25AM | Arrival Time 09:25PM | Duration 17h00 | Departure days Mon | Cheapest price €113 |
Operator Greyhound | Departure Time 04:55PM | Arrival Time 10:00AM | Duration 18h05 | Departure days Mon | Cheapest price €103 |
Operator FlixBus | Departure Time 11:55PM | Arrival Time 11:20AM | Duration 12h25 | Departure days Mon | Cheapest price €102 |
The table below shows live departures for Mississauga, ON to Chicago, IL buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus+ · | 4:55 PM Mississauga, Duke of York Blvd (Living Arts Centre), ON | 18h05 | 10:00 AM Chicago, Greyhound Bus Station | 3 transfers | |
FlixBus · FlixBus | 11:55 PM Mississauga, Duke of York Blvd (Living Arts Centre), ON | 12h25 | 11:20 AM Chicago, Greyhound Bus Station | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Chicago, IL.
Find answers to the most common questions about traveling from Mississauga, ON to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

Most Mississauga, ON to Chicago, IL buses use the Mississauga, Duke of York Blvd (Living Arts Centre) to Chicago, Greyhound Bus Station station pair. Use this guide to compare Mississauga, ON and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Mississauga, Duke of York Blvd (Living Arts Centre) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Mississauga, Duke of York Blvd (Living Arts Centre). ATMs are available at Mississauga, Duke of York Blvd (Living Arts Centre).
Ticket office support is available at Mississauga, Duke of York Blvd (Living Arts Centre).
Available at Mississauga, Duke of York Blvd (Living Arts Centre): Parking, Taxis, WC.
Accessibility facilities are available at Mississauga, Duke of York Blvd (Living Arts Centre): Wheelchair accessible pavements.
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Snack shop and vending machines available
Free Wi-Fi in waiting area. ATMs are located near entrance.
Ticket office support is available at Chicago, Greyhound Bus Station.
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Check bus stations information for Mississauga, ON and Chicago, IL, including where buses depart and arrive on this route.
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