Travel Information
Compare bus, train, and flight for Mission Viejo, CA to San Francisco, CA
Omio recommends booking the flight as it is the most popular option from Mission Viejo, CA to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from $67. For those with little time consider booking a flight which can get you there in 1h 32m. The ticket price range depends on the travel mode: a bus costs an average of $67, and a flight costs an average of $159.
Distance: 392 miles (632 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
$70 Average price Cheapest | $230 Average price | $72 Average price |
12h 6m Average total duration 11h 36m Onboard + 30m Additional time* | 4h 32m Average total duration Fastest 1h 32m Onboard + 3h 0m Additional time* | 12h 46m Average total duration 12h 16m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Mission Viejo, CA to San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Mission Viejo, CA to San Francisco, CA
Buses from Mission Viejo, CA to San Francisco, CA run on average 27 times per day, taking around 11h 36m. Cheap bus tickets for this journey start at $67 (€54) if you book in advance.
There are 3 buses per day. The earliest bus runs at 04:55, the last at 23:25. The fastest bus covers the 392 miles (632 km) distance in 11h 48m.
Distance 392 miles (632 km) |
Average bus duration 11h 36m |
Cheapest ticket price $67 (€54) |
Buses per day 27 |
Direct buses 3 |
Fastest bus 11h 48m |
First bus 04:55 |
Last bus 23:25 |
Cheapest month Dec |
Cheapest day Wed |
High season Apr - Jun |
Low season Oct - Dec |
Bus providers: Amtrak from Mission Viejo, CA to San Francisco, CAYou can travel by bus between Mission Viejo, CA to San Francisco, CA with Amtrak for as low as $67 (€54). When you search for schedules and tickets, Omio will show you the best journey
Amtrak
FAQs: Bus from Mission Viejo, CA to San Francisco, CA
Find answers to the most common questions about traveling from Mission Viejo, CA to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Amtrak
- Wheelchair spaces, accessible restrooms, Red Cap assistance service, accessible platforms and stations
- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
- Amtrak
- Cancellation policies depend on ticket type and timing
- Amtrak
- 2 personal items and 2 carry-on bags included free
- Amtrak
- Small pets under 20 pounds allowed for $26 fee. Must be in carrier. Service animals travel free
popular bus stations
Popular bus stations from Mission Viejo, CA to San Francisco, CA
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