- Must visit
USS Midway Museum
Museum aboard the historic aircraft carrier USS Midway with restored aircraft, flight deck exhibits, and audio tours on San Diego Bay.
Take a bus from Millbrae, CA to San Diego, CA and enjoy the approximately 448 miles (721 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
There are 1 buses per day. The earliest bus runs at 00:05, the last at 23:25.
Distance 448 miles (721 km) |
Buses per day 23 |
Direct buses 1 |
First bus 12:05 AM |
Last bus 11:25 PM |
Cheapest Month Nov |
Cheapest Day Fri |
High Season Jan - Mar |
Low Season Jan - Mar |
Best time to book 2 days |
Discover the best of San Diego — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego trip today.
Museum aboard the historic aircraft carrier USS Midway with restored aircraft, flight deck exhibits, and audio tours on San Diego Bay.
Balboa Park art museum known for Spanish old masters, South Asian works, and rotating exhibitions in a landmark building.
Leading contemporary art museum with major postwar and current works, especially strong in Southern California and Pacific Rim artists.
Vast cultural park with gardens, museums, Spanish Colonial Revival architecture, walking paths, and some of San Diego's best photo spots.
Scenic cove known for sea lions, clear water, coastal cliffs, and highly shareable sunset and ocean-view walks.
Wide sandy beach beside the Hotel del Coronado, popular for walking, photography, and classic Southern California scenery.
Beer-battered or grilled local fish in tortillas, usually topped with cabbage, crema, and salsa. A signature coastal San Diego staple with strong Baja influence.
A San Diego original burrito filled with carne asada, fries, cheese, and salsa. It is one of the city’s most iconic late-night and casual foods.
French fries topped with carne asada, cheese, guacamole, sour cream, and salsa. This indulgent dish is strongly associated with San Diego taco shop culture.
Popular waterfront seafood restaurant serving fresh local catch, fish tacos, and sandwiches in a relaxed harbor setting near the fishing fleet.
Historic, no-frills Mexican restaurant famous for house-made tortillas, rolled tacos, and comforting traditional plates. A beloved local institution with a classic atmosphere.
Iconic casual spot in Ocean Beach known for oversized burgers, fries, and a lively beach-town vibe. A long-standing San Diego favorite.
Prices are high by U.S. standards, especially for hotels, dining, and parking near the coast and downtown.
Tip 18-20% at restaurants, 20%+ for great service. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and valet.
Find answers to the most common questions about traveling from Millbrae, CA to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.

Most Millbrae, CA to San Diego, CA buses use the San Francisco, Transit Center Bay 29 to San Diego, Congress Street (Old Town Park) station pair, with some services arriving at La Jolla, UCSD Health La Jolla Station. Use this guide to compare Millbrae, CA and San Diego, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
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