- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Cheapest price
CHF37
Average price
CHF45
Fastest journey
5 h 10 m
Average duration
6 h
Buses per day
8
Distance
431 km
The best way to find a cheap bus ticket from Louisville, KY to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Louisville, KY to Chicago, IL will cost around CHF45 if you buy it on the day, but the cheapest tickets can be found for only CHF37.
Of the 8 buses that leave Louisville, KY for Chicago, IL on Tue, Aug 04, 8 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Aug 04 the direct buses cover the 431 km distance in an average of 6 h but if you time it right, some buses will get you there in just 5 h 10 m .
On Tue, Aug 04 the slowest buses will take 6 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


FlixBus
FlixBus
FlixBus



Buses from Louisville, KY to Chicago, IL run on average 8 times per day, taking around 6h 17m. Cheap bus tickets for this journey start at CHF37 if you book in advance.
There are 8 buses per day. The earliest bus runs at 01:50, the last at 23:45. The fastest bus covers the 267 miles (431 km) distance in 5h 40m.
Distance 267 miles (431 km) |
Average bus duration 6h 17m |
Cheapest ticket price CHF37 |
Buses per day 8 |
Direct buses 8 |
Fastest bus 5h 40m |
First bus 1:50 AM |
Last bus 11:45 PM |
Cheapest Month Nov |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Thu |
Least Busy Day Sun |
Best time to book 28 days |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 03:00AM | Arrival Time 08:00AM | Duration 6h00 | Departure days Everyday | Cheapest price CHF45 |
Operator FlixBus | Departure Time 04:45AM | Arrival Time 11:30AM | Duration 7h45 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price CHF41 |
Operator Greyhound | Departure Time 07:35AM | Arrival Time 01:45PM | Duration 7h10 | Departure days Everyday | Cheapest price CHF44 |
Operator Greyhound | Departure Time 10:15AM | Arrival Time 03:15PM | Duration 6h00 | Departure days Everyday | Cheapest price CHF37 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 08:10PM | Duration 6h25 | Departure days Everyday | Cheapest price CHF37 |
Operator FlixBus | Departure Time 08:00PM | Arrival Time 12:10AM | Duration 5h10 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price CHF38 |
The table below shows live departures for Louisville, KY to Chicago, IL buses for today, Monday, August 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:00 AM Louisville, W Broadway (Greyhound Bus Station), KY | 6h00 | 8:00 AM Chicago, Union Station (Amtrak), IL | 0 transfersDirect | |
![]() | 3:00 AM Louisville, W Broadway (Greyhound Bus Station), KY | 6h25 | 8:25 AM Chicago, Greyhound Bus Station | 0 transfersDirect | |
FlixBus | 4:45 AM Louisville, W Broadway (Greyhound Bus Station), KY | 7h45 | 11:30 AM Chicago, Greyhound Bus Station | 0 transfersDirect | |
![]() | 7:35 AM Louisville, W Broadway (Greyhound Bus Station), KY | 7h35 | 2:10 PM Chicago, Greyhound Bus Station | 0 transfersDirect | |
![]() | 7:35 AM Louisville, W Broadway (Greyhound Bus Station), KY | 7h10 | 1:45 PM Chicago, Union Station (Amtrak), IL | 0 transfersDirect | |
![]() | 10:15 AM Louisville, W Broadway (Greyhound Bus Station), KY | 6h00 | 3:15 PM Chicago, Greyhound Bus Station | 0 transfersDirect | |
![]() | 2:45 PM Louisville, W Broadway (Greyhound Bus Station), KY | 6h25 | 8:10 PM Chicago, Greyhound Bus Station | 0 transfersDirect | |
FlixBus | 8:00 PM Louisville, W Broadway (Greyhound Bus Station), KY | 5h10 | 12:10 AM Chicago, Greyhound Bus Station | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
Find answers to the most common questions about traveling from Louisville, KY to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

Most Louisville, KY to Chicago, IL buses use the Louisville, W Broadway (Greyhound Bus Station) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Louisville, KY and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need