- Must visit
Art Institute Of Chicago
One of the world’s leading art museums, famous for Impressionist masterpieces, American art, and major special exhibitions.
Omio recommends booking the flight as it is the most popular option from Guadalupe, CA to Chicago, IL among Omio's users. If you are prioritising price take the flight with prices starting from $355. For those with little time consider booking a flight which can get you there in 8h 20m. The ticket price range depends on the travel mode: a flight costs an average of $355, and a train costs an average of $2225.
Distance: 1832 miles (2949 km)
Most popular Flight | Train | Driving |
|---|---|---|
$355 Average price Cheapest | $2225 Average price | $433 Average price (fuel + tolls) |
11h 20m Average total duration Fastest 8h 20m Onboard + 3h 0m Additional time* | 54h 25m Average total duration 53h 55m Onboard + 30m Additional time* | 31h 30m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Guadalupe, CA to Chicago, IL:
A flight is $1870 (€1535) less than a train for this route with tickets for a train from Guadalupe, CA to Chicago, IL costing on average $2225 (€1826).
Other travel options to Chicago, IL take longer:
Train takes on average 53h 55m.
Compare train and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a bus from Guadalupe, CA to Chicago, IL and enjoy the approximately 1832 miles (2949 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 12:01, the last at 12:01.
Distance 1832 miles (2949 km) |
Buses per day 8 |
First bus 12:01 PM |
Last bus 12:01 PM |
Cheapest Month Nov |
Cheapest Day Sat |
High Season Jan - Mar |
Low Season Oct - Dec |
Discover the best of Chicago — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago trip today.
One of the world’s leading art museums, famous for Impressionist masterpieces, American art, and major special exhibitions.
A top natural history museum known for Sue the T. rex, ancient cultures, fossils, and broad science collections.
A large hands-on science museum with a German submarine, space exhibits, and interactive engineering displays.
Chicago’s signature downtown park, home to Cloud Gate, gardens, public art, and major seasonal events.
The city’s best-known avenue for architecture, shopping, and bustling urban energy along North Michigan Avenue.
A popular pedestrian waterfront with excellent skyline views, bridges, and easy access to boat architecture tours.
A thick, buttery crust pizza baked in a deep pan with layers of cheese, toppings, and chunky tomato sauce. It is one of Chicago’s most iconic and debated local specialties.
An all-beef hot dog on a poppy seed bun topped with yellow mustard, relish, onions, tomato, pickle spear, sport peppers, and celery salt. It is a classic local street food served without ketchup.
Thinly sliced seasoned roast beef piled onto an Italian roll, often dipped in its juices and topped with sweet peppers or giardiniera. It is a defining working-class Chicago sandwich.
Chicago’s world-famous fine-dining restaurant known for highly creative tasting menus and theatrical presentation. It offers one of the city’s most celebrated upscale dining experiences.
A beloved casual institution best known for breaded steak sandwiches and hearty Italian-American comfort food. It has a loyal local following and an old-school atmosphere.
A legendary Chicago chain celebrated for buttery-crust deep-dish pizza and a classic casual atmosphere. One of the city’s best-known places to try this signature dish.
Chicago is pricey for hotels and dining, but budget eats and public transit help keep daily costs manageable.
Tip 18-20% at restaurants; 15-20% for taxis and rideshares; USD 1-2 per drink at bars; USD 1-2 per bag for bellhops; USD 2-5 per night for housekeeping.
Find answers to the most common questions about traveling from Guadalupe, CA to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

Most Guadalupe, CA to Chicago, IL buses use the Santa Maria, Nicholson Avenue / Cypress Street to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Guadalupe, CA and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need