- Must visit
Everson Museum of Art
Major art museum known for American art, ceramics, and a notable I. M. Pei building in Downtown Syracuse.
Omio recommends booking the bus as it is the most popular option from Greenville, NC to Syracuse, NY among Omio's users. If you are prioritising price take the bus with prices starting from $225. For those with little time consider booking a bus which can get you there in 19h 0m. The ticket price range depends on the travel mode: a bus costs an average of $225, and a bus costs an average of $225.
Distance: 517 miles (833 km)
Most popular Bus | Driving |
|---|---|
$225 Average price Cheapest | $124 Average price (fuel + tolls) |
19h 30m Average total duration Fastest 19h 0m Onboard + 30m Additional time* | 9h 51m Average total duration (door-to-door) |
Direct Options | Direct Options |
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 04:00PM | Arrival Time 11:20AM | Duration 19h20 | Departure days Fri | Cheapest price $153 |
Operator Greyhound | Departure Time 06:50PM | Arrival Time 01:35PM | Duration 18h45 | Departure days Fri | Cheapest price $145 |
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Greenville, NC to Syracuse, NY run on average 1 times per day, taking around 19h 0m. Cheap bus tickets for this journey start at $225 (€186) if you book in advance.
The earliest bus runs at 13:55, the last at 18:45. The fastest bus covers the 517 miles (833 km) distance in 19h 0m.
Distance 517 miles (833 km) |
Average bus duration 19h 0m |
Cheapest ticket price $225 (€186) |
Buses per day 1 |
Fastest bus 19h 0m |
First bus 1:55 PM |
Last bus 6:45 PM |
Cheapest Month Feb |
Cheapest Day Fri |
High Season Jan - Mar |
Low Season Jan - Mar |
Discover the best of Syracuse — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Syracuse trip today.
Major art museum known for American art, ceramics, and a notable I. M. Pei building in Downtown Syracuse.
Museum in the 1850 Weighlock Building interpreting the Erie Canal’s history and Syracuse’s canal-era growth.
Interactive science museum in Armory Square with hands-on exhibits and a dome theater, popular with families.
The city’s best-known walkable district with brick streets, historic architecture, nightlife, and frequent social buzz.
Large waterfront park with paved trails, lake views, and some of the area’s most popular walking and cycling routes.
Classic city park known for open lawns, a rose garden, and scenic walks near Syracuse University.
Small potatoes boiled in heavily salted water until the skins wrinkle, then served with butter. A classic Central New York dish strongly associated with Syracuse.
Spicy pasta with chicken, peppers, and a creamy tomato sauce. Though rooted in nearby Utica, it is a beloved regional Central New York comfort dish often found around Syracuse.
Escarole sautéed with hot peppers, garlic, breadcrumbs, and cheese. This Italian American regional specialty is popular across the Syracuse area.
Well-regarded Italian restaurant offering polished regional Italian dishes in a warm, intimate setting on Syracuse's north side.
Popular, established Italian restaurant in Armory Square known for fresh pasta, lively ambiance, and its well-loved spicy hot tomato oil.
Famous, long-running barbecue restaurant near downtown Syracuse known for smoked meats, lively atmosphere, and a classic local dining experience.
Costs are moderate by U.S. standards. Casual dining is affordable, while hotels and downtown dining can cost more during busy periods.
Tip 18-20% in restaurants; 20%+ for excellent service. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and delivery drivers.
Find answers to the most common questions about traveling from Greenville, NC to Syracuse, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Syracuse, NY, this guide helps you travel smarter and with confidence.

Most Greenville, NC to Syracuse, NY buses use the Greenville, S Pitt St (Butterfield Transportation Center) to Syracuse, Walsh Cir (Syracuse Bus Station) station pair. Use this guide to compare Greenville, NC and Syracuse, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
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