Chicago, IL to Tupelo, MS Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 09:45AM | Arrival Time 11:05PM | Duration 13h20 | Departure days Wed | Cheapest price $126 |
Operator Greyhound | Departure Time 10:30PM | Arrival Time 10:40AM | Duration 12h10 | Departure days Wed | Cheapest price $136 |
Journey information
Overview: Bus from Chicago, IL to Tupelo, MS
Take a bus from Chicago, IL to Tupelo, MS and enjoy the approximately 527 miles (849 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 05:35, the last at 23:15.
Distance 527 miles (849 km) |
Buses per day 3 |
First bus 5:35 AM |
Last bus 11:15 PM |
Cheapest Month Jun |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Apr - Jun |
FAQs: Bus from Chicago, IL to Tupelo, MS
Find answers to the most common questions about traveling from Chicago, IL to Tupelo, MS by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Tupelo, MS, this guide helps you travel smarter and with confidence.

popular bus stations
Popular bus stations from Chicago, IL to Tupelo, MS
Most Chicago, IL to Tupelo, MS buses use the Chicago, Greyhound Bus Station to Tupelo, S Eason Blvd (Brothers Quick Stop) station pair. Use this guide to compare Chicago, IL and Tupelo, MS bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to Tupelo, MS
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