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Journey information
Overview: Bus from Chicago, IL to Tupelo, MS
Take a bus from Chicago, IL to Tupelo, MS and enjoy the approximately 527 miles (849 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 05:35, the last at 23:15.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 527 miles (849 km) |
Buses per day 4 |
First bus 05:35 |
Last bus 23:15 |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
FAQs: Bus from Chicago, IL to Tupelo, MS
Find answers to the most common questions about traveling from Chicago, IL to Tupelo, MS by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Tupelo, MS, this guide helps you travel smarter and with confidence.

The first bus from Chicago, IL to Tupelo, MS leaves at 5: 35AM. Plan your trip with the Journey Planner from Omio.
The last bus from Chicago, IL to Tupelo, MS leaves at 11: 15PM.
A day trip to Tupelo, MS from Chicago, IL is worth doing with a journey time of min each way. Check with Omio app the best way to travel.
No, the bus from Chicago, IL to Tupelo, MS has no accessibility options.
No, there are no bathrooms on board the bus from Chicago, IL to Tupelo, MS.
No, bikes are not allowed on board the bus from Chicago, IL to Tupelo, MS.
To find the cheapest bus tickets for your trip from Chicago, IL to Tupelo, MS, follow these tips:
Start your search now and compare ticket prices to find the best deal!
Yes, there is food available to purchase on board the bus from Chicago, IL to Tupelo, MS.
No, luggage for the bus from Chicago, IL to Tupelo, MS needs to be booked in addition.
No, there are no additional luggage options for the bus from Chicago, IL to Tupelo, MS.
Unfortunately, pets are not allowed on the bus from Chicago, IL to Tupelo, MS.
No, there are no USB plugs on board the bus from Chicago, IL to Tupelo, MS.
No, there is no WiFi on board the bus from Chicago, IL to Tupelo, MS.
popular bus stations
Popular bus stations from Chicago, IL to Tupelo, MS
Chicago
Tupelo
The major bus station for departures in Chicago is Chicago, Greyhound Bus Station. Find all the information you need to know about services, amenities and connections at Chicago, Greyhound Bus Station for your trip from Chicago to Tupelo.
Chicago, Greyhound Bus Station
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Chicago, Union Station (Amtrak)
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The major bus station for arrivals in Tupelo is Tupelo, S Eason Blvd (Brothers Quick Stop). Find all the information you need to know about services, amenities and connections at Tupelo, S Eason Blvd (Brothers Quick Stop) for your trip to Tupelo from Chicago.
Tupelo, S Eason Blvd (Brothers Quick Stop)
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Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to Tupelo, MS
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