- Recommended
Oren Dunn City Museum
Main local history museum with exhibits on Tupelo, the region, music heritage, and changing community life.
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Travel Information
Compare bus for Chicago, IL to Tupelo, MS
Omio recommends booking the bus as it is the most popular option from Chicago, IL to Tupelo, MS among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $136 For those with little time, consider booking a bus, which has an average total journey time of 12h 24m. Average ticket prices depend on the travel mode: a bus costs an average of $136, while a bus costs an average of $136.
Distance: 527 miles (849 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
$136 Average price Cheapest | $27 Average price (fuel + tolls) |
12h 24m Average total duration Fastest 11h 54m Onboard + 30m Additional time* | 9h 12m Average total duration (door-to-door) |
 Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
The cheapest way to travel from Chicago, IL to Tupelo, MS is a bus with an average price of $136.
The fastest way to travel from Chicago, IL to Tupelo, MS is by bus with an average journey time of 11h 54m.
Yes, you can take a bus between Chicago, IL and Tupelo, MS.
We recommend using the bus as it is the most popular way to get from Chicago, IL to Tupelo, MS among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $136 compared to roughly $27 in fuel and tolls — a saving of about $-109.23. The journey takes 11h 54m versus 9h 12m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Why should you book Chicago, IL to Tupelo, MS buses with Omio?
Greyhound as well as FlixBus offer buses services from Chicago, IL to Tupelo, MS.
Omio is an official ticket reseller for all your travel options from Chicago, IL to Tupelo, MS.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Chicago, IL to Tupelo, MS.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Chicago, IL to Tupelo, MS.
Journey information
Overview: Bus from Chicago, IL to Tupelo, MS
USAUSA
Buses from Chicago, IL to Tupelo, MS run on average 2 times per day, taking around 11h 54m. Cheap bus tickets for this journey start at $117 if you book in advance.
The earliest bus runs at 05:35, the last at 23:15. The fastest bus covers the 527 miles (849 km) distance in 11h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 527 miles (849 km) |
Average bus duration 11h 54m |
Cheapest ticket price $117 |
Buses per day 2 |
Fastest bus 11h 0m |
First bus 5:35 AM |
Last bus 11:15 PM |
Cheapest Month Jun |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Apr - Jun |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Chicago, IL to Tupelo, MSYou can travel by bus between Chicago, IL to Tupelo, MS with Greyhound, FlixBus for as low as $117. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
12h 45m
Cheapest FlixBus Price
$117
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
11h 0m
Cheapest Greyhound Price
$117
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Tupelo, MS
Things to do in Tupelo, MS
Discover the best of Tupelo, MS — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Tupelo, MS trip today.
- Recommended
Healthworks! Kids Museum
Hands-on museum for children with interactive exhibits that make it a practical family stop in Tupelo.
- Recommended
Elvis Presley Memorial Museum
Compact memorial museum at Elvis Presley Birthplace with artifacts and displays about his youth and family in Tupelo.
- Recommended
Ballard Park
Major city park with trails, ponds, playgrounds, and event space; ideal for walking and relaxed outdoor time.
- Recommended
Main Street
Downtown main street area with historic storefronts, local shops, murals, and a pleasant walkable atmosphere.
Veterans Park
Lakeside park with walking paths, open lawns, and a calm setting for short strolls near central Tupelo.
FAQs: Bus from Chicago, IL to Tupelo, MS
Find answers to the most common questions about traveling from Chicago, IL to Tupelo, MS by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Tupelo, MS, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Chicago, IL to Tupelo, MS can start from as little as $117 when you book in advance. The average bus ticket price for Chicago, IL to Tupelo, MS is $136 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Chicago, IL to Tupelo, MS is 11h 0m to travel the 527 miles (849 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Chicago, IL to Tupelo, MS leaves at 5:35 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Chicago, IL to Tupelo, MS leaves at 11:15 PM.
There are 2 buses a day from Chicago, IL to Tupelo, MS which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Chicago, IL to Tupelo, MS, you can count on Greyhound, FlixBus for the best way to get you to Tupelo, MS. You can also check all possible bus companies who offer a service between Chicago, IL and Tupelo, MS and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Chicago, Greyhound Bus Station, which is located around 1 miles (2 km) away from the city centre, and they get off the bus at Tupelo, S Eason Blvd (Brothers Quick Stop), MS, located 2 away from the city centre.
A trip to Tupelo, MS from Chicago, IL is worth doing but not as a day trip with a journey time of 11h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Chicago, IL to Tupelo, MS is June.
Yes, you can take a bus between Chicago, IL and Tupelo, MS.
Yes, the following accessibility options are available when taking the bus from Chicago, IL to Tupelo, MS:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Chicago, IL to Tupelo, MS for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Chicago, IL to Tupelo, MS depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Chicago, IL to Tupelo, MS.
Yes, the following luggage options are included when booking a bus ticket from Chicago, IL to Tupelo, MS:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Chicago, IL to Tupelo, MS:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Chicago, IL to Tupelo, MS. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Chicago, IL to Tupelo, MS with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Chicago, IL to Tupelo, MS with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Chicago, IL to Tupelo, MS with the following bus company: Greyhound, FlixBus.
Since neither Chicago, IL nor Tupelo, MS are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Chicago, IL to Tupelo, MS among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Tupelo, MS, travelers should be cautious of common safety concerns such as petty theft and vehicle break-ins, especially in crowded or tourist-heavy areas. It is advisable to keep valuables secure and be aware of surroundings. Scams are relatively uncommon but travelers should remain vigilant against overcharging or misleading offers from unofficial vendors. Staying in well-populated areas and using trusted transportation options helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Chicago, IL to Tupelo, MS
Most Chicago, IL to Tupelo, MS buses use the Chicago, Greyhound Bus Station to Tupelo, S Eason Blvd (Brothers Quick Stop) station pair. Use this guide to compare Chicago, IL and Tupelo, MS bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Chicago
Arrival bus stations in Tupelo
Which Chicago, IL station do buses to Tupelo, MS leave from?
Buses from Chicago, IL to Tupelo, MS leave from Chicago, Greyhound Bus Station. The station is 1 miles (3 km) from Chicago, IL city centre at 630 W Harrison St, Chicago, IL 60607, USA.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USA
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Bus7 · 8m · $4 · every ~6 min
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Which Tupelo, MS station do buses from Chicago, IL arrive at?
Buses from Chicago, IL to Tupelo, MS arrive at Tupelo, S Eason Blvd (Brothers Quick Stop). Tupelo, S Eason Blvd (Brothers Quick Stop) is 1 miles (3 km) from Tupelo, MS city centre.
Tupelo, S Eason Blvd (Brothers Quick Stop)S Eason Blvd, Tupelo, MS, USA
City-centre transport
Getting to Tupelo, S Eason Blvd (Brothers Quick Stop) from Tupelo city centre
Tupelo, S Eason Blvd (Brothers Quick Stop) is 2 km from Tupelo city centre. Public transport options include:
FALSE
Tupelo, S Eason Blvd (Brothers Quick Stop) bus station facilities and services
Tupelo, S Eason Blvd (Brothers Quick Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Tupelo, S Eason Blvd (Brothers Quick Stop). ATMs are available at Tupelo, S Eason Blvd (Brothers Quick Stop).
Tickets and information
Ticket office support is available at Tupelo, S Eason Blvd (Brothers Quick Stop).
Parking, taxis and toilets
Available at Tupelo, S Eason Blvd (Brothers Quick Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Tupelo, S Eason Blvd (Brothers Quick Stop): No dedicated facilities for disabled access.
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to Tupelo, MS
Here are some other resources that might have the information you need
Most popular buses to and from Tupelo, MS and Chicago, IL
Most popular bus connections to Tupelo, MS
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