Taking the bus is the cheapest way to travel from Manchester to Dublin. Buses traveling from Manchester to Dublin depart from Manchester Sackville Stree bus station and take at least 10:15 h to arrive at Dublin's Port bus station. There is usually just 1 bus that travels from Manchester to Dublin per day departing Manchester at 7:45 p.m. and arriving in Dublin at 6:00 a.m. the next morning. National Express is the main bus company that travels from Manchester to Dublin.

Taking a flight is the fastest way to travel from Manchester to Dublin. Flights traveling from Manchester to Dublin depart from Manchester's airport and arrive at Dublin's airport after just 55 minutes of flight time. Taking a flight from Manchester to Dublin is still the fastest way to travel even when travel time to and from Manchester and Dublin's airports is taken into consideration. Airlines that fly directly from Manchester to Dublin include British Airways, RyanAir, and Aer Lingus.

Taking a flight is the most popular way to travel from Manchester to Dublin. Taking a flight is almost 3 ½ hours faster than taking the train when travel time to and from Manchester and Dublin's airports is considered while only being €21 more expensive on average. Alternatively, flights are almost 6½ hours faster than taking the bus, while only being €29 more expensive on average. Approximately 14 direct flights travel from Manchester to Dublin per day, with the first departing Manchester at approximately 6 a.m.