Taking the bus is the cheapest way to travel from Birmingham to London with next-day bus tickets starting from €5. National Express buses that travel from Birmingham to London depart from Birmingham coach station and arrive at London Victoria coach station after approximately 2:35 hours of travel time. Approximately 50 buses travel from Birmingham to London every day with the first departing Birmingham at 3:00 a.m.

The fastest way to travel from Birmingham to London is by taking a flight. A Birmingham to London flight usually requires only an hour of flight time; however, when transport to and from the Birmingham and London airports are taken into consideration, the journey will take approximately 5 hours. Flights traveling from Birmingham to London depart from Manchester airport and arrive at either London's Heathrow, Gatwick, Stansted, or City airport. British Airways offer approximately 7 direct flights to London every day.

Taking the train is the most popular way to travel from Birmingham to London. Taking the train is at least an hour faster than taking the bus and approximately 3.5 hours faster than flying when travel to and from Birmingham and London's airports is considered. Trains traveling from Birmingham to London depart from either Moor Street or New Street train station and arrive at either London's Marylebone or Euston train station after approximately 1:22 hours of travel time. Train companies that travel from Birmingham to London include Virgin Trains and Chiltern Railways. Approximately 10 trains travel from Birmingham to London every day.