Taking the bus is usually the cheapest way to travel from Barcelona to Pamplona. Buses traveling from Barcelona to Pamplona depart from Barcelona's Nord bus station and take at least 6½ hours to arrive at Pamplona's bus station. Usually around 9 buses travel from Barcelona to Pamplona per day, with the first bus departing Barcelona at 7:00 a.m. All buses traveling from Barcelona to Pamplona are operated by Alsa.

Taking a flight is technically the fastest way to travel from Barcelona to Pamplona; however, when travel time to and from Barcelona and San Sebastian's airports is taken into consideration, taking a train is actually the fastest way to travel from Barcelona to Pamplona. Flights traveling from Barcelona to Pamplona depart from Barcelona's El Prat airport and land at San Sebastian's airport after 1:10 h of flight time. Travelers will then need to travel approximately 60 km from San Sebastian to Pamplona. There are 2 direct flights from Barcelona to San Sebastian per day, with both flights departing Barcelona at approximately 6 p.m. There are also numerous indirect flights traveling from Barcelona to Pamplona every day.

Taking a train is the most popular way to travel from Barcelona to Pamplona. Trains are almost 3 hours faster than taking the bus while being approximately the same price. Taking the train is also 1:15 h faster than taking a flight when travel time to and from Barcelona and San Sebastian's airports is taken into consideration. Trains traveling from Barcelona to Pamplona depart from Barcelona's Sants train station and take at least 3:45 h to arrive at Pamplona's train station. Usually, 5 trains travel from Barcelona to Pamplona per day, with the first train departing Barcelona at 7:30 a.m. All trains are operated by Renfe.