- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Omio recommends booking the train as it is the most popular option from Seiano to Rome among Omio's users. If you are prioritising price take the bus with prices starting from $9. For those with little time consider booking a flight which can get you there in 57m. The ticket price range depends on the travel mode: a bus costs an average of $9, and a flight costs an average of $80.
Distance: 132 miles (213 km)
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$81 Average price | $10 Average price Cheapest | $109 Average price | $52 Average price (fuel + tolls) |
1h 43m Average total duration 1h 13m Onboard + 30m Additional time* | 3h 40m Average total duration 3h 10m Onboard + 30m Additional time* | 3h 57m Average total duration Fastest 57m Onboard + 3h 0m Additional time* | 3h 13m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Seiano to Rome:
A bus is $72 (€58) less than a train for this route with tickets for a train from Seiano to Rome costing on average $81 (€65).
A bus is $100 (€80) less than a flight for this route with tickets for a flight from Seiano to Rome costing on average $109 (€88).
Other travel options to Rome take longer:
Train takes on average 1h 13m.
Bus takes on average 3h 10m.
You'll arrive about 2h 0m sooner (1h 13m by train vs 3h 13m by car). Tickets start at around $81 (€65) compared to roughly $52 (€41) in fuel and tolls — so you're paying a bit more, but getting hours of your day back, a city-centre arrival, and the freedom to work or relax instead of drive.
Direct services run with Italo.
Driving makes more sense if you're travelling as a group (where fuel costs split several ways), want to stop along the way, or need a car once you arrive.
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Seiano to Rome run on average 3 times per day, taking around 1h 13m. Cheap train tickets for this journey start at $39 (€31) but you can travel from only $9 (€7) by bus.
The earliest train runs at 05:14, the last at 23:10. The fastest train covers the 132 miles (213 km) distance in 2h 11m.
Distance 132 miles (213 km) |
Average train duration 1h 13m |
Cheapest ticket price $39 (€31) |
Trains per day 3 |
Fastest train 2h 11m |
First train 5:14 AM |
Last train 11:10 PM |
Cheapest Month Apr |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 70 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Roma Termini -> Piazza Di Spagna, Rome
Find answers to the most common questions about traveling from Seiano to Rome by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Seiano to Rome trains use the Sant'Agnello to Roma Termini station pair, with some services arriving at Roma Tiburtina. Use this guide to compare Seiano and Rome train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Roma Termini is 1 km from Rome city centre. Public transport options include:
Roma Termini has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Acafe, Moka Café, Roadhouse Grill, McDonald's, Gusto, Chef Express, Coop Minimarket, Mercato Centrale
Free WiFi in the station. ATMs are there are ATMs in various locations around the station.
The ticket office is open Mon - Sun: 06:30 - 22:00. Information desks are located near Platform 24.
Luggage storage is provided by KiPoint and located on Platform 24. Open every day from 06:00 to 23:00.
Available at Roma Termini: Parking, Taxis, WC.
Available at Roma Termini: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Termini: The Sala Blu, Trenitalia's office of assistance for disabled travelers, is located next to Platform 1.
Nearby hotels include Archi di Roma Guest House, Gemma di Roma, The Liberty Boutique Hotel.
Roma Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma Tiburtina has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Rock n’ Coffee Roma, Arabian Kebab, Ingredienti, McDonald’s, Numb's Bakery Café
Free, limited Wi-Fi available in the station for 15 minutes. ATMs are located on the ground floor level.
The ticket office is open Mon - Sun: 06:35 - 20:20. Information desks are located inside the main terminal. .
Luggage storage is luggage lockers are located in the station lobby.
Available at Roma Tiburtina: Parking, Taxis, WC.
Available at Roma Tiburtina: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Tiburtina: Accessible facilities include elevators and escalators.
Nearby hotels include B&B Rome Tiburtina, B&B Alba Domus Roma, Hotel delle Province.
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