- Must visit
Nasher Museum of Art
Major art museum at Duke with global collections, rotating exhibitions, and strong programs in modern and classical art.
The best way to find a cheap flight ticket from Tampa, FL to Durham, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Tampa, FL to Durham, NC will cost around $308 if you buy it on the day, but the cheapest tickets can be found for only $262.
On Wed, Nov 04, we found 2 flights from Tampa, FL to Durham, NC, including 2 direct services.
On Wed, Nov 04 the direct flights cover the 955 km distance in an average of 4 h 52 m but if you time it right, some flights will get you there in just 4 h 25 m .
On Wed, Nov 04 the longest flights will take 5 h 19 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Flights from Tampa, FL to Durham, NC depart on average 103 times per day, taking around 4h 28m. Cheap flight tickets for this journey start at $102 but you can travel from only $99 by train.
There are 2 flights per day. The earliest flight runs at 05:00, the last at 21:53. The fastest flight covers the 593 miles (955 km) distance in 1h 43m. March is the cheapest month to fly.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Tampa, FL to Durham, NC.
The table below shows live departures for Tampa, FL to Durham, NC flights for today, Tuesday, November 3. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:00 PM Tampa, FL | 1h58 | 1:58 PM Durham, NC | 0 transfersDirect | |
![]() | 10:00 PM Tampa, FL | 4h50 | 2:50 AM Durham, NC | 0 transfersDirect | |
![]() | 10:41 PM Tampa, FL | 5h19 | 4:00 AM Durham, NC | 0 transfersDirect | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Flights from Tampa, FL to Durham, NC with United, American Airlines, and CitizenPlane. Flights with a stop available on this route with United, American Airlines, and JetBlue Airways. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Durham, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Durham, NC trip today.
Major art museum at Duke with global collections, rotating exhibitions, and strong programs in modern and classical art.
Hands-on science museum with aerospace, physics, wildlife, and family exhibits in downtown Durham.
Historic site and museum exploring Washington Duke, tobacco farming, and Durham's industrial origins.
Beloved public garden with terraces, woodland paths, and seasonal blooms, ideal for a scenic walk near Duke.
Lively downtown district for walking among warehouses, public art, music venues, and restored tobacco-era spaces.
Scenic riverside greenway for walking and cycling, connecting downtown with quiet stretches of restored nature.
Eastern North Carolina chopped pork barbecue with a tangy vinegar-pepper sauce. A defining regional staple widely loved across Durham and the Triangle.
Slow-cooked pork shoulder or whole hog, often served on a plate with slaw and hush puppies. It reflects the area’s deep barbecue tradition.
Fried cornmeal batter balls served with barbecue or seafood. They are a classic Southern side found on many Durham menus.
Refined restaurant showcasing seasonal North Carolina ingredients with polished service. Known for elevated Southern cooking and a stylish setting.
Beloved local bakery and café serving excellent pastries, breads, and coffee. A dependable stop for breakfast, lunch, or a quick snack.
Popular casual spot for inventive biscuit sandwiches, shrimp and grits, and Southern brunch favorites in a lively downtown atmosphere.
Moderate for a US college city; hotels and dining are mid-priced, transit is limited, but many casual meals and coffee shops are affordable.
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if service is provided.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Durham, NC.
Find answers to the most common questions about traveling from Tampa, FL to Durham, NC by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Durham, NC, this guide helps you travel smarter and with confidence.

Most Tampa, FL to Durham, NC flights use the Tampa International Airport to airport pair. Use this guide to compare Tampa, FL and Durham, NC airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Tampa International Airport is 5 km from Tampa city centre. Public transport options include:
Tampa International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food options include: Restaurants are located in all terminals, including fast food, cafes, and sit-down options like Columbia Cafe and P.F. Chang's.
Free Wi-Fi available throughout the airport. ATMs are located throughout the airport, near gates and baggage claimas.
Lost and found is available at the station.
Available at Tampa International Airport: Parking, Taxis, WC.
Available at Tampa International Airport: Car Rental.
Accessibility facilities are available at Tampa International Airport: Elevators, ramps.
Nearby hotels include Hotels like the Tampa Airport Marriott are located within the airport complex..
Saint Pete-Clearwater International Airport is 2 km from Tampa city centre. Public transport options include:
Saint Pete-Clearwater International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Lounge, Lost and Found Office, and Car Rental.
Food options include: Restaurants are available, including fast food and sit-down options like Dunkin' and Sam Adams Grille.
Free Wi-Fi available throughout the airport. ATMs are located in the terminal near the baggage claim area.
Lost and found is available at the station.
Available at Saint Pete-Clearwater International Airport: Parking, Taxis, WC.
Available at Saint Pete-Clearwater International Airport: Car Rental.
Accessibility facilities are available at Saint Pete-Clearwater International Airport: Elevators, ramps.