- Must visit
Pinacoteca di Brera
One of Italy’s top art museums, featuring masterpieces by Mantegna, Bellini, Raphael, Caravaggio, and Piero della Francesca.
Omio recommends booking the bus as it is the most popular option from Payerne to Milan among Omio's users. If you are prioritising price take the bus with prices starting from $50. For those with little time consider booking a bus which can get you there in 4h 10m. The ticket price range depends on the travel mode: a bus costs an average of $50, and a flight costs an average of $128.
Distance: 142 miles (230 km)
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$50 Average price Cheapest | $93 Average price | $203 Average price | $78 Average price (fuel + tolls) |
4h 40m Average total duration Fastest 4h 10m Onboard + 30m Additional time* | 4h 51m Average total duration 4h 21m Onboard + 30m Additional time* | 10h 35m Average total duration 7h 35m Onboard + 3h 0m Additional time* | 4h 36m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Payerne to Milan:
A bus is $43 (€36) less than a train for this route with tickets for a train from Payerne to Milan costing on average $93 (€77).
A bus is $154 (€126) less than a flight for this route with tickets for a flight from Payerne to Milan costing on average $203 (€167).
Other travel options to Milan take longer:
Train takes on average 4h 21m.
Flight takes on average 7h 35m.
You'll arrive about 26m sooner (4h 10m by bus vs 4h 36m by car) and save roughly $28 (€23) compared to fuel and tolls ($50 (€41) vs $78 (€64)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by BlaBlaCar.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Gruppo Di Maio | Departure Time 02:40PM | Arrival Time 05:45AM | Duration 15h05 | Departure days Mon, Fri | Cheapest price $50 |
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Payerne to Milan run on average 3 times per day, taking around 4h 10m. Cheap bus tickets for this journey start at $50 (€41) if you book in advance.
There are 2 buses per day. The earliest bus runs at 07:30, the last at 23:45. The fastest bus covers the 142 miles (230 km) distance in 15h 5m.
Distance 142 miles (230 km) |
Average bus duration 4h 10m |
Cheapest ticket price $50 (€41) |
Buses per day 3 |
Direct buses 2 |
Fastest bus 15h 5m |
First bus 7:30 AM |
Last bus 11:45 PM |
High Season Jul - Sep |
Low Season Apr - Jun |
Discover the best of Milan — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Milan trip today.
One of Italy’s top art museums, featuring masterpieces by Mantegna, Bellini, Raphael, Caravaggio, and Piero della Francesca.
This contemporary art museum near Porta Romana presents rotating exhibitions in a striking former industrial distillery complex.
Italy’s leading science museum is set in a former monastery and features Leonardo galleries, trains, aircraft, and a submarine.
Milan’s central square frames the cathedral and major civic buildings, making it the city’s essential meeting point and photo stop.
This artistic district offers charming lanes, Brera atmosphere, boutiques, and easy access to galleries and evening strolls.
A large landscaped park behind the castle, perfect for walks, skyline views, and reaching landmarks like the Arch of Peace.
Saffron risotto cooked with butter, stock and cheese. It is Milan's signature dish, linked to the city's love of rich northern Italian rice cookery.
Breaded veal cutlet fried in butter until golden. A classic Milanese main, prized for its simple preparation and long-standing local tradition.
Slow-braised veal shanks with vegetables, wine and broth, often finished with gremolata. A hearty Lombard specialty commonly paired with risotto.
Three-Michelin-star fine dining by Enrico Bartolini in MUDEC. Expect refined Italian tasting menus in a polished contemporary setting.
Historic Milanese restaurant near the Duomo, famous for risotto and cotoletta. Traditional, elegant rooms and a strong local culinary identity.
Long-running local favorite for classic Milanese cuisine, especially risotto and ossobuco. Warm, old-school atmosphere in the Brera area.
Moderate for Western Europe. Hotels and central dining can be pricey, but transit is affordable and budget meals, aperitivo deals, and local cafes help keep daily costs reasonable.
Tipping is modest. Service may be included. Round up or leave €1-2 at cafes, 5-10% for good restaurant service, and round up taxi fares.
Official public transport app
Orio al Serio, Milan Bergamo Airport (Bus station) -> Milano Centrale, Milan
Find answers to the most common questions about traveling from Payerne to Milan by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milan, this guide helps you travel smarter and with confidence.

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