- Recommended
El Pueblo History Museum
Regional history museum exploring Pueblo's people, industries, and neighborhoods, with exhibits on local culture and changing city life.
Take a bus from Des Moines, IA to Pueblo, CO and enjoy the approximately 626 miles (1008 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 05:30, the last at 22:25.
Distance 626 miles (1008 km) |
First bus 5:30 AM |
Last bus 10:25 PM |
Cheapest Month Jul |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Apr - Jun |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 07:15PM | Arrival Time 09:30PM | Duration 26h15 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $224 |
Discover the best of Pueblo, CO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Pueblo, CO trip today.
Regional history museum exploring Pueblo's people, industries, and neighborhoods, with exhibits on local culture and changing city life.
Hands-on children's museum with interactive science, creativity, and play exhibits that make it an easy family stop in Pueblo.
Visual arts museum with changing exhibitions, regional artists, and programs inside the Sangre de Cristo Arts Center complex.
Riverfront walking district with paths, bridges, seasonal boat rides, and events; a central place for strolling and relaxing downtown.
Historic downtown corridor lined with brick buildings, shops, murals, and event spaces; ideal for walking and experiencing old Pueblo.
Large city park with lake views, trails, open lawns, and the zoo nearby; a favorite green space for casual outdoor time.
Pueblo Chile is the city's signature pepper, prized for its earthy heat and used roasted, fried, or diced into many local dishes.
A Pueblo specialty burger topped with roasted green chiles, often local Pueblo chiles, reflecting the area's strong chile-growing tradition.
Pueblo's famous comfort dish: an open-faced burger smothered with green chile, usually topped with cheese and onions.
Historic local spot best known for the classic slopper and other Pueblo comfort food in a casual, no-frills setting.
Popular casual eatery serving Pueblo favorites, burgers, and green chile dishes with a friendly neighborhood feel.
Long-running Mexican restaurant known for green chile, enchiladas, and hearty regional plates in a relaxed family atmosphere.
Pueblo is budget-friendly by U.S. standards, with lower hotel, dining, and transport costs than larger Colorado cities like Denver or Boulder.
Tip 15-20% at restaurants, $1-2 per drink at bars, and round up or tip 10-15% for taxis. Small tips are appreciated at cafes but not always expected.
Find answers to the most common questions about traveling from Des Moines, IA to Pueblo, CO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Pueblo, CO, this guide helps you travel smarter and with confidence.

Most Des Moines, IA to Pueblo, CO buses use the Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) to Pueblo, Court St / W 2nd St (Pueblo Transit Center) station pair. Use this guide to compare Des Moines, IA and Pueblo, CO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) is 3 km from Des Moines city centre. Public transport options include:
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). ATMs are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Ticket office support is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Parking, Taxis, WC.
Accessibility facilities are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Wheelchair accessible buses available.
Pueblo, Court St / W 2nd St (Pueblo Transit Center) is 1 km from Pueblo city centre. Public transport options include:
Pueblo, Court St / W 2nd St (Pueblo Transit Center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Pueblo, Court St / W 2nd St (Pueblo Transit Center). ATMs are available at Pueblo, Court St / W 2nd St (Pueblo Transit Center).
Ticket office support is available at Pueblo, Court St / W 2nd St (Pueblo Transit Center).
Available at Pueblo, Court St / W 2nd St (Pueblo Transit Center): Parking, Taxis, WC.
Accessibility facilities are available at Pueblo, Court St / W 2nd St (Pueblo Transit Center): Wheelchair accessible.
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