Travel Information
Compare bus and flight for Setúbal to Madrid
Omio recommends booking the bus as it is the most popular option from Setúbal to Madrid among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $34 For those with little time, consider booking a flight, which has an average total journey time of 3h 20m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.5 - 1.2kg. Average ticket prices depend on the travel mode: a bus costs an average of $34, while a flight costs an average of $122.
Distance: 305 miles (492 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$34 Average price Cheapest | $122 Average price | $143 Average price (fuel + tolls) |
8h 11m Average total duration 7h 41m Onboard + 30m Additional time* | 3h 20m Average total duration Fastest 1h 20m Onboard + 2h 0m Additional time* | 5h 25m Average total duration (door-to-door) |
0.5 - 1.2kg CO2 emissions Lowest | 1.5 - 3.0kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Setúbal to Madrid:
A bus is $88 less than a flight for this route with tickets for a flight from Setúbal to Madrid costing on average $122.
Other travel options to Madrid take longer:
Bus takes on average 8h 11m.
Tickets start at around $34 compared to roughly $143 in fuel and tolls — a saving of about $109. The journey takes 7h 41m versus 5h 25m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Setúbal to Madrid
How to get from Setúbal to Madrid by train, bus or flight.
Our recommendation
The best way to travel from Setúbal to Madrid is by taking a bus because it’s the best combination of price and speed.
42491:45 PM7h30Setúbal, Terminal Rodoviário de Setúbal TST10:15 PMMadrid, Estación Sur de Autobuses$281One-way0 transfers
Cheapest
42491:45 PM7h30Setúbal, Terminal Rodoviário de Setúbal TST10:15 PMMadrid, Estación Sur de Autobuses$281One-way0 transfers
Fastest
TP10185:00 PM1h10Humberto Delgado Airport7:10 PMMadrid Barajas Airport$5281One-way0 transfers
Other options
FlixBus · FlixBus3:50 AM14h25Setúbal, Interface Transportes7:15 PMMadrid, Estación Sur de Autobuses$671One-way1 transfer
FlixBus · FlixBus3:50 AM14h55Setúbal, Interface Transportes7:45 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)$761One-way1 transfer
FlixBus · FlixBus · FlixBus5:00 AM17h55Setúbal, Interface Transportes11:55 PMMadrid, Terminal de autobuses T4 (Aeropuerto de Madrid)$1041One-way2 transfers
U276897:00 AM1h15Humberto Delgado Airport9:15 AMMadrid Barajas Airport$2091One-way0 transfers
76897:00 AM1h15Humberto Delgado Airport9:15 AMMadrid Barajas Airport$2141One-way0 transfers
IB5406:35 AM1h25Humberto Delgado Airport9:00 AMMadrid Barajas Airport$2851One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Setúbal to Madrid
Travel to Madrid easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Setúbal to Madrid.

This is compared to other travel options from Setúbal to Madrid:
A bus is $88 less than a flight for this route with tickets for a flight from Setúbal to Madrid costing on average $122.
Other travel options to Madrid take longer:
Bus takes on average 8h 11m.
- Around 25 flights per day.
- Around 6 buses per day.
However, we recommend checking specific travel dates for your route between Setúbal and Madrid as scheduled services by bus and flight can vary by season or day of the week.
- Flights mostly depart from Humberto Delgado Airport and arrive in Madrid Barajas Airport.
- Buses mostly depart from Setúbal, Interface Transportes and arrive in Madrid, Estación Sur de Autobuses.
- Travel with Ryanair, Air Europa, Iberia, Air Nostrum to go to Madrid by flight.
- Travel with BlaBlaCar Bus, Alsa, BlaBlaCar, FlixBus, Rede Expressos to go to Madrid by bus.
- 17 direct flights per day with Air Europa, Iberia, Air Nostrum.
- 4 direct buses per day with BlaBlaCar Bus, BlaBlaCar, Rede Expressos.
Travelling from Setúbal to Madrid: related information
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