Travel Information
Compare bus and flight for Madrid to Setúbal
Omio recommends booking the bus as it is the most popular option from Madrid to Setúbal among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €49 For those with little time, consider booking a flight, which has an average total journey time of 5h 32m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.5 - 1.2kg. Average ticket prices depend on the travel mode: a bus costs an average of €49, while a flight costs an average of €434.
Distance: 305 miles (492 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
€49 Average price Cheapest | €434 Average price | €97 Average price (fuel + tolls) |
10h 39m Average total duration 10h 9m Onboard + 30m Additional time* | 5h 32m Average total duration Fastest 3h 32m Onboard + 2h 0m Additional time* | 5h 34m Average total duration (door-to-door) |
0.5 - 1.2kg CO2 emissions Lowest | 1.5 - 3.0kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Madrid to Setúbal
Compare the available ways to get from Madrid to Setúbal, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Madrid to Setúbal:
A bus is €385 less than a flight for this route with tickets for a flight from Madrid to Setúbal costing on average €434.
Other travel options to Setúbal take longer:
Bus takes on average 10h 39m.
Tickets start at around €49 compared to roughly €97 in fuel and tolls — a saving of about €49. The journey takes 10h 9m versus 5h 34m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Madrid to Setúbal
How to get from Madrid to Setúbal by train, bus or flight.
Our recommendation
The best way to travel from Madrid to Setúbal is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus9:25 AM 20h30 Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) 4:55 AM Setúbal, Interface Transportes €46 1 One-way 2 transfers
Cheapest
FlixBus · FlixBus · FlixBus9:25 AM 20h30 Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) 4:55 AM Setúbal, Interface Transportes €46 1 One-way 2 transfers
Fastest
TP10237:40 AM 1h15 Madrid Barajas Airport 7:55 AM Humberto Delgado Airport €355 1 One-way 0 transfers
Other options
FlixBus · FlixBus · FlixBus8:15 AM 20h30 Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) 3:45 AM Setúbal, Interface Transportes €47 1 One-way 2 transfers
FlixBus · FlixBus · FlixBus3:00 PM 24h45 Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) 2:45 PM Setúbal, Interface Transportes €52 1 One-way 2 transfers
FlixBus · FlixBus · FlixBus7:30 AM 17h05 Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) 11:35 PM Setúbal, Interface Transportes €59 1 One-way 2 transfers
U276469:25 PM 1h25 Madrid Barajas Airport 9:50 PM Humberto Delgado Airport €73 1 One-way 0 transfers
FR 94404:50 PM 1h25 Madrid Barajas Airport 5:15 PM Humberto Delgado Airport €107 1 One-way 0 transfers
U2764010:30 AM 1h30 Madrid Barajas Airport 11:00 AM Humberto Delgado Airport €125 1 One-way 0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Madrid to Setúbal
Travel to Setúbal easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Madrid to Setúbal.

This is compared to other travel options from Madrid to Setúbal:
A bus is €385 less than a flight for this route with tickets for a flight from Madrid to Setúbal costing on average €434.
Other travel options to Setúbal take longer:
Bus takes on average 10h 39m.
- Around 30 flights per day.
- Around 3 buses per day.
However, we recommend checking specific travel dates for your route between Madrid and Setúbal as scheduled services by bus and flight can vary by season or day of the week.
- Flights mostly depart from Madrid Barajas Airport and arrive in Humberto Delgado Airport.
- Buses mostly depart from Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) and arrive in Setúbal, Interface Transportes.
- Travel with British Airways, TAP Portugal, Iberia, Air Europa, Qatar Airways, easyJet, Royal Air Maroc, Ryanair, CitizenPlane, Vueling, Lot Polish Airlines to go to Setúbal by flight.
- Travel with FlixBus, BlaBlaCar Bus, Alsa, Internorte to go to Setúbal by bus.
- 17 direct flights per day with TAP Portugal, Iberia, Air Europa, easyJet, Ryanair, CitizenPlane.
- 1 direct buses per day with BlaBlaCar Bus, Alsa, Internorte.
Travelling from Madrid to Setúbal: related information
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