Taking the bus is the cheapest way to travel from Liverpool to London with next-day bus tickets starting from €18. National Express buses that travel from Liverpool to London depart from Liverpool's Norton Street bus station and arrive at either London's Victoria bus station or Sutton rail station after nearly 6 hours of travel time. Bus trips that require stops have longer travel times. Approximately 20 buses travel from Liverpool to London on weekdays with the first departing Liverpool at 5:00 a.m. Fewer buses travel from Liverpool to London on the weekend.

With only an hour of flight time required, the fastest way to travel from Liverpool to London is technically by taking a flight. However, when travel time to and from London and Liverpool's airports are taken into consideration, the journey will take nearly 5 hours. There are no direct flights from Liverpool's airport to any of London's airports. All flights from Liverpool that arrive in London require a transfer, while "direct" flights to London actually depart from Manchester airport. British Airways offers direct flights from Manchester to London 10 times per day. FlyBe operates numerous indirect flights every day.

Taking the train is the most popular way to travel from Liverpool to London. Taking the train is over 3 and a half hours faster than taking the bus and 2 and a half hours faster than taking a flight when travel to and from London and Liverpool's airports is taken into consideration. Taking the train is also €47 cheaper on average than taking a flight between Liverpool and London. Trains traveling from Liverpool to London depart from Liverpool's Lime Street train station and arrive at London Euston train station after at least 2:12 h of travel time. Virgin Trains operates 9 trains from London to Liverpool every day, while London Midland offers one train from Liverpool to London per day.