- Must visit
National Museum
Prague’s main museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, history, and cultural collections.
Take a flight from Sesto Fiorentino to Prague and enjoy the approximately 457 miles (737 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
There are 2 flights per day. The earliest flight runs at 06:00, the last at 22:05. October is the cheapest month to fly.
Distance 457 miles (737 km) |
Flights per day 58 |
Direct flights 2 |
First flight 6:00 AM |
Last flight 10:05 PM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Oct - Dec |
Best time to book 35 days |
Omio recommends booking the train as it is the most popular option from Sesto Fiorentino to Prague among Omio's users. If you are prioritising price take the train with prices starting from $227. For those with little time consider booking a train which can get you there in 19h 0m. The ticket price range depends on the travel mode: a train costs an average of $227, and a train costs an average of $227.
Distance: 457 miles (737 km)
Most popular Train | Driving |
|---|---|
$252 Average price Cheapest | $18 Average price (fuel + tolls) |
19h 30m Average total duration Fastest 19h 0m Onboard + 30m Additional time* | 10h 10m Average total duration (door-to-door) |
Direct Options | Direct Options |
Other travel options to Prague take longer:
Bus takes on average 36h 15m.
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s main museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, history, and cultural collections.
An important museum spread across historic Jewish sites, presenting the history and heritage of Prague’s Jewish community.
The leading venue for modern and contemporary art in Prague, with major Czech and international works in a functionalist building.
Prague’s historic central square is surrounded by landmark buildings and remains the city’s most atmospheric gathering place.
A beautiful baroque district below Prague Castle, ideal for wandering quiet lanes, gardens, and picturesque embassies and palaces.
A broad urban boulevard with deep historical importance, shopping, monuments, and easy access to major central sights.
Marinated beef sirloin served with a creamy root-vegetable sauce, bread dumplings, cranberry, and whipped cream. It is one of the most iconic Czech celebratory dishes.
Roast pork with bread dumplings and braised sauerkraut. This is a classic Czech pub meal strongly associated with traditional home cooking.
Czech-style goulash, usually beef, slowly cooked with onions and paprika and commonly served with bread dumplings. It is a staple of Prague beer halls.
Upscale riverside restaurant near Charles Bridge, known for modern Czech cuisine, polished service, and fine dining atmosphere.
Well-known Art Deco restaurant and café offering refined Czech and Central European dishes in an elegant historic interior.
Popular traditional Czech pub known for fresh Pilsner, classic dishes, and lively atmosphere in the Old Town area.
Generally cheaper than Western European capitals. Hotels in the center cost more, but food, beer, and transit are good value.
About 10% is standard in restaurants if service is good. Round up in pubs and taxis. Tip is appreciated, not mandatory. Tell the server the total before they charge your card.
Official public transport app
Václav Havel Airport Prague, Prague -> Praha hlavní nádraží, Prague
Find answers to the most common questions about traveling from Sesto Fiorentino to Prague by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

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