- Must visit
National Museum
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Flights from Saint-Louis to Prague depart on average 19 times per day, taking around 1h 22m. Cheap flight tickets for this journey start at $97 (€79) but you can travel from only $52 (€42) by bus.
There are 1 flights per day. The earliest flight runs at 06:00, the last at 21:35. The fastest flight covers the 356 miles (573 km) distance in 1h 20m. January is the cheapest month to fly.
Distance 356 miles (573 km) |
Average flight duration 1h 22m |
Cheapest ticket price $97 (€79) |
Flights per day 19 |
Direct flights 1 |
Fastest flight 1h 20m |
First flight 6:00 AM |
Last flight 9:35 PM |
Cheapest Month Jan |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Fri |
Least Busy Day Fri |
Best time to book 14 days |
Omio recommends booking the flight as it is the most popular option from Saint-Louis to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $52. For those with little time consider booking a flight which can get you there in 1h 22m. The ticket price range depends on the travel mode: a bus costs an average of $52, and a train costs an average of $100.
Distance: 356 miles (573 km)
Most popular Flight | Bus | Train | Driving |
|---|---|---|---|
$97 Average price | $59 Average price Cheapest | $179 Average price | $41 Average price (fuel + tolls) |
4h 22m Average total duration Fastest 1h 22m Onboard + 3h 0m Additional time* | 15h 43m Average total duration 15h 13m Onboard + 30m Additional time* | 11h 22m Average total duration 10h 52m Onboard + 30m Additional time* | 8h 26m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Saint-Louis to Prague:
A bus is $38 (€31) less than a flight for this route with tickets for a flight from Saint-Louis to Prague costing on average $97 (€79).
A bus is $120 (€97) less than a train for this route with tickets for a train from Saint-Louis to Prague costing on average $179 (€145).
Other travel options to Prague take longer:
Train takes on average 10h 52m.
Bus takes on average 15h 13m.
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Well-curated Jewish history museum across several historic sites. Important for understanding Prague's Jewish heritage and resilience.
Leading Czech art museum with medieval to modern works in a grand historic palace. Essential for fine art and decorative arts lovers.
Historic square at Prague's core, surrounded by Gothic and Baroque landmarks. A must for first-time visitors and classic city views.
Lively boulevard of Czech modern history, lined with shops and major buildings. Worth visiting for atmosphere and historic significance.
Romantic quarter of palaces, lanes, and church domes beneath Prague Castle. Ideal for wandering, photography, and quieter historic charm.
Slow-braised beef in a creamy root-vegetable sauce, usually served with bread dumplings. A classic Czech Sunday dish strongly linked to Bohemian home cooking.
Crisp roasted pork knuckle, often served with mustard, horseradish, and pickles. A hearty pub staple popular with Czech beer culture.
Roast pork with sauerkraut and dumplings. This iconic Czech combination is a cornerstone of traditional pub and family meals.
Traditional Czech restaurant and brewery by Prague Castle, praised for roast meats, dumplings, and polished historic interiors.
Upscale restaurant focused on Czech ingredients and game, with sophisticated service in an Art Nouveau municipal house setting.
Elegant Michelin-starred restaurant known for modern Czech tasting menus in a refined setting near the Vltava.
Moderate for Europe: transit is cheap, casual meals are reasonable, and hotels in the center can raise daily costs in peak season.
Service is often not included. Tip about 5-10% in restaurants, round up for cafes, and round up or add about 10% for taxis if service is good.
Official public transport app
Václav Havel Airport Prague -> Můstek, Prague
Find answers to the most common questions about traveling from Saint-Louis to Prague by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

Most Saint-Louis to Prague flights use the EuroAirport Basel Mulhouse Freiburg to Prague Vaclav Havel Airport airport pair. Use this guide to compare Saint-Louis and Prague airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Prague Vaclav Havel Airport is 11 km from Prague city centre. Public transport options include:
Prague Vaclav Havel Airport has practical services for this route, including Wifi, Shopping, Parking, ATM, Taxis, Accessibility, WC, Shower, Lounge, and Lost and Found Office.
Free Wi-Fi available throughout the airport. ATMs are located in Terminals 1 and 2.
Lost and found is available at the station.
Available at Prague Vaclav Havel Airport: Parking, Taxis, WC.
Accessibility facilities are available at Prague Vaclav Havel Airport: Ramps, assistance.
Here are some other resources that might have the information you need