- Must visit
The Art Institute Of Chicago
One of the premier art museums in the United States, known for its Impressionist masterpieces, modern works, and iconic collections in a landmark downtown building.
Flights from Myrtle Beach, SC to Chicago, IL depart on average 29 times per day, taking around 3h 37m. Cheap flight tickets for this journey start at $156 (€126) but you can travel from only $133 (€107) by bus.
There are 1 flights per day. The earliest flight runs at 05:00, the last at 22:10. The fastest flight covers the 738 miles (1189 km) distance in 6h 44m. December is the cheapest month to fly.
Distance 738 miles (1189 km) |
Average flight duration 3h 37m |
Cheapest ticket price $156 (€126) |
Flights per day 29 |
Direct flights 1 |
Fastest flight 6h 44m |
First flight 5:00 AM |
Last flight 10:10 PM |
Cheapest Month Dec |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jul - Sep |
Omio recommends booking the bus as it is the most popular option from Myrtle Beach, SC to Chicago, IL among Omio's users. If you are prioritising price take the flight with prices starting from $156. For those with little time consider booking a flight which can get you there in 3h 37m. The ticket price range depends on the travel mode: a flight costs an average of $156, and a bus costs an average of $133.
Distance: 738 miles (1189 km)
| Flight | Most popular Bus | Driving |
|---|---|---|
$196 Average price Cheapest | $238 Average price | $184 Average price (fuel + tolls) |
6h 37m Average total duration Fastest 3h 37m Onboard + 3h 0m Additional time* | 25h 25m Average total duration 24h 55m Onboard + 30m Additional time* | 14h 35m Average total duration (door-to-door) |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Myrtle Beach, SC to Chicago, IL:
A flight is $42 (€34) less than a bus for this route with tickets for a bus from Myrtle Beach, SC to Chicago, IL costing on average $238 (€192).
Other travel options to Chicago, IL take longer:
Bus takes on average 24h 55m.
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Chicago — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago trip today.
One of the premier art museums in the United States, known for its Impressionist masterpieces, modern works, and iconic collections in a landmark downtown building.
A world-class natural history museum famous for its dinosaur fossils, ancient cultures, and major scientific collections, including the celebrated T. rex specimen SUE.
A large interactive science museum in Hyde Park with hands-on exhibits, transportation displays, and family-friendly experiences in a grand historic building.
Chicago’s signature downtown park combines major public art, gardens, and event spaces, making it one of the city’s essential first stops for visitors.
The city’s best-known stretch of Michigan Avenue is lined with landmark buildings, shops, and hotels, and serves as a central walking route for first-time visitors.
A highly popular waterfront promenade with excellent architecture views, bridges, and easy access to boat tours. It is one of the city’s most scenic urban walks.
Chicago’s iconic thick, buttery-crust pizza baked in a deep pan with layers of cheese, toppings, and chunky tomato sauce.
An all-beef hot dog on a poppy seed bun topped with mustard, onions, relish, tomato, pickle spear, sport peppers, and celery salt.
Thin-sliced seasoned roast beef served on a long roll, often dipped in jus and topped with sweet peppers or giardiniera.
A celebrated West Loop restaurant with bold small plates, creative flavors, and a vibrant, modern atmosphere.
Chicago’s internationally renowned fine-dining destination known for highly creative tasting menus and theatrical presentation.
A classic Chicago pizzeria famous for buttery-crust deep-dish pizza and a relaxed, family-friendly atmosphere.
Moderate for a major U.S. city: casual food is reasonable, but hotels, parking, and fine dining add up fast.
Tip 18-20% at restaurants; 20%+ for great service. Bars: USD 1-2 per drink. Taxis/rideshares: 10-15%. Hotels: USD 2-5 for housekeeping; USD 1-2 per bag.
Find answers to the most common questions about traveling from Myrtle Beach, SC to Chicago, IL by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

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