- Recommended
Hilliard Art Museum
Regional museum covering Acadian, Creole, and Native history through artifacts and exhibits that explain local identity.
The best way to find a cheap bus ticket from Charlotte, NC to Lafayette, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Charlotte, NC to Lafayette, IN will cost around $191 if you buy it on the day, but the cheapest tickets can be found for only $177.
It's difficult to get from Charlotte, NC to Lafayette, IN without transferring at least 2 times.

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Buses from Charlotte, NC to Lafayette, IN run on average 6 times per day, taking around 18h 51m. Cheap bus tickets for this journey start at $82 if you book in advance.
The earliest bus runs at 03:35, the last at 21:45. The fastest bus covers the 486 miles (783 km) distance in 16h 25m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Charlotte, NC to Lafayette, IN.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:10AM | Arrival Time 10:50PM | Duration 20h40 | Departure days Thu, Fri | Cheapest price $176 |
Operator Greyhound USA | Departure Time 02:50AM | Arrival Time 06:35AM | Duration 27h45 | Departure days Mon, Tue, Fri, Sat | Cheapest price $188 |
Operator Greyhound | Departure Time 04:50PM | Arrival Time 04:10PM | Duration 23h20 | Departure days Thu | Cheapest price $189 |
Operator Barons Bus | Departure Time 05:45PM | Arrival Time 12:15PM | Duration 18h30 | Departure days Mon, Tue, Fri, Sun | Cheapest price $177 |
The table below shows live departures for Charlotte, NC to Lafayette, IN buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:45 PM Charlotte, NC | 18h30 | 12:15 PM Lafayette, IN | 2 transfers | |
| Tuesday, November 3 | |||||
![]() | 2:50 AM Charlotte, NC | 27h45 | 6:35 AM Lafayette, IN | 3 transfers | |
![]() | 2:50 AM Charlotte, NC | 27h45 | 6:35 AM Lafayette, IN | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Charlotte, NC to Lafayette, IN with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Lafayette, IN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lafayette, IN trip today.
Regional museum covering Acadian, Creole, and Native history through artifacts and exhibits that explain local identity.
University art museum with strong regional collections, rotating exhibitions, and a manageable size for a focused visit.
Folk life museum with restored historic homes, gardens, and interpreters presenting Cajun and Creole traditions.
Walkable core with historic buildings, shops, murals, and event spaces that showcase Lafayette’s urban character.
Linear park along Bayou Vermilion with walking trails, water views, and access to cultural sites and nature.
Compact downtown park and gathering place near museums, public art, and events, useful as a starting point for exploring.
A hearty Cajun rice dish with pork, liver, peppers, and spices. It is a signature South Louisiana staple tied closely to Acadiana home cooking.
A dark, rich stew made with roux, onions, peppers, and seafood or meat, usually served over rice. It reflects Cajun and Creole cooking traditions.
A peppery crawfish stew or étouffée served over rice. It is especially popular during crawfish season and is a hallmark of Lafayette area seafood cooking.
Casual local favorite for boudin, cracklins, plate lunches, and other Acadiana staples with a market-style, down-home atmosphere.
Upscale downtown restaurant serving refined Cajun and Creole dishes, local seafood, and craft cocktails in a stylish historic space.
Popular Cajun seafood spot known for boiled crawfish in season, fried seafood, and lively family-friendly dining.
Moderate for US travel. Hotels and dining are usually cheaper than major US cities, but car-based transport and limited transit can raise visitor costs.
Tip 18-20% at restaurants, about 10-15% for taxis, and round up or tip $1 at cafes for good service.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Lafayette, IN.
Find answers to the most common questions about traveling from Charlotte, NC to Lafayette, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lafayette, IN, this guide helps you travel smarter and with confidence.

Most Charlotte, NC to Lafayette, IN buses use the Charlotte, W 4th St (Greyhound Bus Station) to Lafayette, North 3rd st / North st (Colonial Bakery Garage) station pair. Use this guide to compare Charlotte, NC and Lafayette, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Charlotte, W 4th St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Charlotte, W 4th St (Greyhound Bus Station). ATMs are available at Charlotte, W 4th St (Greyhound Bus Station).
Ticket office support is available at Charlotte, W 4th St (Greyhound Bus Station).
Available at Charlotte, W 4th St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Charlotte, W 4th St (Greyhound Bus Station): The station is wheelchair accessible.
Lafayette, North 3rd st / North st (Colonial Bakery Garage) is 1 km from Lafayette city centre. Public transport options include:
Lafayette, North 3rd st / North st (Colonial Bakery Garage) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lafayette, North 3rd st / North st (Colonial Bakery Garage). ATMs are available at Lafayette, North 3rd st / North st (Colonial Bakery Garage).
Ticket office support is available at Lafayette, North 3rd st / North st (Colonial Bakery Garage).
Available at Lafayette, North 3rd st / North st (Colonial Bakery Garage): Parking, Taxis, WC.
Accessibility facilities are available at Lafayette, North 3rd st / North st (Colonial Bakery Garage): Accessible for wheelchairs.
Check bus stations information for Charlotte, NC and Lafayette, IN, including where buses depart and arrive on this route.