- Must visit
Cummer Museum of Art & Gardens
Major art museum with American and European works, a notable sculpture garden, and one of Jacksonville's top cultural stops.
Omio recommends booking the flight as it is the most popular option from Anderson, SC to Jacksonville, FL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $173 For those with little time, consider booking a flight, which has an average total journey time of 4h 54m. Average ticket prices depend on the travel mode: a bus costs an average of $173, while a flight costs an average of $858.
Distance: 293 miles (473 km)
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$173 Average price Cheapest | $858 Average price | $343 Average price | $70 Average price (fuel + tolls) |
9h 25m Average total duration 8h 55m Onboard + 30m Additional time* | 4h 54m Average total duration Fastest 2h 54m Onboard + 2h 0m Additional time* | 23h 12m Average total duration 22h 42m Onboard + 30m Additional time* | 5h 55m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Anderson, SC to Jacksonville, FL:
A bus is $171 less than a train for this route with tickets for a train from Anderson, SC to Jacksonville, FL costing on average $343.
A bus is $685 less than a flight for this route with tickets for a flight from Anderson, SC to Jacksonville, FL costing on average $858.
Other travel options to Jacksonville, FL take longer:
Bus takes on average 8h 55m.
Train takes on average 22h 42m.
Tickets start at around $173 compared to roughly $70 in fuel and tolls — a saving of about $-103.28. The journey takes 8h 55m versus 5h 55m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:55AM | Arrival Time 06:35PM | Duration 12h40 | Departure days Thu | Cheapest price $166 |
Operator FlixBus | Departure Time 03:50PM | Arrival Time 03:05AM | Duration 11h15 | Departure days Thu | Cheapest price $181 |
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Anderson, SC to Jacksonville, FL run on average 3 times per day, taking around 8h 55m. Cheap bus tickets for this journey start at $159 if you book in advance.
The earliest bus runs at 09:05, the last at 18:30. The fastest bus covers the 293 miles (473 km) distance in 8h 35m.
Distance 293 miles (473 km) |
Average bus duration 8h 55m |
Cheapest ticket price $159 |
Buses per day 3 |
Fastest bus 8h 35m |
First bus 9:05 AM |
Last bus 6:30 PM |
Cheapest Month Oct |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Jan - Mar |
Discover the best of Jacksonville, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Jacksonville, FL trip today.
Major art museum with American and European works, a notable sculpture garden, and one of Jacksonville's top cultural stops.
Regional history museum covering Northeast Florida through engaging exhibits on city growth, culture, and key local events.
Contemporary art museum in the university district, presenting rotating exhibitions and thoughtful programs by living artists.
Lively riverfront district with museums, restaurants nearby, public art, and one of Jacksonville's best skyline strolls.
Scenic promenade across the river from downtown, ideal for walks, bridge views, and sunset photos along the Southbank.
Creative historic neighborhood known for murals, local shops, nightlife, and a walkable mix of old Jacksonville character.
Mayport shrimp are local Atlantic shrimp, prized for their sweet flavor. They are a Jacksonville seafood staple, often served fried, grilled, or in baskets near the coast.
A Low Country boil with shrimp, sausage, corn, and potatoes reflects Northeast Florida’s coastal Southern cooking and is popular at casual local seafood spots.
Fresh local oysters from nearby Florida waters are served raw, baked, or chargrilled. They are a classic Jacksonville choice tied to the region’s seafood culture.
Popular casual seafood restaurant in Mayport, best known for fresh local shrimp, fried seafood platters, and a laid-back dockside feel.
Refined riverfront steakhouse known for prime steaks, seafood, and polished service in an upscale setting on the Southbank.
Established upscale seafood restaurant with an extensive wine list, elegant atmosphere, and strong reputation for fresh fish and fine dining.
Moderate for US beach cities. Hotels vary by season; meals and coffee are typical US prices, and most visitors need a car as transit is limited.
Tip 18-20% at restaurants, more for great service. Taxis usually get 10-15%. Cafes often use tip jars or screens; $1-2 is common.
Find answers to the most common questions about traveling from Anderson, SC to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.

Most Anderson, SC to Jacksonville, FL buses use the Anderson, Highway 81 S (Greyhound Bus Station) to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St station pair. Use this guide to compare Anderson, SC and Jacksonville, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Anderson, Highway 81 S (Greyhound Bus Station) is 14 km from Anderson city centre. Public transport options include:
Anderson, Highway 81 S (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi in waiting area. ATMs are available at Anderson, Highway 81 S (Greyhound Bus Station).
Ticket office support is available at Anderson, Highway 81 S (Greyhound Bus Station).
Available at Anderson, Highway 81 S (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Anderson, Highway 81 S (Greyhound Bus Station): Wheelchair accessible entrance and seating.
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 km from Jacksonville city centre. Public transport options include:
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. ATMs are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Ticket office support is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Parking, Taxis, WC.
Accessibility facilities are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Wheelchair accessible entrances.
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