- Must visit
Cummer Museum of Art & Gardens
Major art museum with American and European works, a notable sculpture garden, and one of Jacksonville's top cultural stops.
Omio recommends booking the bus as it is the most popular option from Anderson, SC to Jacksonville, FL among Omio's users. If you are prioritising price take the bus with prices starting from $165. For those with little time consider booking a flight which can get you there in 4h 8m. The ticket price range depends on the travel mode: a bus costs an average of $165, and a flight costs an average of $292.
Distance: 293 miles (473 km)
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$173 Average price Cheapest | $264 Average price | $331 Average price | $69 Average price (fuel + tolls) |
12h 28m Average total duration 11h 58m Onboard + 30m Additional time* | 29h 21m Average total duration 28h 51m Onboard + 30m Additional time* | 7h 8m Average total duration Fastest 4h 8m Onboard + 3h 0m Additional time* | 5h 55m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Anderson, SC to Jacksonville, FL:
A bus is $90 (€74) less than a train for this route with tickets for a train from Anderson, SC to Jacksonville, FL costing on average $264 (€216).
A bus is $158 (€129) less than a flight for this route with tickets for a flight from Anderson, SC to Jacksonville, FL costing on average $331 (€271).
Other travel options to Jacksonville, FL take longer:
Bus takes on average 11h 58m.
Train takes on average 28h 51m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:55AM | Arrival Time 06:35PM | Duration 12h40 | Departure days Thu | Cheapest price $165 |
Operator FlixBus | Departure Time 03:50PM | Arrival Time 03:05AM | Duration 11h15 | Departure days Thu | Cheapest price $181 |
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Anderson, SC to Jacksonville, FL run on average 3 times per day, taking around 11h 58m. Cheap bus tickets for this journey start at $165 (€135) if you book in advance.
The earliest bus runs at 09:05, the last at 18:30. The fastest bus covers the 293 miles (473 km) distance in 11h 15m.
Distance 293 miles (473 km) |
Average bus duration 11h 58m |
Cheapest ticket price $165 (€135) |
Buses per day 3 |
Fastest bus 11h 15m |
First bus 9:05 AM |
Last bus 6:30 PM |
Cheapest Month Oct |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Jan - Mar |
Discover the best of Jacksonville, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Jacksonville, FL trip today.
Major art museum with American and European works, a notable sculpture garden, and one of Jacksonville's top cultural stops.
Regional history museum covering Northeast Florida through engaging exhibits on city growth, culture, and key local events.
Contemporary art museum in the university district, presenting rotating exhibitions and thoughtful programs by living artists.
Lively riverfront district with museums, restaurants nearby, public art, and one of Jacksonville's best skyline strolls.
Scenic promenade across the river from downtown, ideal for walks, bridge views, and sunset photos along the Southbank.
Creative historic neighborhood known for murals, local shops, nightlife, and a walkable mix of old Jacksonville character.
Mayport shrimp are local Atlantic shrimp, prized for their sweet flavor. They are a Jacksonville seafood staple, often served fried, grilled, or in baskets near the coast.
A Low Country boil with shrimp, sausage, corn, and potatoes reflects Northeast Florida’s coastal Southern cooking and is popular at casual local seafood spots.
Fresh local oysters from nearby Florida waters are served raw, baked, or chargrilled. They are a classic Jacksonville choice tied to the region’s seafood culture.
Popular casual seafood restaurant in Mayport, best known for fresh local shrimp, fried seafood platters, and a laid-back dockside feel.
Refined riverfront steakhouse known for prime steaks, seafood, and polished service in an upscale setting on the Southbank.
Established upscale seafood restaurant with an extensive wine list, elegant atmosphere, and strong reputation for fresh fish and fine dining.
Moderate for US beach cities. Hotels vary by season; meals and coffee are typical US prices, and most visitors need a car as transit is limited.
Tip 18-20% at restaurants, more for great service. Taxis usually get 10-15%. Cafes often use tip jars or screens; $1-2 is common.
Find answers to the most common questions about traveling from Anderson, SC to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.

Most Anderson, SC to Jacksonville, FL buses use the Anderson, Highway 81 S (Greyhound Bus Station) to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St station pair. Use this guide to compare Anderson, SC and Jacksonville, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
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