- Must visit
Istanbul Modern
Leading contemporary art museum on the Bosphorus with strong Turkish and international exhibitions in a landmark waterfront building.
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The cheapest and fastest buses from Alexandroupoli to Istanbul
Showing times, prices and bookable tickets for Sep 18
Cheapest price on Sep 18
Kč648
Average ticket price on Sep 18
Kč648
Fastest journey on Sep 18
4 h 15 m
Average journey duration on Sep 18
4 h 27 m
Buses on Sep 18
3
Distance
259 km
Cheap tickets
The best way to find a cheap bus ticket from Alexandroupoli to Istanbul is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Alexandroupoli to Istanbul will cost around Kč648 if you buy it on the day, but the cheapest tickets can be found for only Kč648.
Fast buses
On Fri, Sep 18, we found 3 buses from Alexandroupoli to Istanbul, including 3 direct services.
On Fri, Sep 18 the direct buses cover the 259 km distance in an average of 4 h 27 m but if you time it right, some buses will get you there in just 4 h 15 m .
On Fri, Sep 18 the slowest buses will take 4 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
04:40 AM4h20Alexandroupoli9:00 AMIstanbulKč6481One-way0 transfers- 011:30 PM4h45Alexandroupoli4:15 AMIstanbulKč6481One-way0 transfers
- 01:35 PM4h15Alexandroupoli5:50 PMIstanbulKč6481One-way0 transfers
- 01:35 PM4h15Alexandroupoli5:50 PMIstanbulKč6481One-way0 transfers
- 04:40 AM4h20Alexandroupoli9:00 AMIstanbulKč6481One-way0 transfers
- 011:30 PM4h45Alexandroupoli4:15 AMIstanbulKč6481One-way0 transfers
Travel Information
Compare bus and flight for Alexandroupoli to Istanbul
Omio recommends booking the bus as it is the most popular option from Alexandroupoli to Istanbul among Omio's users. If you are prioritising price, take the bus, with an average ticket price of Kč634 For those with little time, consider booking a flight, which has an average total journey time of 4h 41m. Average ticket prices depend on the travel mode: a bus costs an average of Kč634, while a flight costs an average of Kč7510.
Distance: 160 miles (259 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
Kč634 Average price Cheapest | Kč7510 Average price | Kč1581 Average price (fuel + tolls) |
4h 45m Average total duration 4h 15m Onboard + 30m Additional time* | 4h 41m Average total duration Fastest 2h 41m Onboard + 2h 0m Additional time* | 3h 59m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Alexandroupoli to Istanbul is a bus with an average price of Kč634.
This is compared to other travel options from Alexandroupoli to Istanbul:
A bus is Kč6876 less than a flight for this route with tickets for a flight from Alexandroupoli to Istanbul costing on average Kč7510.
The fastest way to travel from Alexandroupoli to Istanbul is by flight with an average journey time of 2h 41m.
Other travel options to Istanbul take longer:
Bus takes on average 4h 15m.
It's helpful to compare your options as there are 2 ways to travel between Alexandroupoli and Istanbul including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Alexandroupoli to Istanbul among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around Kč634 compared to roughly Kč1581 in fuel and tolls — a saving of about Kč947. The journey takes 4h 15m versus 3h 59m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by ArdaTur, Infobus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Alexandroupoli to Istanbul Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator ArdaTur | Departure Time 01:40AM | Arrival Time 06:00AM | Duration 4h20 | Departure days Wed | Cheapest price Kč739 |
Operator ArdaTur | Departure Time 04:40AM | Arrival Time 09:00AM | Duration 4h20 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price Kč648 |
Operator ArdaTur | Departure Time 10:35AM | Arrival Time 02:50PM | Duration 4h15 | Departure days Wed | Cheapest price Kč739 |
Operator ArdaTur | Departure Time 11:35AM | Arrival Time 02:50PM | Duration 3h15 | Departure days Wed | Cheapest price Kč745 |
Operator ArdaTur | Departure Time 01:35PM | Arrival Time 05:50PM | Duration 4h15 | Departure days Mon, Tue, Fri, Sat | Cheapest price Kč648 |
Operator ArdaTur | Departure Time 11:30PM | Arrival Time 04:15AM | Duration 4h45 | Departure days Mon, Tue, Thu, Fri, Sun | Cheapest price Kč648 |
Live departures
Alexandroupoli to Istanbul bus times
The table below shows live departures for Alexandroupoli to Istanbul buses for today, Thursday, September 17. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 7520396 | 11:30 PM Alexandroupoli | 4h45 | 4:15 AM Istanbul | 0 transfersDirect | |
| Friday, September 18 | |||||
| 0 | 4:40 AM Alexandroupoli | 4h20 | 9:00 AM Istanbul | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Alexandroupoli to Istanbul by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Alexandroupoli to Istanbul buses with Omio?
ArdaTur as well as Infobus offer buses services from Alexandroupoli to Istanbul.
Omio is the only official third party seller for ArdaTur tickets.
Why book with Omio vs ArdaTur?
- Compare with other providers: On Omio, you can not only buy tickets for ArdaTur, but also compare tickets for the likes of Infobus to find the best option for your trip from Alexandroupoli to Istanbul.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare ArdaTur with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Alexandroupoli to Istanbul.
Journey information
Overview: Bus from Alexandroupoli to Istanbul
Greece
Turkey
Buses from Alexandroupoli to Istanbul run on average 3 times per day, taking around 4h 15m. Cheap bus tickets for this journey start at Kč518 if you book in advance.
There are 3 buses per day. The earliest bus runs at 00:30, the last at 23:30. The fastest bus covers the 160 miles (259 km) distance in 3h 15m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 160 miles (259 km) |
Average bus duration 4h 15m |
Cheapest ticket price Kč518 |
Buses per day 3 |
Direct buses 3 |
Fastest bus 3h 15m |
First bus 12:30 AM |
Last bus 11:30 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Sun |
Least Busy Day Thu |
Best time to book 28 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: ArdaTur, Infobus from Alexandroupoli to IstanbulYou can travel by bus between Alexandroupoli to Istanbul with ArdaTur, Infobus for as low as Kč518. When you search for schedules and tickets, Omio will show you the best journey
Infobus
About
Infobus is an international IT company that operates as an online service for finding and purchasing bus, train, and plane tickets, rather than being a bus company itself. Established in 2002, Infobus acts as an intermediary between passengers and various transport carriers, particularly helping smaller bus companies offer online booking services. They utilize their own "BusSystem" to manage routes and ticket sales globally. Infobus covers over 30 countries and 300 cities, offering a wide range of routes and daily departures. While amenities can vary by carrier, Infobus aims to provide affordable and convenient travel with features like online booking, 24/7 support, and prompt notifications.
Luggage & cancellation policy
Average Infobus Duration
5h 1m
Cheapest Infobus Price
Kč518
Infobus frequency
1 a day
Luggage included
One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
Additional luggage
10€ per additional bag.
Cancellation Policy
You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Transport for wheelchairs and mobility aids.
Bikes
Bikes are allowed; may require prior reservation and an additional fee.
Pets
Small pets allowed in carriers; larger pets may require a separate ticket.
ArdaTur
About
ArdaTur is a bus company based in Haskovo, Bulgaria, established in 1991. It offers extensive bus services across seven countries, including Bulgaria, Greece, Turkey, Austria, the Czech Republic, Hungary, and Germany. ArdaTur operates over 233 daily departures, primarily from major cities like Istanbul, Sofia, and Thessaloniki, providing both intercity and regional routes. The company emphasizes passenger comfort with amenities such as Wi-Fi, restrooms, individual monitors, and complimentary food and drinks on international lines. ArdaTur maintains a modern fleet of over 80 luxury buses and has its own garage and service facility to ensure vehicle reliability and safety.
Luggage & cancellation policy
Average ArdaTur Duration
3h 15m
Cheapest ArdaTur Price
Kč648
ArdaTur frequency
3 a day
Luggage included
One piece of hand luggage up to 15 kg and two pieces of checked luggage up to 35 kg each are included.
Additional luggage
Additional baggage or cargo is accepted for transport if there is free space and for a separate charge.
Cancellation Policy
Cancellation policies vary by ticket class, individual trips, or promotions, with refunds ranging from 50% to 100% depending on the time before departure, and no refunds for cancellations less than 24 hours prior.
Refund
If the trip is delayed through the fault of the carrier, 100% of the ticket value and compensation for direct costs to the place of departure will be refunded with supporting documents.
Amenities on board the bus
Wifi
Seat reservation
Seat reservations are possible when buying a ticket or at Arda Tur offices up to 24 hours before departure during weak periods and 72 hours during busy periods.
Toilets
Accessibility
Passengers with disabilities receive discounts and priority seating, and folding wheelchairs are transported free of charge with advance registration.
Bikes
Only foldable bikes are allowed.
Complete guide to Istanbul
Things to do in Istanbul
Discover the best of Istanbul — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Istanbul trip today.
- Must visit
Istanbul Archaeological Museums
Major archaeology museum complex displaying masterpieces from ancient Anatolia, Mesopotamia, and the classical world.
- Must visit
Kariye Museum
Restored church-museum famed for exceptional Byzantine mosaics and frescoes that rival the city’s most celebrated monuments.
- Must visit
Sultanahmet Square
Historic square between Hagia Sophia and the Blue Mosque, ideal for walking among Istanbul’s greatest imperial monuments.
- Must visit
İstiklal Avenue
Lively pedestrian avenue lined with historic passages, shops, consulates, and culture venues in the heart of Beyoğlu.
- Must visit
Galata Neighborhood
Historic uphill quarter around the tower with narrow lanes, old facades, and photogenic walks toward Karaköy.
Adana Kebab
Grilled minced lamb kebab from southeastern Turkey, served with vegetables and lavash. A staple in Istanbul kebab houses and a classic local favorite.
- Gluten-free
Midye Dolma
Rice pilaf, currants, pine nuts, and herbs stuffed into mussel shells. A famous Istanbul street food, especially along waterfront districts.
- Vegetarian
Baklava
Layers of thin dough with pistachios or walnuts and syrup. An Ottoman dessert strongly associated with Istanbul's historic sweet shops.
Matbah Restaurant
Historic Sultanahmet restaurant known for refined Ottoman dishes and elegant service in a classic setting near major sights.
Asmalı Cavit
Beloved meyhane in Beyoğlu serving classic meze, rakı, and seasonal seafood in a lively, traditional tavern environment.
Balıkçı Sabahattin
Established Bosphorus fish restaurant known for fresh seafood, meze, and water views. A polished choice for a classic Istanbul dinner.
Turkish lira (₺)
Moderate for major city breaks: dining and transit are reasonable, but central hotels and tourist areas cost more than many nearby Turkish destinations.
Average meal costs
- Budget
- ₺250-450 for street food or simple lokanta meal.
- Mid-range
- ₺600-1,200 per person for a restaurant meal.
- Fine dining
- ₺1,500+ per person for upscale dining.
- Coffee
- ₺90-160 for coffee or cappuccino.
Tipping culture
Restaurants: 5-10% if service not included. Cafes: round up or leave small change. Taxis: round up the fare; larger tips are optional.
FAQs: Bus from Alexandroupoli to Istanbul
Find answers to the most common questions about traveling from Alexandroupoli to Istanbul by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Istanbul, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Alexandroupoli to Istanbul can start from as little as Kč518 when you book in advance. The average bus ticket price for Alexandroupoli to Istanbul is Kč634 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Alexandroupoli to Istanbul is 3h 15m to travel the 160 miles (259 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Alexandroupoli to Istanbul leaves at 12:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Alexandroupoli to Istanbul leaves at 11:30 PM.
Yes, there are 3 direct buses a day from Alexandroupoli to Istanbul with ArdaTur, Infobus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Alexandroupoli to Istanbul, you can count on ArdaTur, Infobus for the best way to get you to Istanbul. You can also check all possible bus companies who offer a service between Alexandroupoli and Istanbul and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή), which is located around away from the city centre, and they get off the bus at Istanbul, Buyuk Otogar (Esenler), located 5 away from the city centre.
A trip to Istanbul from Alexandroupoli is worth doing but not as a day trip with a journey time of 3h 15m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Alexandroupoli to Istanbul is July.
It's helpful to compare your options as there are 2 ways to travel between Alexandroupoli and Istanbul including taking a bus and flight.
Yes, there are bathrooms on board the bus from Alexandroupoli to Istanbul for bus company ArdaTur, Infobus.
Yes, the following accessibility options are available when taking the bus from Alexandroupoli to Istanbul:
- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- ArdaTur
- Passengers with disabilities receive discounts and priority seating, and folding wheelchairs are transported free of charge with advance registration.
Some of the most interesting sights to explore in Istanbul are:
- Hagia Sophia, a historic architectural marvel that served as a church and mosque, now a museum
- Topkapi Palace, the opulent former residence of Ottoman sultans with extensive collections of artifacts
- Blue Mosque, an iconic mosque known for its stunning blue tiles and six minarets
- Basilica Cistern, an ancient underground water reservoir featuring impressive columns and atmospheric lighting
- Galata Tower, a medieval stone tower offering panoramic views of Istanbul.
The best things to do in Istanbul include:
- Grand Bazaar, one of the world's largest and oldest covered markets offering a wide range of goods
- Bosphorus Cruise, a scenic boat tour offering views of Istanbul's skyline and historic landmarks
- Spice Bazaar, a vibrant market filled with exotic spices, sweets, and local delicacies
- Turkish Bath, experience a traditional hammam for relaxation and rejuvenation
- Explore Istiklal Avenue, a bustling street known for shopping, dining, and entertainment.
Whether you can cancel your bus ticket from Alexandroupoli to Istanbul depends on the bus companies:
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- ArdaTur
- Cancellation policies vary by ticket class, individual trips, or promotions, with refunds ranging from 50% to 100% depending on the time before departure, and no refunds for cancellations less than 24 hours prior.
Yes, bikes are allowed on board the bus with bus company ArdaTur, Infobus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Alexandroupoli to Istanbul.
Yes, the following luggage options are included when booking a bus ticket from Alexandroupoli to Istanbul:
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- ArdaTur
- One piece of hand luggage up to 15 kg and two pieces of checked luggage up to 35 kg each are included.
Yes, the following additional luggage options are available when booking a bus ticket from Alexandroupoli to Istanbul:
- Infobus
- 10€ per additional bag.
- ArdaTur
- Additional baggage or cargo is accepted for transport if there is free space and for a separate charge.
Yes, you can bring your pet on the bus from Alexandroupoli to Istanbul. The following conditions apply:
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
You can reserve your seat on the bus from Alexandroupoli to Istanbul with the following bus company: ArdaTur, Infobus
Yes, there are USB plugs on board the bus from Alexandroupoli to Istanbul with the following bus company: Infobus.
Yes, there is Wifi on board the bus from Alexandroupoli to Istanbul with the following bus company: ArdaTur, Infobus.
Istanbul is outside the Schengen Area. Travelers departing from Alexandroupoli will need a valid passport and may require a visa depending on their nationality. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Alexandroupoli to Istanbul among Omio's users.
Türkiye uses the Turkish Lira (TRY) as its currency. Travelers often find cards widely accepted in major cities and tourist areas, but carrying some cash is advisable for small purchases, local markets, and rural regions where card acceptance may be limited.
In Istanbul, travelers should be cautious of pickpocketing, especially in crowded areas like public transportation and popular tourist spots. Common scams include overpriced taxi rides without a meter, unofficial tour guides offering expensive or fake services, and street vendors selling counterfeit goods. It's advisable to use official taxis or ride-hailing apps, agree on prices beforehand, and stay vigilant in busy areas to avoid these issues.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Alexandroupoli to Istanbul
Most Alexandroupoli to Istanbul buses use the Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή) to Istanbul, Büyük Otogari (Esenler) station pair. Use this guide to compare Alexandroupoli and Istanbul bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Alexandroupoli
Arrival bus stations in Istanbul
Which Alexandroupoli station do buses to Istanbul leave from?
Buses from Alexandroupoli to Istanbul leave from Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή). The station is from Alexandroupoli city centre at Vasileos Alexandrou, Alexandroupoli 681 00, Greece.
Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή)Vasileos Alexandrou, Alexandroupoli 681 00, Greece
City-centre transport
Getting to Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή) from Alexandroupoli city centre
TRUE
Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή) bus station facilities and services
Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή). ATMs are available at Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή).
Tickets and information
Ticket office support is available at Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή).
Parking, taxis and toilets
Available at Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Alexandroupoli, Vasileos Alexandrou / Dim. Karaoli (Αλεξανδρούπολη, Βασιλέως Αλεξάνδρου / Δημ. Καραολή): Station is accessible to wheelchairs.
Which Istanbul station do buses from Alexandroupoli arrive at?
Buses from Alexandroupoli to Istanbul arrive at Istanbul, Büyük Otogari (Esenler). Istanbul, Büyük Otogari (Esenler) is 3 miles (5 km) from Istanbul city centre.
Istanbul, Büyük Otogari (Esenler)Istanbul Buyuk Otogari, Esenler, Istanbul, Turkey
City-centre transport
Getting to Istanbul, Büyük Otogari (Esenler) from Istanbul city centre
Istanbul, Büyük Otogari (Esenler) is 5 km from Istanbul city centre. Public transport options include:
TrainM1a, M1b · 11m · Kč26 · every ~45 min
Bus91E · 20m · Kč26 · every ~17 min
TramT4 · 22m · Kč26 · every ~34 min
Istanbul, Büyük Otogari (Esenler) bus station facilities and services
Istanbul, Büyük Otogari (Esenler) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food and drink
Food options include: Cafeteria Terminal (in the station), Kebab Express (0.2 km), Simit Sarayı (0.3 km).
Wi-Fi and ATMs
Free Wi-Fi. ATMs are located near the main entrance and throughout the station.
Tickets and information
Ticket office support is available at Istanbul, Büyük Otogari (Esenler).
Parking, taxis and toilets
Available at Istanbul, Büyük Otogari (Esenler): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Istanbul, Büyük Otogari (Esenler): Elevators, ramps.
More options for your journey from Alexandroupoli to Istanbul
Here are some other resources that might have the information you need
Most popular buses to and from Istanbul and Alexandroupoli
Most popular bus connections to Istanbul
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