- Must visit
Greenville County Museum of Art
Major local art museum known for its Southern art collection and works by Andrew Wyeth and Jasper Johns.
Omio recommends booking the bus as it is the most popular option from Annapolis, MD to Greenville, NC among Omio's users. If you are prioritising price take the bus with prices starting from $87. For those with little time consider booking a train which can get you there in 9h 37m. The ticket price range depends on the travel mode: a bus costs an average of $87, and a train costs an average of $124.
Distance: 237 miles (382 km)
| Train | Most popular Bus | Driving |
|---|---|---|
$124 Average price | $87 Average price Cheapest | $57 Average price (fuel + tolls) |
10h 7m Average total duration Fastest 9h 37m Onboard + 30m Additional time* | 26h 35m Average total duration 26h 5m Onboard + 30m Additional time* | 5h 2m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Annapolis, MD to Greenville, NC:
A bus is $37 (€30) less than a train for this route with tickets for a train from Annapolis, MD to Greenville, NC costing on average $124 (€102).
Other travel options to Greenville, NC take longer:
Bus takes on average 26h 5m.
Tickets start at around $124 (€102) compared to roughly $57 (€47) in fuel and tolls — a saving of about $-67.07 (€-55.26). The journey takes 9h 37m versus 5h 2m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Annapolis, MD to Greenville, NC run on average 3 times per day, taking around 9h 37m. Cheap train tickets for this journey start at $124 (€102) but you can travel from only $87 (€72) by bus.
The earliest train runs at 11:57, the last at 11:57. The fastest train covers the 237 miles (382 km) distance in 9h 37m.
Distance 237 miles (382 km) |
Average train duration 9h 37m |
Cheapest ticket price $124 (€102) |
Trains per day 3 |
Fastest train 9h 37m |
First train 11:57 AM |
Last train 11:57 AM |
Cheapest Month Mar |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
Major local art museum known for its Southern art collection and works by Andrew Wyeth and Jasper Johns.
Regional history museum with family-friendly exhibits on the Upcountry of South Carolina and changing traveling shows.
Specialized museum displaying historic musical instruments from Europe, Asia, and America in a refined gallery setting.
Signature downtown park with waterfalls, gardens, lawns, and scenic walking paths at the heart of Greenville.
Greenville’s lively central street lined with shops, public art, plazas, and a polished walkable downtown atmosphere.
Popular multi-use greenway for walking and cycling, linking Greenville with riverfront and neighborhood scenery.
Slow-smoked pork, often chopped or pulled, traditionally served with the state’s signature mustard-based barbecue sauce in the Upstate.
Sliced unripe tomatoes coated and fried until crisp, a classic Southern starter popular across Greenville and the Upstate.
Creamy stone-ground grits topped with shrimp, usually with bacon or rich pan sauce, reflecting Lowcountry influence on local menus.
Well-regarded neighborhood restaurant with seasonal Southern-influenced cooking, craft cocktails, and a modern intimate setting.
A long-running downtown restaurant known for refined Southern cuisine, shrimp and grits, and a polished but approachable atmosphere.
Stylish Falls Park area restaurant known for house-made pasta, oysters, and scenic views, ideal for an upscale meal.
Prices are moderate by U.S. standards. Dining and coffee are reasonable, while upscale restaurants cost more.
Tip 18-20% at full-service restaurants. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and delivery drivers.
Find answers to the most common questions about traveling from Annapolis, MD to Greenville, NC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Greenville, NC, this guide helps you travel smarter and with confidence.

Most Annapolis, MD to Greenville, NC trains use the New Carrollton Amtrak Station to Greenville, G K Butterfield Transportation Center station pair. Use this guide to compare Annapolis, MD and Greenville, NC train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
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