- Must visit
National Museum of Civil War Medicine
Interactive museum explaining battlefield medicine, surgery, and care during the Civil War in a historic downtown building.
Take a flight from Portland, ME to Frederick, MD and enjoy the approximately 472 miles (760 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest flight runs at 05:40, the last at 12:29. August is the cheapest month to fly.
Distance 472 miles (760 km) |
First flight 5:40 AM |
Last flight 12:29 PM |
Cheapest Month Aug |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Apr - Jun |
Discover the best of Frederick, MD — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Frederick, MD trip today.
Interactive museum explaining battlefield medicine, surgery, and care during the Civil War in a historic downtown building.
Regional history museum with exhibits on Frederick County life, culture, and changing communities inside a restored historic home.
Contemporary art space in downtown Frederick presenting rotating exhibitions by regional and national artists in a modern gallery setting.
Linear downtown park and promenade with fountains, public art, bridges, and event spaces, ideal for walking day or evening.
Central historic district with preserved architecture, local shops, galleries, and easy access to many of Frederick’s main sights.
Popular downtown street lined with historic buildings, boutiques, public art, and one of the city’s best pedestrian atmospheres.
Maryland crab cakes are packed with blue crab and light seasoning. They are a regional staple near Frederick and widely served across Central Maryland.
Cream of crab soup is a rich Maryland favorite made with crab meat, cream, and seasoning. It reflects the state's strong Chesapeake seafood tradition.
Smith Island cake is Maryland's official state dessert, with many thin cake layers and frosting. It is a classic sweet treat found around Frederick.
Well-known farm brewery outside downtown with estate beer, pizza, and scenic grounds suited to relaxed afternoons.
Contemporary American restaurant known for wood-fired dishes, cocktails, and a polished but relaxed downtown atmosphere.
Casual local favorite for New York-style pizza, pasta, and Italian-American comfort food in the historic district.
Moderate for a U.S. mid-size city: hotels and dining are below major metros, but car-based transport and limited transit can raise visitor costs.
Tip 18-20% at restaurants, more for excellent service. Taxis usually 10-15%. Cafes often have tip jars; $1-2 is common.
Find answers to the most common questions about traveling from Portland, ME to Frederick, MD by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Frederick, MD, this guide helps you travel smarter and with confidence.

Most Portland, ME to Frederick, MD flights use the Portland International Jetport to Ronald Reagan National Airport airport pair. Use this guide to compare Portland, ME and Frederick, MD airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Portland International Jetport is 1 km from Portland city centre. Public transport options include:
Portland International Jetport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Lounge, Lost and Found Office, and Car Rental.
Food options include: Restaurants available include Linda Bean's Lobster Cafe and Starbucks in the terminal.
Free Wi-Fi available throughout the airport. ATMs are located near the baggage claim area.
Lost and found is available at the station.
Available at Portland International Jetport: Parking, Taxis, WC.
Available at Portland International Jetport: Car Rental.
Accessibility facilities are available at Portland International Jetport: Elevators, ramps.
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