- Must visit
Centro Botín
Major contemporary art center on Santander’s waterfront, known for international exhibitions, cultural programming, and its striking Renzo Piano design.
Flights from Orio al Serio to Santander depart on average 10 times per day, taking around 4h 15m. Cheap flight tickets for this journey start at $227 (€186) but you can travel from only $130 (€106) by bus.
The earliest flight runs at 06:05, the last at 21:55. The fastest flight covers the 681 miles (1096 km) distance in 4h 15m. April is the cheapest month to fly.
Distance 681 miles (1096 km) |
Average flight duration 4h 15m |
Cheapest ticket price $227 (€186) |
Flights per day 10 |
Fastest flight 4h 15m |
First flight 6:05 AM |
Last flight 9:55 PM |
Cheapest Month Apr |
Cheapest Day Sat |
High Season Jan - Mar |
Low Season Oct - Dec |
Omio recommends booking the bus as it is the most popular option from Orio al Serio to Santander among Omio's users. If you are prioritising price take the bus with prices starting from $130. For those with little time consider booking a flight which can get you there in 4h 15m. The ticket price range depends on the travel mode: a bus costs an average of $130, and a flight costs an average of $227.
Distance: 681 miles (1096 km)
| Flight | Most popular Bus | Driving |
|---|---|---|
$227 Average price | $130 Average price Cheapest | $278 Average price (fuel + tolls) |
7h 15m Average total duration Fastest 4h 15m Onboard + 3h 0m Additional time* | 29h 10m Average total duration 28h 40m Onboard + 30m Additional time* | 13h 50m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Orio al Serio to Santander:
A bus is $97 (€80) less than a flight for this route with tickets for a flight from Orio al Serio to Santander costing on average $227 (€186).
Other travel options to Santander take longer:
Bus takes on average 28h 40m.
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Santander — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santander trip today.
Major contemporary art center on Santander’s waterfront, known for international exhibitions, cultural programming, and its striking Renzo Piano design.
Important archaeological museum presenting prehistoric cave culture, Roman material, and key finds from across Cantabria.
Leading maritime museum covering Cantabrian Sea ecology, fishing, naval history, and aquariums; a strong family-friendly cultural stop.
Scenic headland combining gardens, sea views, beaches, and the palace grounds; ideal for walking and one of the city’s top experiences.
Santander’s best-known beach area, famous for its elegant promenade, broad sands, and lively atmosphere in good weather.
Grand waterfront promenade lined with historic buildings, sculptures, and access to the bay; essential for a first walk through Santander.
Lightly battered and fried squid rings, one of Santander’s most iconic tapas, especially popular for aperitif time by the bay.
High-quality Cantabrian anchovies, usually served in olive oil on bread or as a tapa; a flagship product of the region.
White tuna from the Cantabrian Sea, prized for its delicate texture and often served grilled, stewed, or preserved in olive oil.
Michelin-starred restaurant known for contemporary tasting menus rooted in Cantabrian products, with polished service and elegant ambiance.
Well-known Santander restaurant and tapas bar, famous for refined Cantabrian cuisine, seafood, and a lively central atmosphere.
Historic and established dining room serving classic Cantabrian dishes in a traditional setting with strong local character.
Moderate by Spanish standards: tapas and set lunches are affordable, while waterfront dining and summer stays cost more.
Tipping is modest. Round up or leave 5-10% in restaurants for good service. Small change in cafes is enough. Taxis are usually rounded up, and hotel tips are appreciated but not expected.
Official public transport app
Santander Airport -> Santander Bus Station
Find answers to the most common questions about traveling from Orio al Serio to Santander by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Santander, this guide helps you travel smarter and with confidence.

Most Orio al Serio to Santander flights use the Milan Malpensa Airport to Santander Airport airport pair. Use this guide to compare Orio al Serio and Santander airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Santander Airport is 4 km from Santander city centre. Public transport options include:
Santander Airport has practical services for this route, including Wifi, Shopping, Parking, ATM, Taxis, Accessibility, WC, Lounge, and Lost and Found Office.
Free Wi-Fi available throughout the airport. ATMs are located in the terminal.
Lost and found is available at the station.
Available at Santander Airport: Parking, Taxis, WC.
Accessibility facilities are available at Santander Airport: Elevators, ramps.
Here are some other resources that might have the information you need