Journey information
Overview: La Serena to Santiago flight
Flights from La Serena to Santiago depart on average 7 times per day, taking around 1h 0m. Cheap flight tickets for this journey start at $34 (€27) but you can travel from only $12 (€10) by bus.
There are 7 flights per day. The earliest flight runs at 04:31, the last at 22:25. The fastest flight covers the 247 miles (399 km) distance in 54m. June is the cheapest month to fly.
Distance 247 miles (399 km) |
Average flight duration 1h 0m |
Cheapest ticket price $34 (€27) |
Flights per day 7 |
Direct flights 7 |
Fastest flight 54m |
Cheapest month June |
First flight 04:31 |
Last flight 22:25 |
The cheapest and fastest flights from La Serena to Santiago
Cheapest price
$58
Average price
$96
Fastest journey
54 m
Average duration
57 m
Flights per day
4
Distance
399 km
The best way to find a cheap flight ticket from La Serena to Santiago is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from La Serena to Santiago will cost around $96 if you buy it on the day, but the cheapest tickets can be found for only $58.
Of the 4 flights that leave La Serena for Santiago onMon, Mar 02, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Mar 02 the direct flights cover the 399 km distance in an average of 57 m but if you time it right, some flights will get you there in just 54 m .
On Mon, Mar 02 the longest flights will take 59 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Travel Information
Compare bus and flight for La Serena to Santiago
Omio recommends booking the bus as it is the most popular option from La Serena to Santiago among Omio's users. If you are prioritising price take the bus with prices starting from $12. For those with little time consider booking a flight which can get you there in 1h 0m. The ticket price range depends on the travel mode: a bus costs an average of $12, and a flight costs an average of $34.
Distance: 247 miles (399 km)
Compare flight with
| Flight | Most popular Bus |
|---|---|
$83 Average price | $21 Average price Cheapest |
4h 0m Average total duration Fastest 1h 0m Onboard + 3h 0m Additional time* | 6h 25m Average total duration 5h 55m Onboard + 30m Additional time* |
![]() Most popular airline | ![]() Most popular bus company |
Direct Options | Direct Options |
Live departures
La Serena to Santiago flight times
The table below shows live departures for La Serena to Santiago flights for tomorrow, Monday, March 2. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:38 PM La Serena | 0h59 | 1:37 PM Santiago | 0 transfersDirect | |
![]() | 12:45 PM La Serena | 0h59 | 1:44 PM Santiago | 0 transfersDirect | |
![]() | 3:37 PM La Serena | 0h54 | 4:31 PM Santiago | 0 transfersDirect | |
![]() | 3:40 PM La Serena | 0h56 | 4:36 PM Santiago | 0 transfersDirect | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets La Serena to Santiago by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 02
Mar 03
Mar 04
Mar 05
Mar 06
Mar 07
Mar 08
Why should you book La Serena to Santiago flights with Omio?
Why book with Omio vs LATAM Airlines?
- Compare with other providers: On Omio, you can not only buy tickets for LATAM Airlines, but also compare tickets for the likes of B & H Airlines or Sky Airline to find the best option for your trip from La Serena to Santiago.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare LATAM Airlines with all available travel options, which are bus and flight to ensure you get the best deal for traveling from La Serena to Santiago.
Why book with Omio over Kayak, Edreams or Skyscanner?
- Compare with other providers: On Omio, you can also compare tickets for the likes of B & H Airlines or Sky Airline to find the best option for your trip from La Serena to Santiago.
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from La Serena to Santiago.
Airlines: LATAM Airlines, B & H Airlines, Sky Airline from La Serena to SantiagoFind the best flights between La Serena to Santiago with Omio's travel partners LATAM Airlines, B & H Airlines, Sky Airline from $12 (€10). We can find you the best deals, schedules and tickets when comparing and booking the best trip.
LATAM Airlines
Sky Airline
B & H Airlines
FAQs: La Serena to Santiago Flight
Find answers to the most common questions about traveling from La Serena to Santiago by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Santiago, this guide helps you travel smarter and with confidence.

- Fiesta de la Vendimia, a vibrant wine harvest festival celebrating Chile's winemaking heritage with tastings, music, and cultural events
- Santiago a Mil, an international theater festival featuring performances from around the world in various venues across the city
- Fiestas Patrias, Chile's national celebrations with parades, traditional food, and folk music honoring the country's independence.
- Fiestas Patrias, vibrant national celebrations with parades, traditional music, and delicious food
- New Year’s Day, lively festivities and fireworks to welcome the new year in a warm climate
- Easter, a time for cultural and religious observances with beautiful processions.
popular airports
Popular airports from La Serena to Santiago
- Free Wi-Fi available throughout the airport.
- Shops include duty-free and local Chilean products, located in both terminals.
- Parking available in several lots, approximately 1.7€ (CLP 1,500) per hour.
- Restaurants available in both domestic and intertiol terminals; options include fast food and Chilean cuisine.
- Available outside the terminal.
- Elevators, ramps
- Available throughout the airport.
- Hotels nearby include Holiday Inn Santiago Airport, within walking distance.
- Showers available in VIP lounges; access may require a lounge pass or fee.
- Several lounges available, including LATAM and American Airlines lounges.
- Lost and Found located in the arrivals area.
- Car rental services available from major companies like Hertz and Avis.
- Bus Centropuerto, Pajaritos Station, 19 km
More options for your journey from La Serena to Santiago
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