- Must visit
Portland Art Museum
World-class collections spanning Native American, Asian, and Northwest art. A cornerstone cultural stop in the South Park Blocks.
Omio recommends booking the flight as it is the most popular option from Medford, OR to Portland, OR among Omio's users. If you are prioritising price, take the flight, with an average ticket price of $280 For those with little time, consider booking a flight, which has an average total journey time of 3h 33m. Average ticket prices depend on the travel mode: a flight costs an average of $280, while a flight costs an average of $280.
Distance: 221 miles (356 km)
Most popular Flight | Driving |
|---|---|
$280 Average price Cheapest | $56 Average price (fuel + tolls) |
3h 33m Average total duration Fastest 1h 33m Onboard + 2h 0m Additional time* | 4h 12m Average total duration (door-to-door) |
![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options |
This is compared to other travel options from Medford, OR to Portland, OR:
A bus is $232 less than a flight for this route with tickets for a flight from Medford, OR to Portland, OR costing on average $280.
Other travel options to Portland, OR take longer:
Bus takes on average 5h 25m.
Tickets start at around $48 compared to roughly $56 in fuel and tolls — a saving of about $8. The journey takes 5h 25m versus 4h 12m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Greyhound.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Compare flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Medford, OR to Portland, OR run on average 1 times per day, taking around 5h 25m. Cheap bus tickets for this journey start at $44 if you book in advance.
There are 1 buses per day. The earliest bus runs at 02:00, the last at 16:20. The fastest bus covers the 221 miles (356 km) distance in 5h 25m.
Distance 221 miles (356 km) |
Average bus duration 5h 25m |
Cheapest ticket price $44 |
Buses per day 1 |
Direct buses 1 |
Fastest bus 5h 25m |
First bus 2:00 AM |
Last bus 4:20 PM |
Cheapest Month Oct |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Discover the best of Portland, OR — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Portland, OR trip today.
World-class collections spanning Native American, Asian, and Northwest art. A cornerstone cultural stop in the South Park Blocks.
Hands-on museum famed for the USS Blueback submarine, science labs, and family-friendly exhibits on technology and nature.
Eclectic museum of movie props, oddities, and outsider collections in Northwest Portland. Fun, quirky, and uniquely local.
A 165-acre woodland park with serene paths, a rose garden, and Japanese Garden access. One of Portland's signature green spaces.
Beloved downtown square known as Portland's living room. Hosts events, people-watching, and easy access to major central sights.
Large urban forest with miles of trails for hiking and running. A local favorite for quick immersion in nature near downtown.
A toasted bread ring with a malty crust and chewy center. Portland shops helped make the city's bagel scene a modern local obsession.
Traditional regional chowder from the Pacific Northwest, usually with local clams, cream, potatoes, and herbs. A staple on many Portland seafood menus.
Fresh oysters from the Oregon coast, prized for their briny, clean flavor. Portland is a major city showcase for the state's shellfish culture.
Acclaimed bagel shop serving naturally leavened bagels with classic toppings in a casual neighborhood space.
Pioneering specialty coffee roaster with expertly brewed coffee and a minimalist café atmosphere loved by locals.
Iconic Portland brewery and pub pouring house beers with hearty pub fare in a lively, long-running local setting.
Moderate for U.S. city travel: hotels and dining are mid-priced, transit is reasonable, and budget food is easy to find.
Tip 18-20% at restaurants, more for great service. Taxis: 10-15%. Cafes: round up or tip $1-2 for drinks.
Find answers to the most common questions about traveling from Medford, OR to Portland, OR by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Portland, OR, this guide helps you travel smarter and with confidence.

Most Medford, OR to Portland, OR buses use the Medford, Rogue Valley International-Medford Airport to Portland, NW Station Way (Station Place Parking Garage) station pair. Use this guide to compare Medford, OR and Portland, OR bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Medford, Rogue Valley International-Medford Airport is 4 km from Medford city centre. Public transport options include:
Medford, Rogue Valley International-Medford Airport has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Medford, Rogue Valley International-Medford Airport. ATMs are available at Medford, Rogue Valley International-Medford Airport.
Ticket office support is available at Medford, Rogue Valley International-Medford Airport.
Available at Medford, Rogue Valley International-Medford Airport: Parking, Taxis, WC.
Accessibility facilities are available at Medford, Rogue Valley International-Medford Airport: Wheelchair accessible routes available.
Portland, NW Station Way (Station Place Parking Garage) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Portland, NW Station Way (Station Place Parking Garage). ATMs are available at Portland, NW Station Way (Station Place Parking Garage).
Ticket office support is available at Portland, NW Station Way (Station Place Parking Garage).
Available at Portland, NW Station Way (Station Place Parking Garage): Parking, Taxis, WC.
Accessibility facilities are available at Portland, NW Station Way (Station Place Parking Garage): Ramp access available.
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