Travel Information
Compare bus and flight for Irvine, CA to Palo Alto, CA
Omio recommends booking the flight as it is the most popular option from Irvine, CA to Palo Alto, CA among Omio's users. If you are prioritising price take the bus with prices starting from $108. For those with little time consider booking a flight which can get you there in 6h 2m. The ticket price range depends on the travel mode: a bus costs an average of $108, and a flight costs an average of $357.
Distance: 356 miles (573 km)
Compare bus with
| Bus | Most popular Flight | Driving |
|---|---|---|
$108 Average price Cheapest | $357 Average price | $82 Average price (fuel + tolls) |
15h 41m Average total duration 15h 11m Onboard + 30m Additional time* | 9h 2m Average total duration Fastest 6h 2m Onboard + 3h 0m Additional time* | 6h 21m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Irvine, CA to Palo Alto, CA:
A bus is $249 (€201) less than a flight for this route with tickets for a flight from Irvine, CA to Palo Alto, CA costing on average $357 (€287).
Other travel options to Palo Alto, CA take longer:
Bus takes on average 15h 11m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Irvine, CA to Palo Alto, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Amtrak | Departure Time 06:55AM | Arrival Time 10:06PM | Duration 15h11 | Departure days Thu | Cheapest price $108 |
Compare prices and tickets Irvine, CA to Palo Alto, CA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Irvine, CA to Palo Alto, CA
Buses from Irvine, CA to Palo Alto, CA run on average 11 times per day, taking around 15h 11m. Cheap bus tickets for this journey start at $108 (€87) if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:05, the last at 23:10. The fastest bus covers the 356 miles (573 km) distance in 15h 11m.
Distance 356 miles (573 km) |
Average bus duration 15h 11m |
Cheapest ticket price $108 (€87) |
Buses per day 11 |
Direct buses 1 |
Fastest bus 15h 11m |
First bus 12:05 AM |
Last bus 11:10 PM |
Cheapest Month Oct |
Cheapest Day Fri |
High Season Oct - Dec |
Low Season Apr - Jun |
FAQs: Bus from Irvine, CA to Palo Alto, CA
Find answers to the most common questions about traveling from Irvine, CA to Palo Alto, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Palo Alto, CA, this guide helps you travel smarter and with confidence.

- Stanford University, a prestigious educational institution known for its beautiful campus and iconic Hoover Tower
- Palo Alto Baylands Nature Preserve, a vast marshland offering trails and opportunities for birdwatching
- Cantor Arts Center, an art museum featuring an extensive collection of sculptures and diverse exhibits
- Elizabeth F. Gamble Garden, a historic estate with beautifully maintained gardens open to the public
- Computer History Museum, a museum dedicated to preserving and presenting the history of computing and technology.
- Stanford Shopping Center, indulge in high-end shopping and dining at this open-air mall
- Rinconada Park, enjoy a relaxing day with picnic areas, playgrounds, and a swimming pool
- Palo Alto Art Center, explore contemporary art exhibitions and participate in community art programs
- Foothills Park, hike through scenic trails and enjoy panoramic views of the Bay Area
- Junior Museum & Zoo, a family-friendly destination with interactive science exhibits and live animal displays.
Most popular bus connections from Irvine, CA
More options for your journey from Irvine, CA to Palo Alto, CA
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